Results 201 to 210 of about 281,418 (301)

6‐Shogaol Attenuates Doxorubicin‐Induced Cardiac and Skeletal Muscle Atrophy by Inhibiting E3 Ubiquitin Ligases and Necroptosis

Phytotherapy Research, EarlyView.
Doxorubicin induces cardiac and skeletal muscle atrophy by upregulating E3 ubiquitin ligases, inhibiting myogenic regulatory factors, and activating necroptosis. Cardiac atrophy can further exacerbate cardiotoxicity. 6‐Shogaol negatively regulates these processes and attenuates doxorubicin‐induced cardiac and skeletal muscle atrophy.
Xipeng Sun, Yaxian Wang, Quanjun Yang, Bo Xin, Jinlu Huang, Cheng Guo   +5 more
wiley   +1 more source

Myosin XI-1 mediates salt tolerance through a Na+ transport pathway in Arabidopsis. [PDF]

Plant Cell Physiol
Liu H, Tominaga M.
europepmc   +1 more source

The Epistemic Generativity of Using a Model of a Big Idea

Science Education, EarlyView.
ABSTRACT Science instruction should involve learners in generating and warranting ideas, what we call epistemic generation. In modeling instruction, epistemic generation should be achieved by coordinating a model structure with the experienced world in reciprocal directions denoted as developing models and using models. In the former, a model structure
Jonathan T. Shemwell, Daniel K. Capps
wiley   +1 more source

Role of Hearing Loss Genes in the Sensory Epithelia Associated With Meniere Disease

Sensory Neuroscience, EarlyView.
ABSTRACT Meniere disease (MD) is an inner ear disorder characterized by episodic vertigo, tinnitus, fluctuating sensorineural hearing loss (SNHL), and aural fullness. Its hallmark pathological feature is endolymphatic hydrops. MD shows significant familial clustering in European and East Asian populations, supporting a strong genetic component in ...
Jose A. Lopez‐Escamez, Qiuyue Mao, Patricia Perez‐Carpena   +2 more
wiley   +1 more source

Lipid droplets are rigid and physically suppress phagocytosis, unless cell compression or stretching activates actomyosin. [PDF]

Mol Biol Cell
Tobin MP, Ivanovska IL, Phan SH, Bai T, Deans J, Nader GPF, Discher DE.   +6 more
europepmc   +1 more source

Unilateral mastication‐induced memory deficits linked to disrupted hippocampal cholesterol metabolism in rats

VIEW, EarlyView.
Unilateral mastication, a common oral habit, induces cognitive decline in rats by disrupting hippocampal cholesterol metabolism. It triggers astrocyte hyperplasia, enhances cholesterol synthesis, impairs transport/degradation, and reduces 24‐hydroxycholesterol (24‐OHC), ultimately damaging synaptic function.
Xiaoting Zhai, Yifan Hu, Rongchen Xu, Xinyu Xu, Bowen Ma, Dongzong Huang, Hongchen Liu, Hongbo Li, Yuan Hu, Hua Jiang   +9 more
wiley   +1 more source

Glassy adhesion dynamics govern transitions between sub-diffusive and super-diffusive cancer cell migration on viscoelastic substrates. [PDF]

Nat Commun
Sharma V, Adebowale K, Gong Z, Chaudhuri O, Shenoy VB.   +4 more
europepmc   +1 more source

Revealing the Diverse Allergenic Protein Repertoire of Six Widely Consumed Crab Species: A Species‐Specific Allergen in King Crab

Allergy, EarlyView.
This study comprehended the allergen profiles of six edible crab species using proteomic and transcriptomic analyses and identified 11 putative allergens. King crab has a distinct protein and allergen profile, with the discovery of malate dehydrogenase as a novel king crab‐specific allergen registered as Para c 11.
Shanshan Li, Jingyuan Bian, Qing Xiong, Brian Shing‐Hei Wong, Stephen Kwok‐Wing Tsui, Kin‐Ming Kwan, Nicki Yat‐Hin Leung, Ting‐Fan Leung, Patrick S. C. Leung, Ka‐Hou Chu, Xiaojun Xiao, Christine Yee‐Yan Wai   +11 more
wiley   +1 more source