Results 1 to 10 of about 2,314 (212)

Antibody-dependent enhancement of toxicity of myotoxin II from Bothrops asper [PDF]

Nature Communications
Improved therapies are needed against snakebite envenoming, which kills and permanently disables thousands of people each year. Recently developed neutralizing monoclonal antibodies against several snake toxins have shown promise in preclinical rodent ...
Christoffer V. Sørensen, Julián Fernández, Anna Christina Adams, Helen H. K. Wildenauer, Sanne Schoffelen, Line Ledsgaard, Manuela B. Pucca, Michael Fiebig, Felipe A. Cerni, Tulika Tulika, Bjørn G. Voldborg, Aneesh Karatt-Vellatt, J. Preben Morth, Anne Ljungars, Lise M. Grav, Bruno Lomonte, Andreas H. Laustsen   +16 more
doaj   +9 more sources

Myotoxin-3 from the Pacific Rattlesnake Crotalus oreganus oreganus Venom Is a New Microtubule-Targeting Agent [PDF]

Molecules, 2022
Microtubule targeting agents (MTA) are anti-cancer molecules that bind tubulin and interfere with the microtubule functions, eventually leading to cell death.
María Cecilia González García, Caroline Radix, Claude Villard, Gilles Breuzard, Pascal Mansuelle, Pascale Barbier, Philipp O. Tsvetkov, Harold De Pomyers, Didier Gigmes, François Devred, Hervé Kovacic, Kamel Mabrouk, José Luis   +12 more
doaj   +3 more sources

Molecular Architecture of the Antiophidic Protein DM64 and its Binding Specificity to Myotoxin II From Bothrops asper Venom [PDF]

Frontiers in Molecular Biosciences, 2022
DM64 is a toxin-neutralizing serum glycoprotein isolated from Didelphis aurita, an ophiophagous marsupial naturally resistant to snake envenomation. This 64 kDa antitoxin targets myotoxic phospholipases A2, which account for most local tissue damage of ...
Barbara S. Soares, Surza Lucia G. Rocha, Viviane A. Bastos, Diogo B. Lima, Paulo C. Carvalho, Fabio C. Gozzo, Borries Demeler, Borries Demeler, Borries Demeler, Tayler L. Williams, Janelle Arnold, Amy Henrickson, Thomas J. D. Jørgensen, Tatiana A. C. B. Souza, Jonas Perales, Richard H. Valente, Bruno Lomonte, Francisco Gomes-Neto, Ana Gisele C. Neves-Ferreira   +18 more
doaj   +3 more sources

Structure-based design of an antibacterial peptide from the Myotoxin II sequence, evaluating its effectiveness against Gram-negative bacteria and its safety [PDF]

Scientific Reports
Bacterial resistance poses a significant public health challenge, particularly for pathogens prioritized by the World Health Organization, such as carbapenem-resistant Escherichia coli.
Tatiana Huertas, Diana Millán, Angela V. Fonseca-Benítez, James Guevara-Pulido   +3 more
doaj   +3 more sources

Pharmacological Properties of Vochysia Haenkeana (Vochysiaceae) Extract to Neutralize the Neuromuscular Blockade Induced by Bothropstoxin-I (Lys49 Phospholipase A2) Myotoxin [PDF]

Advanced Pharmaceutical Bulletin, 2017
Purpose: Bothrops snakes are responsible for more than 70 % of snakebites every year in Brazil and their venoms cause severe local and systemic damages. The pharmacological properties of medicinal plants have been widely investigated in order to discover
Carolina Harder, Akila Lara de Oliveira, Andreia Borges Scriboni, Adélia Cristina Oliveira Cintra, Raphael Schezaro-Ramos, Márcio Galdino dos Santos, Karina Cogo-Müller, Regina Yuri Hashimoto Miura, Rafael Stuani Floriano, Sandro Rostelato-Ferreira, Yoko Oshima-Franco   +10 more
doaj   +4 more sources

SDS-induced hexameric oligomerization of myotoxin-II from Bothrops asper assessed by sedimentation velocity and nuclear magnetic resonance. [PDF]

Eur Biophys J, 2023
Henrickson A, Montina T, Hazendonk P, Lomonte B, Neves-Ferreira AGC, Demeler B.   +5 more
europepmc   +4 more sources

In Vivo Neutralization of Myotoxin II, a Phospholipase A₂ Homologue from Bothrops asper Venom, Using Peptides Discovered via Phage Display Technology. [PDF]

ACS Omega, 2022
Many snake venom toxins cause local tissue damage in prey and victims, which constitutes an important pathology that is challenging to treat with existing antivenoms.
Laustsen AH, Gless BH, Jenkins TP, Meyhoff-Madsen M, Bjärtun J, Munk AS, Oscoz S, Fernández J, Gutiérrez JM, Lomonte B, Lohse B.   +10 more
europepmc   +2 more sources

Cytotoxicity of snake venom Lys49 PLA2-like myotoxin on rat cardiomyocytes ex vivo does not involve a direct action on the contractile apparatus

Scientific Reports, 2021
Viperid snake venoms contain a unique family of cytotoxic proteins, the Lys49 PLA2 homologs, which are devoid of enzymatic activity but disrupt the integrity of cell membranes.
Alfredo Jesús López-Dávila, Natalie Weber, Theresia Kraft, Faramarz Matinmehr, Mariela Arias-Hidalgo, Julián Fernández, Bruno Lomonte, José María Gutiérrez   +7 more
doaj   +2 more sources

Snakes on a plain: biotic and abiotic factors determine venom compositional variation in a wide-ranging generalist rattlesnake [PDF]

BMC Biology, 2023
Background Snake venoms are trophic adaptations that represent an ideal model to examine the evolutionary factors that shape polymorphic traits under strong natural selection.
Cara F. Smith, Zachary L. Nikolakis, Kathleen Ivey, Blair W. Perry, Drew R. Schield, Neil R. Balchan, Joshua Parker, Kirk C. Hansen, Anthony J. Saviola, Todd A. Castoe, Stephen P. Mackessy   +10 more
doaj   +2 more sources

Snake venom defensins: Defining the structural and functional characteristics of the toxin family [PDF]

Journal of Structural Biology: X
Snake venom defensins are a toxin family found in rattlesnake venoms (Crotalus) which are comprised of crotamine-like peptides and myotoxins. Their tertiary structure resembles the β-defensin family structure.
David Melendez-Martinez, Adriana Morales-Martinez, Iliana Vanessa Almanza-Campos, Francisco Sierra-Valdez, Miguel Borja, Alejandro Carbajal-Saucedo, Christopher L. Parkinson, Jorge Benavides   +7 more
doaj   +2 more sources