Results 11 to 20 of about 20,285 (238)

Flexibility within the Heads of Muscle Myosin-2 Molecules [PDF]

open access: yes, 2014
We show that negative-stain electron microscopy and image processing of nucleotide-free (apo) striated muscle myosin-2 subfragment-1 (S1), possessing one light chain or both light chains, is capable of resolving significant amounts of structural detail ...
Azzu   +66 more
core   +2 more sources

Insights into the origin of metazoan filopodia and microvilli. [PDF]

open access: yes, 2013
Filopodia are fine actin-based cellular projections used for both environmental sensing and cell motility, and they are essential organelles for metazoan cells. In this study, we reconstruct the origin of metazoan filopodia and microvilli.
Burkhardt, Pawel   +6 more
core   +2 more sources

Percolation with trapping mechanism drives active gels to the critically connected state

open access: yes, 2015
Cell motility and tissue morphogenesis depend crucially on the dynamic remodelling of actomyosin networks. An actomyosin network consists of an actin polymer network connected by crosslinker proteins and motor protein myosins that generate internal ...
Lee, Chiu Fan, Pruessner, Gunnar
core   +1 more source

CARMIL family proteins as multidomain regulators of actin-based motility [PDF]

open access: yes, 2017
CARMILs are large multidomain proteins that regulate the actin-binding activity of capping protein (CP), a major capper of actin filament barbed ends in cells.
Cooper, John A   +2 more
core   +2 more sources

Spatial Organization of the Cytoskeleton enhances Cargo Delivery to Specific Target Areas on the Plasma Membrane of Spherical Cells [PDF]

open access: yes, 2016
Intracellular transport is vital for the proper functioning and survival of a cell. Cargo (proteins, vesicles, organelles, etc.) is transferred from its place of creation to its target locations via molecular motor assisted transport along cytoskeletal ...
Hafner, Anne E., Rieger, Heiko
core   +2 more sources

Mechanosensing in myosin filament solves a 60 years old conflict in skeletal muscle modeling between high power output and slow rise in tension

open access: yes, 2016
Almost 60 years ago Andrew Huxley with his seminal paper \cite{Huxley1957} laid the foundation of modern muscle modeling, linking chemical events to mechanical performance.
Marcucci, Lorenzo, Reggiani, Carlo
core   +1 more source

Structures of smooth muscle myosin and heavy meromyosin in the folded, shutdown state [PDF]

open access: yes, 2007
Remodelling of the contractile apparatus within smooth muscle cells is an essential process that allows effective contractile activity over a wide range of cell lengths.
Ankrett   +60 more
core   +1 more source

Teaming up: from motors to people. [PDF]

open access: yes, 2013
When I reflect on how I became a cell biologist and why I love being one today, one thing that comes to mind is the many terrific collaborations I have had.
Reck-Peterson, Samara L
core   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

Two essential light chains regulate the MyoA lever arm to promote Toxoplasma gliding motility [PDF]

open access: yes, 2015
Key to the virulence of apicomplexan parasites is their ability to move through tissue and to invade and egress from host cells. Apicomplexan motility requires the activity of the glideosome, a multicomponent molecular motor composed of a type XIV myosin,
Alonso, Hernan   +8 more
core   +2 more sources

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