Cells, 2021 Understanding the signaling pathways that regulate the final differentiation of human myoblasts is essential for successful cell transplantation and drug screening for the treatment of muscular dystrophy.
In Young Choi +4 more
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Elevated Circulating Ceramides 18:0 and 24:1 as a Risk Factor for Sarcopenia: In Vitro, Animal, and Clinical Evidence. [PDF]
J Cachexia Sarcopenia MuscleABSTRACT Background Ceramides have garnered considerable attention as pro‐aging bioactive lipids implicated in both metabolic dysfunction and musculoskeletal decline. Among these, C18:0 and C24:1 ceramides may play a role in the pathophysiology of sarcopenia, a key manifestation of age‐related deterioration.
Park SJ +15 more
europepmc +2 more sources
Systemic Drivers and Molecular Mechanisms of Sarcopenia in Aetiology-Specific End-Stage Liver Disease. [PDF]
J Cachexia Sarcopenia MuscleABSTRACT Background Patients with end‐stage liver disease (ESLD) often present with sarcopenia, defined as loss of skeletal muscle mass and quality, which is associated with reduced quality of life and increased mortality. However, the molecular mechanisms driving sarcopenia in ESLD are not fully understood and there are currently no therapeutic ...
Nicholson T +16 more
europepmc +2 more sources
The myogenic kinome: protein kinases critical to mammalian skeletal myogenesis
Skeletal Muscle, 2011 Myogenesis is a complex and tightly regulated process, the end result of which is the formation of a multinucleated myofibre with contractile capability.
Knight James DR, Kothary Rashmi
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Dedifferentiation of Mammalian Myotubes Induced by msx1 [PDF]
Cell, 2000 The process of cellular differentiation culminating in terminally differentiated mammalian cells is thought to be irreversible. Here, we present evidence that terminally differentiated murine myotubes can be induced to dedifferentiate. Ectopic expression of msx1 in C2C12 myotubes reduced the nuclear muscle proteins MyoD, myogenin, MRF4, and p21 to ...
Odelberg, Shannon J. +2 more
openaire +2 more sources
Micro Back-Markers on Thin Film of Scaffold to Measure Repetitive Local Contraction of Myotubes in Vitro [PDF]
Journal of Systemics, Cybernetics and Informatics, 2020 The repetitive contraction of the myotube has been measured by the local movement of micro-markers on the thin film of the scaffold during the electric stimulation in vitro.
Shigehiro Hashimoto, Yuta Saito
doaj
LanB1 Cooperates With Kon-Tiki During Embryonic Muscle Migration in Drosophila
Frontiers in Cell and Developmental Biology, 2022 Muscle development is a multistep process that involves cell specification, myoblast fusion, myotube migration, and attachment to the tendons. In spite of great efforts trying to understand the basis of these events, little is known about the molecular ...
Juan José Pérez-Moreno +6 more
doaj +1 more source
Oxaloacetate and Ketone Bodies Synergistically Promote Myoblast Differentiation in L6 Cells
MoleculesMalnutrition and aging are major factors that inhibit myoblast differentiation, leading to a decline in muscle function and contributing to sarcopenia development.
Yuji Onuki +4 more
doaj +1 more source
Regulation of myotube formation by the actin-binding factor drebrin
Skeletal Muscle, 2011 Background Myogenic differentiation involves cell-cycle arrest, activation of the muscle-specific transcriptome, and elongation, alignment and fusion of myoblasts into multinucleated myotubes.
Mancini Annalisa +5 more
doaj +1 more source
Metabolic flexibility is conserved in diabetic myotubes [PDF]
Journal of Lipid Research, 2007 The purpose of this study was to test the hypothesis that metabolic inflexibility is an intrinsic defect. Glucose and lipid oxidation were studied in human myotubes established from healthy lean and obese subjects and patients with type 2 diabetes (T2D).
openaire +4 more sources