Results 71 to 80 of about 21,463 (243)

Myofibril and mitochondria morphogenesis are coordinated by a mechanical feedback mechanism in muscle

open access: yesNature Communications, 2021
Mitochondria produce high amounts of ATP to power myosin motors and sustained muscle contraction. Here, the authors show that during development, muscles coordinate the morphogenesis of their myofibrils directly with their mitochondria to optimize both ...
Jerome Avellaneda   +6 more
doaj   +1 more source

Integrating Transcriptomic and Proteome Analysis to Understand Muscle Qualities and Related Regulatory Factors of Holstein Beef Under Transportation Stress [PDF]

open access: yesFood Sci Nutr
In Holstein steers subjected to 15 h of long‐distance transportation, beef exhibited marked differences in meat quality, myofibrillar structure, and flavor components compared with cattle slaughtered without prior transport. These differences included significantly increased shear force, water loss rate, and drip loss, shortened sarcomere length, and ...
Lei Z   +5 more
europepmc   +2 more sources

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li   +12 more
wiley   +1 more source

ULTRASTRUCTURAL FEATURES OF CARDIOMYOCYTE CONTRACTILE APPARATUS IN RAT OFFSPRING HEARTS FOLLOWING MATERNAL CHRONIC ALCOHOL INTOXICATION

open access: yesПроблеми екології та медицини
Background. The mechanisms underlying the development of the heart contractile apparatus and the distribution of myofibrils in cardiomyocytes following intrauterine ethanol intoxication continue to be a topic of significant debate.
I.V. Tverdokhlib, D.G. Marchenko
doaj   +1 more source

Rheological parameters as predictors of protein functionality:A model study using myofibrils of different fibre-type composition

open access: yes, 1995
The rheology of myofibrils from a typical red muscle, m. masseter, and a typical white muscle, m. cutaneus trunci, has been studied at different pH values and salt and myofibrillar-protein concentrations.The storage modulus G' and the phase angle δ were ...
Martinsen, Berit   +5 more
core   +1 more source

Dapagliflozin alleviates high‐fat‐induced obesity cardiomyopathy by inhibiting ferroptosis

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 1358-1373, April 2025.
Abstract Aim: Dapagliflozin (Dapa) is a novel hypoglycaemic agent with multiple cardiovascular protective effects, and it is widely used in treatment of heart failure patients, but whether it can improve obese phenotype of heart failure and its mechanism is still unclear.
Di Chen   +7 more
wiley   +1 more source

Kinetic mechanism of myofibril ATPase

open access: yesBiophysical Journal, 1994
The kinetic mechanism of myofibril ATPase was investigated using psoas and mixed back muscle over a range of ionic strengths. Myofibrils were labeled with pyrene iodoacetamide to measure the rate constants for the binding of ATP and formation of the weakly attached state.
Ma, Y.Z., Taylor, E.W.
openaire   +2 more sources

Human biomarker navigator

open access: yesiMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li   +29 more
wiley   +1 more source

Polarization-resolved microscopy reveals a muscle myosin motor-independent mechanism of molecular actin ordering during sarcomere maturation.

open access: yesPLoS Biology, 2018
Sarcomeres are stereotyped force-producing mini-machines of striated muscles. Each sarcomere contains a pseudocrystalline order of bipolar actin and myosin filaments, which are linked by titin filaments.
Olivier Loison   +9 more
doaj   +1 more source

Unconventional myosins muscle into myofibrils [PDF]

open access: yesJournal of Biological Chemistry, 2019
"Myosin" is famous as a component of muscle fibrils, but the majority of myosin family members act elsewhere with roles unrelated to muscle contraction. The biological functions of a relatively new family of these unconventional myosins, myosins 18A and 18B, are poorly understood. New research from Horsthemke et al.
openaire   +3 more sources

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