Results 21 to 30 of about 20,285 (238)

Mammalian Myosin-18A, a Highly Divergent Myosin [PDF]

Journal of Biological Chemistry, 2013
The Mus musculus myosin-18A gene is expressed as two alternatively spliced isoforms, α and β, with reported roles in Golgi localization, in maintenance of cytoskeleton, and as receptors for immunological surfactant proteins. Both myosin-18A isoforms feature a myosin motor domain, a single predicted IQ motif, and a long coiled-coil reminiscent of myosin-
Stephanie Guzik-Lendrum, Earl Homsher, Earl Homsher, Yi Yang, Yasuharu Takagi, Neil Billington, James R. Sellers, Peter J. Knight, Sarah M. Heissler   +8 more
openaire   +3 more sources

The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise

FEBS Open Bio, EarlyView.
Frailty syndrome exacerbates skeletal muscle degeneration via increased ECM deposition and myofiber loss. This study, using a murine model, demonstrates that endurance exercise attenuates these histopathological alterations, preserving muscle integrity. Findings support exercise as a viable strategy to counteract frailty‐induced musculoskeletal decline
Fujue Ji, Hae Sung Lee, Haesung Lee, Jong‐Hee Kim   +3 more
wiley   +1 more source

UDP‐glucose dehydrogenase variants cause dystroglycanopathy

Annals of Clinical and Translational Neurology, EarlyView.
Abstract UDP‐glucose dehydrogenase (UGDH) variants have been associated with hypotonia, developmental delay, and epilepsy. We report the first pathologic evidence of dystroglycanopathy in siblings with UGDH variants. Both presented around 6 months with developmental delay and elevated creatinine kinase.
Anna M. Reelfs, Carrie M. Stephan, Theresa M. Czech, Mary O. Cox, Soumya Joseph, Benjamin W. Darbro, Steven A. Moore, Kevin P. Campbell, Katherine D. Mathews   +8 more
wiley   +1 more source

Molecular motors: design, mechanism and control

, 2008
Biological functions in each animal cell depend on coordinated operations of a wide variety of molecular motors. Some of the these motors transport cargo to their respective destinations whereas some others are mobile workshops which synthesize ...
Chowdhury, Debashish
core   +1 more source

Biologically‐Inspired Melt Electrowriting for the Generation of Highly Biomimetic Functional Myocardium

Advanced Functional Materials, EarlyView.
In this work, melt electrowriting is used to fabricate a 3D printed scaffold design that generates engineered cardiac tissues with in‐plane contraction, mimicking natural myocardium. It is shown that these tissues display advanced maturation and functionality.
Olalla Iglesias‐García, María Flandes‐Iparraguirre, Pilar Montero‐Calle, Ricardo M. Rosales, Asier Ullate‐Agote, Andrea Sánchez‐Bueno, Eduardo Larequi, Ilazki Anaut‐Lusar, Nicolás Laita, Aida Oliván‐Viguera, Elena Iglesias, Gloria Abizanda, Patxi San Martín‐Úriz, Paula Aguirre‐Ruiz, Xabier L. Aranguren, Manuel García de Yébenes, Juan José Gavira, Miguel Ángel Martínez, Estefanía Peña, Manuel Doblaré, Elena M. de‐Juan‐Pardo, Esther Pueyo, Felipe Prosper, Manuel M. Mazo Vega   +23 more
wiley   +1 more source

Calmodulin-like proteins localized to the conoid regulate motility and cell invasion by Toxoplasma gondii [PDF]

, 2017
Toxoplasma gondii contains an expanded number of calmodulin (CaM)-like proteins whose functions are poorly understood. Using a combination of CRISPR/Cas9-mediated gene editing and a plant-like auxin-induced degron (AID) system, we examined the roles of ...
A Alaganan, A Graindorge, A Herm-Gotz, A Herm-Gotz, A Kreidenweiss, AJ Holland, AK Wernimont, AL Chen, AS Paul, AT Heaslip, B Shen, B Shen, BA Fox, BJ Foth, Bryan Anthony, CR Garcia, CS Bookwalter, D Jacot, D Jacot, D Soldati, DL Alexander, Dominique Soldati-Favre, E Nagayasu, EF Pettersen, F Delbac, GL Starnes, Isabelle Q. H. Phan, J Peng, J Soding, JL Burg, JL Gifford, JM Dobrowolski, K Frenal, K Frenal, K Hu, K Hu, K Nagamune, K Nishimura, Kevin M. Brown, KJ Roux, KM Brown, KM Brown, KM Skillman, KM Skillman, L Florens, L. David Sibley, LD Saffer, LD Sibley, Lisa L. Drewry, LL Drewry, M Meissner, M Meissner, MG Del Carmen, MH Huynh, MJ Wichroski, MJ Williams, MS Behnke, N Andenmatten, N Philip, NJ Katris, NS Morrissette, O Billker, P Bastin, P Kursula, RL Dunbrack Jr, RY Gaji, S Besteiro, S Egarter, S Håkansson, S Long, S Lourido, S Lourido, Shaojun Long, SM Heissler, SM Sidik, SM Sidik, V Polonais, VB Carruthers, VB Carruthers, VB Carruthers, VB Carruthers, VB Carruthers, Y Song, Y Yang   +83 more
core   +4 more sources

3D (Bio) Printing Combined Fiber Fabrication Methods for Tissue Engineering Applications: Possibilities and Limitations

Advanced Functional Materials, EarlyView.
Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana, Indra Apsite, Leonid Ionov   +2 more
wiley   +1 more source

Coupling biochemistry and mechanics in cell adhesion: a model for inhomogeneous stress fiber contraction

, 2007
Biochemistry and mechanics are closely coupled in cell adhesion. At sites of cell-matrix adhesion, mechanical force triggers signaling through the Rho-pathway, which leads to structural reinforcement and increased contractility in the actin cytoskeleton.
Achim Besser, Bartelt D C, Butler T M, Fung Y C, Huxley A F, Klipp E, Lo C-M, Mijailovich S M, Murray J D, Nagamoto H, Nunnally M H, Pato M D, Pollard T D, Ulrich S Schwarz, Umemoto S   +14 more
core   +1 more source

The role of myosin 1c and myosin 1b in surfactant exocytosis [PDF]

Journal of Cell Science, 2016
ABSTRACT Actin and actin-associated proteins have a pivotal effect on regulated exocytosis in secretory cells and influence pre-fusion as well as post-fusion stages of exocytosis. Actin polymerization on secretory granules during the post-fusion phase (formation of an actin coat) is especially important in cells with large secretory ...
Kittelberger, N, Breunig, M, Martin, R, Knölker, H, Miklavc, P   +4 more
openaire   +3 more sources

Probing Early Particle‐Cell Membrane Interactions via Single‐Cell and Single‐Particle Interaction Analysis

Advanced Functional Materials, EarlyView.
The pre‐internalization phase of endocytosis remains poorly characterized at single‐cell levels. Single‐cell pre‐internalization mechanics are investigated using advanced robotic techniques. Cancer cells exhibit biphasic adhesion – rapid initial binding followed by reinforcement – while fibroblasts show gradual engagement.
Houari Bettahar, Christos Tapeinos, Oğulcan Işıtman, Carmine D'Amico, Alexandra Correia, Hélder A. Santos, Quan Zhou   +6 more
wiley   +1 more source