Results 61 to 70 of about 32,565 (245)

Partitioning of IGFBP-5 actions in myogenesis: IGF-independent anti-apoptotic function

, 2004
Igfbp5 is upregulated during the differentiation of several key cell lineages and in some tumours; the function of IGFBP-5 in these physiological and pathological situations is unknown.
Holding, C., Pell, J.M., González, I., Laura J. Cobb, Dervis A. M. Salih, Jennifer M. Pell, Gyanendra Tripathi, Lovett, F., Fiona Lovett, Cobb, L.J., Cathy Holding, Emma J. Carter, Ivelisse Gonzalez, Salih, D.A., Carter, E.J., Tripathi, G.   +15 more
core   +1 more source

Metabolic reprogramming promotes myogenesis during aging [PDF]

, 2019
Sarcopenia is the age-related progressive loss of skeletal muscle mass and strength finally leading to poor physical performance. Impaired myogenesis contributes to the pathogenesis of sarcopenia, while mitochondrial dysfunctions are thought to play a ...
De Angelis L, Bonato A., Mirabilii S., Costelli, P., Tafuri A., Belli R., Tafuri A, Ricciardi M. R., Mirabilii S, Ferraro E., De Angelis L., Caruso M., Molfino A, Leigheb M., BELLI, ROBERTA, Caruso M, Molfino A., Muscaritoli M., Costelli P., Muscaritoli M, Costelli P, Ricciardi MR   +21 more
core   +1 more source

Recapitulating human myogenesis ex vivo using human pluripotent stem cells [PDF]

, 2022
Human pluripotent stem cells (hPSCs) provide a human model for developmental myogenesis, disease modeling and development of therapeutics. Differentiation of hPSCs into muscle stem cells has the potential to provide a cell-based therapy for many skeletal
Chien, Peggie, Pyle, April D, Xi, Haibin
core   +1 more source

Dynamic Self‐Clickable Decellularized Matrix Hydrogels for Regulating Vascularity and Enhancing Muscle Regeneration

Advanced Science, EarlyView.
Dynamic decellularized hydrogels are prepared using bovine decellularized small intestine submucosa (SIS) norbornene (dSIS‐NB). Bovine dSIS contained significant amounts of disulfide‐rich fibrillin‐I, enabling ‘self‐clickable’ thiol‐norbornene gelation and spatiotemporal tuning of hydrogel physicochemical properties.
Van Thuy Duong, Tuba Marjan, Ngoc Ha Luong, Taimoor H. Qazi, Chien‐Chi Lin   +4 more
wiley   +1 more source

Table_1_Inhibition of Postn Rescues Myogenesis Defects in Myotonic Dystrophy Type 1 Myoblast Model.DOCX

, 2021
Myotonic dystrophy type 1 (DM1) is an inherited neuromuscular disease caused by expanded CTG repeats in the 3′ untranslated region (3′UTR) of the DMPK gene.
Chao Bi (437614), Zhongxian Liu (6425717), Ao Wang (1688005), Xiaopeng Shen (4006724), Jingyi Zhang (741111), Chunguang Wang (115065), Yang Lei (136316), Guoping Zhu (386041), Feng Xu (89016), Meng Li (79487)   +9 more
core   +2 more sources

The first embryonic landscape of G-quadruplexes related to myogenesis

BMC Biology
Background DNA G-quadruplexes (G4s) represent a distinctive class of non-canonical DNA secondary structures. Despite their recognition as potential therapeutic targets in some cancers, the developmental role of G4 structures remains enigmatic.
Lijin Guo, Weiling Huang, Qi Wen, Siyu Zhang, Farhad Bordbar, Zhengzhong Xiao, Qinghua Nie   +6 more
doaj   +1 more source

Dynamic transcriptomic landscape of myogenesis in Muscovy ducks (Cairina moschata): integrative analysis of hub genes post-hatching [PDF]

Animal Bioscience
Objective Post-hatching myogenesis is a critical determinant of meat yield and quality, with potential regulatory roles of specific genes remaining underexplored in Muscovy ducks (Cairina moschata).
Xiaofeng Li, Kewei Fan, Bing Yang
doaj   +1 more source

Mechanosensitive Piezo1/Osteocalcin/Irisin Axis Protects Against Disuse‐Induced Muscle Atrophy

Advanced Science, EarlyView.
Mechanical unloading suppresses bone Piezo1 expression, which reduces circulating undercarboxylated osteocalcin (unOCN). unOCN reduction subsequently exacerbates IMM‐induced Fndc5/Irisin decrease and drives severe muscle atrophy. Bone Piezo1 activation or exogenous osteocalcin/Irisin ameliorate muscle atrophy, while muscle‐specific Gprc6a or Fndc5 ...
Zhaolu Wang, Xiuying Jiang, Xi Sun, Hao Chen, Jianjun Jin, Xin'e Shi   +5 more
wiley   +1 more source

Adipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity

Advanced Science, EarlyView.
Myoglobin, known as a muscle oxygen‐carrying protein, is shown to play a key role in fat cells that burn energy. Loss of myoglobin reduces the body's ability to generate heat and increases obesity risk, while restoring it improves metabolism. The study identifies myoglobin as a regulator of fat burning and a potential target to enhance energy ...
Christian Strehlau, Helen Broghammer, Claudia Gebhardt, Anne Hoffmann, Tobias Hagemann, Şeyma Midilli, Rachel S. Zimmer, Kristin Schubert, Vasiliki Karagiannakou, Anastasia Georgiadi, Mario Ost, Martin Krüger, Lisa Roth, Kerstin Krause, Nora Klöting, Maria Keller, Martin Wabitsch, Rima Nuwayhid, Roland H. Stimson, Michael Stumvoll, Matthias Blüher, Juliane Weiner, John T. Heiker   +22 more
wiley   +1 more source

Secretome Analysis of Skeletal Myogenesis Using SILAC and Shotgun Proteomics [PDF]

, 2011
Myogenesis, the formation of skeletal muscle, is a multistep event that commences with myoblast proliferation, followed by cell-cycle arrest, and finally the formation of multinucleated myotubes via fusion of mononucleated myoblasts.
C. Y. X'avia Chan, K. W. Michael Siu, John C. McDermott   +2 more
core   +1 more source