Alteration of Oxidative stress and apoptotic markers alterations in the rat prefrontal cortex influence behavioral response induced by cisplatin and N-acetylcysteine in the tail suspension test [PDF]
Journal of Integrative Neuroscience, 2021 Cisplatin therapy is often accompanied by neurotoxicity manifestation, and since the prefrontal cortex is strongly involved in emotion regulation, the aim of this study was to analyze the alterations in the oxidative and apoptotic status of this brain
Rade Vukovic +5 more
doaj +2 more sources
N-acetylcysteine as an adjunctive treatment for smoking cessation: a randomized clinical trial [PDF]
Brazilian Journal of Psychiatry, 2020 Objective: This randomized controlled trial examined the efficacy and safety of N-acetylcysteine as an adjunctive treatment for smoking cessation. Methods: Heavy smokers were recruited from smoking cessation treatment for this 12- week randomized ...
Regina C.B.R. Machado +6 more
doaj +3 more sources
Topical Instillation of N-Acetylcysteine and N-Acetylcysteine Amide Impedes Age-Related Lens Opacity in Mice [PDF]
BiomoleculesCataracts, the leading cause of blindness globally, are caused by oxidative stress and inflammation, which disrupt lens transparency due to increased accumulation of reactive oxygen species (ROS) as well as protein and DNA damage during aging.
Hidetoshi Ishida +6 more
doaj +2 more sources
N-acetylcysteine Clinical Applications. [PDF]
CureusThis study aims to evaluate the therapeutic application of N-acetylcysteine (NAC) as a treatment or adjunct therapy for various medical conditions. While its efficacy in treating acetaminophen overdose, cystic fibrosis, and chronic obstructive pulmonary disease is well-established, emerging evidence suggests that NAC may also benefit a broader spectrum
Yahia Z, Yahia A, Abdelaziz T.
europepmc +3 more sources
Efficiency evaluation of Amlodipine combined with N-acetylcysteine on Indomethacin-induced gastritis in rats [PDF]
Research Results in Pharmacology, 2022 Introduction: It is a well-known phenomenon that nonsteroidal anti-inflammatory drugs cause gastric mucosal damage. Amlodipine is a third generation dihydropyridine-type calcium channel blocker; it can inhibit inflammatory cytokines and enhance ...
Yara Annouf, Shaza Al laham, Eyad Chatty
doaj +3 more sources
Stability Study of Parenteral N-Acetylcysteine, and Chemical Inhibition of Its Dimerization
Pharmaceuticals, 2023 Parenteral N-acetylcysteine has a wide variety of clinical applications, but its use can be limited by a poor chemical stability. We managed to control parenteral N-acetylcysteine stability, and to study the influence of additives on the decrease of N ...
Nicolas Primas +9 more
doaj +1 more source
Evaluation of N-acetylcysteine for the prevention of contrast-induced nephropathy [PDF]
Journal of Community Hospital Internal Medicine Perspectives, 2015 Background: Contrast-induced nephropathy (CIN) remains a leading cause of acute renal failure in hospitalized patients. N-Acetylcysteine has been studied previously for the prevention of CIN, resulting in mixed findings.
Sara K. Richter, Andrew J. Crannage
doaj +1 more source
The Role of N-Acetylcysteine in Obsessive-Compulsive (OCD) and Related Disorders
European Psychiatry, 2022 Introduction N-acetylcysteine is known for its uses in non-psychiatric conditions, such as paracetamol overdose and as a mucolytic. The rationale for its administration in psychiatric conditions is based on its ability reducing synaptic glutamate ...
J. Sá Couto +4 more
doaj +1 more source
Non-Intentional N-Acetylcysteine Overdose Associated with Cerebral Edema and Brain Death
Case Reports in Gastroenterology, 2023 N-acetylcysteine is the established treatment for acetaminophen toxicity. This medication’s complex dosing schedule engenders a high incidence of medication errors.
Emma E.M. Spence +4 more
doaj +1 more source
Better together? Treating traumatic brain injury with minocycline plus N-acetylcysteine
Neural Regeneration Research, 2022 Traumatic brain injury has a complex pathophysiology that produces both rapid and delayed brain damage. Rapid damage initiates immediately after injury. Treatment of traumatic brain injury is typically delayed many hours, thus only delayed damage can be ...
Siobhán Lawless, Peter J Bergold
doaj +1 more source