Why myotoxin-containing snake venoms possess powerful nucleotidases?
Biochemical and Biophysical Research Communications, 2012 The venom of the snake Bothrops asper causes muscle necrosis, pain and inflammation. This venom contains myotoxins which cause an increase in intracellular Ca(2+) concentration and release of K(+) and ATP from myotubes. ATP is a key danger molecule that triggers a variety of reactions, including activation of the innate immune response. Here, using ATP-
Paola Caccin +8 more
semanticscholar +9 more sources
Inducible deletion of endothelial cell Efnb2 delays capillary regeneration and attenuates myofibre reinnervation following myotoxin injury in mice. [PDF]
J PhysiolAcute injury of skeletal muscle disrupts myofibres, microvessels and motor innervation. Myofibre regeneration is well characterized, however its relationship with the regeneration of microvessels and motor nerves is undefined.
Morton AB +6 more
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Journal of Venomous Animals and Toxins including Tropical Diseases, 2015 Background Phospholipases A 2 (PLA 2 s) are abundant components of snake venoms that have been extensively studied due to their pharmacological and pathophysiological effects on living organisms.
Cássio Prinholato da Silva +6 more
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N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin [PDF]
Scientific Reports, 2016 Neprilysin (NEP) and endothelin converting enzyme-1 (ECE-1) are two enzymes that degrade amyloid beta in the brain. Currently there are no molecules to stimulate the activity of these enzymes.
A. Ian Smith +12 more
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A plethora of rodents: Rattlesnake predators generate unanticipated patterns of venom resistance in a grassland ecosystem [PDF]
Toxicon: XPredation has the potential to impart strong selective pressures on organisms within their environments, resulting in adaptive changes in prey that minimize risk of predation.
Neil R. Balchan +2 more
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A Lys49-PLA2 myotoxin of Bothrops asper triggers a rapid death of macrophages that involves autocrine purinergic receptor signaling [PDF]
Cell Death and Disease, 2012 Lys49-PLA2 myotoxins, an important component of various viperid snake venoms, are a class of PLA2-homolog proteins deprived of catalytic activity.
Fiorella Tonello +7 more
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Intramuscular delivery of mRNA-encoded single-chain variable fragments prevents myotoxin II-induced skeletal muscle damage in a preclinical model [PDF]
Trends in BiotechnologyJosé R. Almeida +13 more
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Regulation of injury-induced skeletal myofiber regeneration by glucose transporter 4 (GLUT4) [PDF]
Skeletal MuscleBackground Insulin resistance and type 2 diabetes impair cellular regeneration in multiple tissues including skeletal muscle. The molecular basis for this impairment is largely unknown.
Tyler J. Sermersheim +5 more
doaj +2 more sources
Lys49 myotoxin from the Brazilian lancehead pit viper elicits pain through regulated ATP release [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2017 Chuchu Zhang +4 more
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Animal Venoms as Peptide Libraries for the Discovery of Antiglioblastoma Agents. [PDF]
Biochem Res IntGlioblastoma is one of the most aggressive and widely recognized types of brain tumors, characterized by significant cellular and molecular diversity and an inherently aggressive nature. The treatment remains highly challenging, with limited effectiveness and persistently low survival rates.
Santiago LR +5 more
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