Results 31 to 40 of about 2,964 (225)

A plethora of rodents: Rattlesnake predators generate unanticipated patterns of venom resistance in a grassland ecosystem [PDF]

Toxicon: X
Predation has the potential to impart strong selective pressures on organisms within their environments, resulting in adaptive changes in prey that minimize risk of predation.
Neil R. Balchan, Cara F. Smith, Stephen P. Mackessy   +2 more
doaj   +2 more sources

Spatially Resolved Profiling of Compartmentalized Muscle and Brain Inflammation. [PDF]

Eur J Immunol
This review summarizes emerging spatially resolved multi‐omics approaches revealing organized cell–cell interactions in skeletal muscle and brain inflammation. These tools uncover radiating molecular programs and niche‐specific immunopathology that shape cellular reactivity and vulnerability.
Dobbertin T, Schirmer L.
europepmc   +2 more sources

The Effect of Anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) Human Autoantibodies on Muscle Regeneration in Mice. [PDF]

Muscle Nerve
ABSTRACT Introduction/Aims Anti‐3‐hydroxy‐3‐methylglutaryl‐CoA reductase (HMGCR) autoantibodies (aAbs) are pathogenic in immune‐mediated necrotizing myopathy (IMNM), partly through complement activation. C5 inhibition did not restore muscle strength in mice or patients with overt IMNM, suggesting additional pathogenic mechanisms.
Julien S, Tomasevic H, Jaworski T, Zoubairi R, Martinet J, Drouot L, Boyer O.   +6 more
europepmc   +2 more sources

Regulation of injury-induced skeletal myofiber regeneration by glucose transporter 4 (GLUT4) [PDF]

Skeletal Muscle
Background Insulin resistance and type 2 diabetes impair cellular regeneration in multiple tissues including skeletal muscle. The molecular basis for this impairment is largely unknown.
Tyler J. Sermersheim, LeAnna J. Phillips, Parker L. Evans, Barbara B. Kahn, Steven S. Welc, Carol A. Witczak   +5 more
doaj   +2 more sources

A new crotamine-like from the rattlesnake (Crotalus durissus cumanensis) venom causing damages: Qualitative and Quantitative Cytotoxic Studies on subcellular and neuromuscular structures

Revista Científica, 2022
A quantitative model to expose the adrenal gland sub-cellular alterations produced by crotamine-like (C-L) from rattlesnake venom during 3, 6 and 24 hours (h), and also qualitative changes on mice neuromuscular structures in vivo were observed and ...
Estefanie García, Hector José Finol†, Roschman González, Alexis Rodríguez-Acosta   +3 more
doaj   +1 more source

Synergism between basic Asp49 and Lys49 phospholipase A2 myotoxins of viperid snake venom in vitro and in vivo. [PDF]

PLoS ONE, 2014
Two subtypes of phospholipases A2 (PLA2s) with the ability to induce myonecrosis, 'Asp49' and 'Lys49' myotoxins, often coexist in viperid snake venoms. Since the latter lack catalytic activity, two different mechanisms are involved in their myotoxicity ...
Diana Mora-Obando, Julián Fernández, Cesare Montecucco, José María Gutiérrez, Bruno Lomonte   +4 more
doaj   +1 more source

Heterologous expression of the antimyotoxic protein DM64 in Pichia pastoris. [PDF]

PLoS Neglected Tropical Diseases, 2017
Snakebite envenomation is a neglected condition that constitutes a public health problem in tropical and subtropical countries, including Brazil.
Saulo Martins Vieira, Surza Lucia Gonçalves da Rocha, Ana Gisele da Costa Neves-Ferreira, Rodrigo Volcan Almeida, Jonas Perales   +4 more
doaj   +1 more source

Bacterial Lipopolysaccharides Exacerbate Neurogenic Heterotopic Ossification Development

Journal of Bone and Mineral Research, Volume 38, Issue 11, Page 1700-1717, November 2023., 2023
ABSTRACT Neurogenic heterotopic ossifications (NHO) are heterotopic bones that develop in periarticular muscles after severe central nervous system (CNS) injuries. Several retrospective studies have shown that NHO prevalence is higher in patients who suffer concomitant infections.
Marjorie Salga, Selwin G Samuel, Hsu‐Wen Tseng, Laure Gatin, Dorothée Girard, Bastien Rival, Valérie Barbier, Kavita Bisht, Svetlana Shatunova, Charlotte Debaud, Ingrid G Winkler, Julie Paquereau, Aurélien Dinh, Guillaume Genêt, Sébastien Kerever, Paer‐Sélim Abback, Sébastien Banzet, François Genêt, Jean‐Pierre Lévesque, Kylie A Alexander   +19 more
wiley   +1 more source

Isolation and characterization of a myotoxin from Bothrops brazili Hoge, 1953 Hoge, 1953 snake venom (Ophidia: Viperidae).

Revista Peruana de Biología, 2014
A myotoxin from the venom of the snake Bothrops brazili has been purified by ion-exchange chromatography on CM-Sephadex C-50 with 0,05 M ammonium acetate buffer pH 7.
Carmen Pantigoso, Enrique Escobar, Armando Yarlequé   +2 more
doaj   +1 more source

Sex differences in skeletal muscle size, function, and myosin heavy chain isoform expression during post‐injury regeneration in mice

Physiological Reports, Volume 11, Issue 16, August 2023., 2023
Abstract Skeletal muscle regeneration is an essential process to restore muscle function after injury and is influenced by various factors. Despite the known importance of sex hormones in muscle regeneration, whether and what sex difference exists in this process is still unclear.
Jae‐Sung You, Pallob Barai, Jie Chen
wiley   +1 more source