Results 241 to 250 of about 41,288 (271)
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Control of Myogenic Differentiation by Cellular Oncogenes
Molecular Neurobiology, 1988The establishment of a differentiated phenotype in skeletal muscle cells requires withdrawal from the cell cycle and termination of DNA synthesis. Myogenesis can be inhibited by serum components, purified mitogens, and transforming growth factors, but the intracellular signaling pathways utilized by these molecules are unknown.
M D, Schneider, E N, Olson
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The Role of the IGFs in Myogenic Differentiation
1991Of the three families of growth factors/hormones (the FGFs, TGF-betas, and IGFs) that have major effects on the differentiation of skeletal muscle cells, only the IGFs stimulate the process; indeed, the IGFs are the only well-defined agents thus far shown to stimulate myogenesis.
K A, Magri, D Z, Ewton, J R, Florini
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Hormones, Growth Factors, and Myogenic Differentiation
Annual Review of Physiology, 1991Three families of growth factors/hormones have major effects on the differentiation of skeletal muscle cells. Two (FGF and TGF-beta) are potent inhibitors, and the third (IGF) exhibits a biphasic stimulatory action (but is not inhibitory even at high concentrations).
J R, Florini, D Z, Ewton, K A, Magri
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Involvement of Hexose transport in myogenic differentiation
Journal of Cellular Physiology, 1990AbstractA high (HAHT) and a low (LAHT) affinity hexose transport system are present in undifferentiated rat L6 myoblasts; however, only the latter can be detected in multinucleated myotubes. This suggests that HAHT is either down‐regulated or modified as a result of myogenesis.
P A, Kudo, T C, Lo
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Effects of growth factors on myogenic differentiation
American Journal of Physiology-Cell Physiology, 1989It has now been well established that the terminal differentiation of muscle cells in culture is subject to control by hormones and growth factors in the incubation medium. Thus far the most potent and most extensively studied agents are fibroblast growth factor (FGF), the insulinlike growth factors (IGFs), and transforming growth factor-beta (TGF ...
J R, Florini, K A, Magri
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Re-organization of nucleolar architecture in myogenic differentiation
Journal of Cell Science, 2023ABSTRACT Myogenesis, the process of muscle differentiation, requires an extensive remodeling of the cellular transcriptome and proteome. Whereas the transcriptional program underpinning myogenesis is well characterized, the required adaptation in protein synthesis is incompletely understood.
Tetsuaki Miyake, John C. McDermott
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Overexpression of nPKC ?? is permissive for myogenic differentiation
Journal of Cellular Biochemistry, 2000Although protein kinase C (PKC) has been shown to participate in skeletal myogenic differentiation, the functions of individual isoforms of PKC in myogenesis have not been completely elucidated. These studies focused on the role of nPKC θ, an isoform of the PKC family whose expression has been shown to be regulated by commitment to the myogenic lineage,
Kathryn Miles, Michael Wagner
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A role for PKCε during C2C12 myogenic differentiation
Cellular Signalling, 2010In a previous report we have demonstrated that PLCgamma1 is involved in the differentiation process of C2C12 myoblasts, induced by insulin administration. In order to identify the downstream targets of PLCgamma1-dependent signalling, we have analyzed the expression of DAG-dependent PKC isoforms during muscle differentiation. We show that during myotube
GABOARDI, GIAN CARLO +8 more
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Myogenic Differentiation by Human Processed Lipoaspirate Cells
Plastic and Reconstructive Surgery, 2002The use of undifferentiated cells for cell-based tissue engineering and regeneration strategies represents a promising approach for skeletal muscle repair. For such strategies to succeed, a readily available source of myogenic precursor cells must be identified. We have previously shown that cells isolated from raw human lipoaspirates, called processed
Hiroshi, Mizuno +5 more
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Cell cycle exit upon myogenic differentiation
Current Opinion in Genetics & Development, 1997Myogenic precursor cells withdraw irreversibly from the cell cycle as they differentiate into mature myotubes. Cell cycle exit occurs early during the differentiation program and is required for normal expression of the contractile phenotype. Differentiated myocytes also display a decreased propensity to undergo apoptotic cell death.
K, Walsh, H, Perlman
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