Results 101 to 110 of about 18,015 (263)

Stac3 Inhibits Myoblast Differentiation into Myotubes

PLoS ONE, 2014
The functionally undefined Stac3 gene, predicted to encode a SH3 domain- and C1 domain-containing protein, was recently found to be specifically expressed in skeletal muscle and essential to normal skeletal muscle development and contraction. In this study we determined the potential role of Stac3 in myoblast proliferation and differentiation, two ...
Ge, Xiaomei, Zhang, Yafei, Park, Sungwon, Cong, Xiaofei, Gerrard, David E., Jiang, Honglin   +5 more
openaire   +5 more sources

Protective effects of adiponectin receptor agonists against equine lamellar endoplasmic reticulum stress

Equine Veterinary Journal, EarlyView.
Abstract Background Lamellar endoplasmic reticulum (ER) stress occurs in hyperinsulinemia‐associated and sepsis‐related laminitis. Adiponectin is associated with reduced laminitis risk and inhibits ER stress in other species. Objectives To induce ER stress in ex vivo equine lamellar cells using pharmacological agents.
Marine A. Barnabé, Jonathan Elliott, Nicola J. Menzies‐Gow, Simon R. Bailey, Nicholas J. Bamford, Yu‐Mei Chang, Matthew C. Gage   +6 more
wiley   +1 more source

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

Motoneurons purified by cell sorting respond to two distinct activities in myotube-conditioned medium [PDF]

, 1984
Spinal motoneurons from chick embryos were purified by retrograde transport and fluorescence-activated cell sorting. Growth conditions for motoneurons were studied, with experiments focused on the effects of conditioned media from chick myotubes ...
Calof, Anne L, Reichardt, Louis F
core   +1 more source

A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside

Interdisciplinary Medicine, EarlyView.
This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione, Ana Talamillo, Juan M. Falcón‐Pérez   +2 more
wiley   +1 more source

Inhibition of Ornithine Decarboxylase 1 Mitigates Denervation‐Induced Muscle Atrophy by Suppressing Proteolysis and Preserving Muscle Stem Cell Homeostasis

Cell Proliferation, EarlyView.
Polyamine metabolism is innervation responsive and involved in denervation‐induced muscle atrophy. Inhibition of polyamine metabolism attenuates muscle atrophy by restraining proteolysis and preserving MuSCs homeostasis. Denervation‐induced activation of FAP‐derived FGF7 drives premature MuSCs activation, while DFMO suppresses this paracrine cue to ...
Mingming Zhang, Feifan Chang, Siliang Ge, Fuming Cao, Pincong Fu, Haobo Zhang, Ming Chen, Yi Li, Peifu Tang, Pengbin Yin   +9 more
wiley   +1 more source

Rotenone inhibits primary murine myotube formation via Raf-1 and ROCK2

, 2015
Rotenone (ROT) is a widely used inhibitor of complex I (CI), the first complex of the mitochondrial oxidative phosphorylation (OXPHOS) system. However, particularly at high concentrations ROT was also described to display off-target effects.
Wagenaars, J.A., Grefte, Sander, Willems, P.H., Jansen, R., Wagenaars, J.A.L., Willems, P.H.G.M., Wagenaars, Jori A.L., Koopman, W.J.H., Koopman, Werner J.H., Grefte, S., Willems, Peter H.G.M., Jansen, Renate   +11 more
core   +1 more source

Type 1 Interferons Inhibit Myotube Formation Independently of Upregulation of Interferon-Stimulated Gene 15 [PDF]

, 2014
Introduction: Type 1 interferon (IFN)-inducible genes and their inducible products are upregulated in dermatomyositis muscle. Of these, IFN-stimulated gene 15 (ISG15) is one of the most upregulated, suggesting its possible involvement in the pathogenesis
Greenberg, Steven, Franzi, Sara, Nazareno, Remedios, Salajegheh, Mohammad   +3 more
core   +1 more source

Resistance‐exercise‐induced stress intervenes in TGF‐β signaling by cooperatively downregulating nuclear αB‐crystallin and SMAD4 in human skeletal muscle fibers

The FEBS Journal, EarlyView.
Alpha‐crystallin B chain (CRYAB) has been reported to stabilize mothers against decapentaplegic homolog 4 (SMAD4) in transforming growth factor‐β (TGF‐β) signaling, enabling target gene transcription. We show nuclear CRYAB–SMAD4 interaction for the first time in human skeletal muscle fibers and its regulation by exercise.
Kirill Schaaf, Cassandra Duda, Tihomir Kostov, Patrick Diel, Käthe Bersiner, Wilhelm Bloch, Sebastian Gehlert, Daniel Jacko   +7 more
wiley   +1 more source

Transient expression of phosphatidylserine at cell-cell contact areas is required for myotube formation [PDF]

, 2001
Cell surface exposure of phosphatidylserine (PS) is shown to be part of normal physiology of skeletal muscle development and to mediate myotube formation.
van Heerde, W. L., Ramaekers, FCS, van den Hoff, M.J.B., Keers, C, Borgers, M, Schutte, B., Eijnde, S.M. van den, Henfling, MER, Ramaekers, F.C.S., Reutelingsperger, C.P.M., van Heerde, W.L., van den Hoff, MJB, Vermeij-Keers, C., Henfling, M. E., Reutelingsperger, C. P., Henfling, M.E.R., van den Eijnde, S. M., van den Eijnde, S.M., Borgers, M., Hoff, M.J. van den, van den Eijnde, SM, Schutte, H.K., Ramaekers, F. C., van Heerde, WL, Heerde, W.L. van, Henfling, M.E., Schutte, B, Reutelingsperger, ChPM, van den Hoff, M. J.   +28 more
core   +1 more source