Results 141 to 150 of about 975 (184)

The Effect of Myotoxins Isolated From Bothrops Snake Venoms on Multilamellar Liposomes: Relationship to Phospholipase A2, Anticoagulant and Myotoxic Activities

Biochimica Et Biophysica Acta - Biomembranes, 1991
The effect of four myotoxins isolated from Bothrops snake venoms on the release of peroxidase trapped in large multilamellar liposomes was studied and correlated to their phospholipase A2, myotoxic and anticoagulant activities.
Cecilia Diaz, José María Gutiérrez, Bruno Lomonte   +2 more
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Structural, Biological and Biochemical Studies of MyotoxinaAnd Homologous Myotoxins

Journal of Toxicology: Toxin Reviews, 1997
AbstractMyotoxin a and a group of closely related, small, basic toxins cause myonecrotic destruction of muscle tissue upon envenomation. The sarcoplasmic reticulum swells and eventually breaks down to small vesicles. Degeneration of myofibrils and myofilaments ensues and loss of the classic striation pattern is apparent.
A. L. Bieber, D. Nedelkov
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Binding of myotoxin a to cultured muscle cells

Toxicon, 1993
The binding of radiolabeled myotoxin a to various cultured cell lines was evaluated. One rat skeletal muscle-derived cell line, L8, bound substantially more myotoxin a than did all all other cell lines examined. Several biophysical parameters of myotoxin a-L8 binding were determined. Binding was saturable with a moderate binding affinity.
B, Baker, A T, Tu, J L, Middlebrook
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Synthetic polypeptide crotamine: characterization as a myotoxin and as a target of combinatorial peptides

Journal of Molecular Medicine, 2021
Crotamine is a rattlesnake-derived toxin that causes fast-twitch muscle paralysis. As a cell-penetrating polypeptide, crotamine has been investigated as an experimental anti-cancer and immunotherapeutic agent. We hypothesized that molecules targeting crotamine could be designed to study its function and intervene in its adverse activities.
Celine Pompeia, Eduardo Osório Frare, Steve Peigneur, Jan Tytgat, Álvaro Prieto da Silva, Eduardo Brandt de Oliveira, Alexandre Pereira, Irina Kerkis, Mikhail G. Kolonin   +8 more
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Structure-function relationship of myotoxin a using peptide fragments

Archives of Biochemistry and Biophysics, 1992
Myotoxin a, a small basic polypeptide isolated from the venom of prairie rattlesnake (Crotalus viridis viridis), has been shown to bind to sarcoplasmic reticulum (SR) Ca(2+)-ATPase. The attachment of myotoxin a to Ca(2+)-ATPase is believed to cause uncoupling of the calcium pump.
B, Baker, P, Utaisincharoen, A T, Tu
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Similarities and differences in mechanisms of cardiotoxins, melittin and other myotoxins

Toxicon, 1996
Myonecrosis induced in vivo by cardiotoxin, melittin, and Asp49 and Lys49 phospholipase A2 (PLA2) myotoxins involves rapid lysis of the sarcolemma, myofibril clumping, and hypercontraction of sarcomeres. In contrast, skeletal muscle necrosis induced by crotamine and myotoxin a is much slower, consisting of mitochondrial and sarcoplasmic reticulum ...
J E, Fletcher, M, Hubert, S J, Wieland, Q H, Gong, M S, Jiang   +4 more
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Effects of myotoxins on skeletal muscle fibers

Progress in Neurobiology, 1995
This review highlights various aspects of a number of experimental myological alterations, induced by different chemical toxicants, including anticholinesterase, colchicine, vincristine, chloroquine, tetanus toxin, botulinum toxin, reserpine and emetine.
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Interaction of myotoxin with a artificial membranes: Raman spectroscopic investigations

Biochemistry, 1985
Myotoxin a from the venom of Crotalus viridis viridis (prairie rattlesnake) is a small protein which is responsible for myonecrosis. It is a basic protein with 42 amino acid residues of known sequence. Three disulfide bonds give it a highly compact structure.
W K, Liddle, A T, Tu
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Purification and properties of a myotoxin from Conus geographus venom

Archives of Biochemistry and Biophysics, 1978
Abstract Previous studies (R. Endean et al. (1974), Toxicon12: 131–138) indicate that whole venom from the marine mollusc Conus geographus directly inhibits skeletal muscle, leaving peripheral nerves, cardiac and smooth muscle unaffected. A quantitative bioassay has been used to detect and measure biologically active myotoxin. By using chromatography
L J, Cruz, W R, Gray, B M, Olivera
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Detection of myotoxin a-like proteins in various snake venoms

Toxicon, 1988
Ninety-five venom samples from eight snake genera (Agkistrodon, Bitis, Bothrops, Calloselasma, Crotalus, Sistrurus, Naja and Vipera) including venoms of Crotalus species of different geographical origin were assayed using immunodiffusion or an ELISA for the presence of the small basic protein, myotoxin alpha, known to cause muscle necrosis.
M A, Bober, J L, Glenn, R C, Straight, C L, Ownby   +3 more
openaire   +2 more sources