Results 131 to 140 of about 975 (184)
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Specific in Vitro Biological Activity of Snake Venom Myotoxins
Journal of Neurochemistry, 1993Abstract: Some snake venoms contain toxins that are reported to be selective for damaging muscle. This specificity can be used to design experiments intended to eliminate muscle. We studied the small myotoxins and fractions IV and V of Bothrops nummifer venom to evaluate their direct effect on cultured muscle cells, neurons, macrophages, and a ...
Eleonora Katz, Juan L Brusés, G Pilar
exaly +3 more sources
Myotoxin a, Crotamine and Defensin Homologs in Reptile Venoms
, 2021 Snakebite envenomation is common in all inhabited continents of the world, with more than 100,000 fatalities occurring every year. Depending on the snake species involved, envenomation includes often disabling intense local tissue damage with inflammation, pain and myonecrosis, caused in part by molecules known as myotoxins.
Porta, Lucas C +3 more
openaire +2 more sources
Cellular and Molecular Life Sciences, 2009 Snake myotoxins have a great impact on human health worldwide. Most of them adopt a phospholipase A2 fold and occur in two forms which often co-exist in the same venom: the Asp49 toxins hydrolyse phospholipids, whilst Lys49 toxins are enzymatically ...
Luis Alberto Ponce Soto +2 more
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Bothrops Snake Myotoxins Induce a Large Efflux of ATP and Potassium With Spreading of Cell Damage and Pain [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2010 Myotoxins play a major role in the pathogenesis of the envenomations caused by snake bites in large parts of the world where this is a very relevant public health problem.
Paola Pizzo +2 more
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Isolation of Basic Myotoxins From Bothrops moojeni and Bothrops Atrox Snake Venoms
Toxicon, 1990 Three myotoxins, one from the venom of Bothrops atrox and two from the venom of B. moojeni, were isolated by ion-exchange chromatography on CM-Sephadex C-25. The three toxins are basic proteins with an estimated mol. wt of about 13,500, and similar amino
José María Gutiérrez +2 more
exaly +2 more sources
Snake Venom Lys49 Myotoxins: From Phospholipases A2 to Non-Enzymatic Membrane Disruptors
Toxicon, 2012 Snake venoms often contain toxins that cause a rapid necrosis of skeletal muscle fibers, referred to as myotoxins. The most common among them are phospholipases A2 (PLA2s), enzymes that have two independent evolutionary origins in snake venoms.
Bruno Lomonte
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Effect of Calcineurin Inhibitors on Myotoxic Activity of Crotoxin and Bothrops Asper Phospholipase A2 Myotoxins in Vivo and in Vitro [PDF]
Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology, 2006 Previous studies have shown that calcineurin activity plays a critical role in the myotoxic activity induced by crotoxin (CTX), a group II phospholipase A2 (PLA2) with neurotoxic and myotoxic actions.
Igor L Baptista +2 more
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Comparative Biochemistry and Physiology Part A, Molecular & Integrative Physiology, 1998 (1) Venom pools from Bothrops neuwiedi (Bn) and from two subspecies, namely Bothrops neuwiedi pauloensis (Bnp) and Bothrops neuwiedi urutu (Bnu), collected in the States of São Paulo (SP) and Minas Gerais (MG), Brazil, were electrophoretically examined ...
Marcos R M Fontes +2 more
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Toxicon, 1991 An enzyme-immunoassay (EIA) for the quantitation of antibodies against myotoxins present in the venoms of Bothrops asper (Costa Rica), B. atrox (Colombia) and B. moojeni (Brazil), was developed. This EIA was utilized for the evaluation of four antivenoms
José María Gutiérrez +2 more
exaly +2 more sources