Myosins XI-K, XI-1, and XI-2 are required for development of pavement cells, trichomes, and stigmatic papillae in
BMC Plant Biology, 2012 Background The positioning and dynamics of vesicles and organelles, and thus the growth of plant cells, is mediated by the acto-myosin system. In Arabidopsis there are 13 class XI myosins which mediate vesicle and organelle transport in different cell ...
Ojangu Eve-Ly +6 more
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Unraveling the fastest myosin: Discovery history and structure-function relationships of algae Chara myosin XI [PDF]
Biophysics and PhysicobiologyPlant myosins have higher velocities than animal myosins. Among them, myosins in freshwater algae of the genus Chara have extremely high velocities. We have biochemically studied myosins that perform high-speed movements in the alga Chara.
Kohji Ito, Takeshi Haraguchi
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Molecular Motors in Blood–Brain Barrier Maintenance by Astrocytes [PDF]
Brain SciencesThe blood–brain barrier (BBB) comprises distinct cell types, including endothelial cells, pericytes, and astrocytes, and is essential for central nervous system (CNS) homeostasis by selectively regulating molecular transport and maintaining integrity. In
Ana Filipa Sobral +4 more
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Single-molecule fluorescence microscopy reveals regulatory mechanisms of MYO7A-driven cargo transport in stereocilia of live inner ear hair cells [PDF]
Nature CommunicationsStereocilia are F-actin-based cylindrical protrusions on the apical surface of inner ear hair cells that function as biological mechanosensors of sound and acceleration.
Takushi Miyoshi +9 more
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Pathophysiology of human hearing loss associated with variants in myosins [PDF]
Frontiers in PhysiologyDeleterious variants of more than one hundred genes are associated with hearing loss including MYO3A, MYO6, MYO7A and MYO15A and two conventional myosins MYH9 and MYH14. Variants of MYO7A also manifest as Usher syndrome associated with dysfunction of the
Takushi Miyoshi +4 more
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Switch-2 determines Mg2+ADP-release kinetics and fine-tunes the duty ratio of Dictyostelium class-1 myosins [PDF]
Frontiers in PhysiologyThough myosins share a structurally conserved motor domain, single amino acid variations of active site elements, including the P-loop, switch-1 and switch-2, which act as nucleotide sensors, can substantially determine the kinetic signature of a myosin,
Ralph P. Diensthuber +4 more
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Long-tailed class I myosins rely on tail-mediated phosphoinositide recognition for specific membrane recruitment [PDF]
Cell Communication and SignalingBackground Class I myosins are essential mediators of membrane–cytoskeleton interactions that support key cellular processes such as endocytosis, secretion, intracellular trafficking, and mitosis.
Girish Rajendraprasad +8 more
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Are the class 18 myosins Myo18A and Myo18B specialist sarcomeric proteins? [PDF]
Frontiers in PhysiologyInitially, the two members of class 18 myosins, Myo18A and Myo18B, appeared to exhibit highly divergent functions, complicating the assignment of class-specific functions.
Markus Horsthemke +3 more
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Gliding motility of the diatom Craspedostauros australis coincides with the intracellular movement of raphid-specific myosins [PDF]
Communications BiologyRaphid diatoms are one of the few eukaryotes capable of gliding motility, which is remarkably fast and allows for quasi-instantaneous directional reversals.
Metin G. Davutoglu +9 more
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The class II myosin MYH4 safeguards genome integrity and suppresses tumor progression [PDF]
The Journal of Clinical InvestigationLoss-of-function mutations in genome maintenance genes fuel tumorigenesis through increased genomic instability. A subset of these tumor suppressors are challenging to identify due to context dependency, including functional interactions with other genes
Jayashree Thatte +17 more
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