Results 101 to 110 of about 836,707 (292)

Spatiotemporal Dynamics of Central Nervous System Diseases: Advancing Translational Neuropathology via Single‐Cell and Spatial Multiomics

MedComm, Volume 6, Issue 9, September 2025.
Central nervous system (CNS) diseases are driven by spatiotemporally dynamic molecular networks. Single‐cell and spatial multiomics technologies dissect cellular heterogeneity, microenvironmental remodeling, and intercellular crosstalk. Integration of transcriptomic, epigenomic, proteomic, and metabolomic layers reveals disease‐associated regulatory ...
Mingkai Xia, Quan Liu, Wenli Zhang, Jinwen Ge, Zhigang Mei   +4 more
wiley   +1 more source

Edible Bird's Nest, an Asian Health Food Supplement, Possesses Skin Lightening Activities: Identification of N-Acetylneuraminic Acid as Active Ingredient

, 2015
Edible bird’s nest (EBN; Yan Wo), or cubilose, is originated from the salivary secretion of Aerodramus fuciphagus. In Asia, EBN is famous for its unproven skin lightening function. Here, we aim to reveal the active ingredients of EBN responsible for skin
G. Chan, Z. C. Wong, K. Lam, L. Cheng, L. M. Zhang, Huangquan Lin, T. Dong, K. Tsim   +7 more
semanticscholar   +1 more source

Chimerolectins: Classification, structural architecture, and functional perspectives

Protein Science, Volume 34, Issue 9, September 2025.
Abstract Lectins are proteins or glycoproteins capable of binding specifically and reversibly to carbohydrates, a property that, in itself, gives them great functional versatility in organisms from all kingdoms of nature. A subclass of these proteins, called chimerolectins, is composed of proteins that have at least one lectin domain associated with ...
Vanir Reis Pinto‐Junior, Benildo Sousa Cavada, Kyria Santiago Nascimento   +2 more
wiley   +1 more source

A Bifunctional Enzyme Catalyzes the First Two Steps in N-Acetylneuraminic Acid Biosynthesis of Rat Liver

Journal of Biological Chemistry, 1997
N-Acetylneuraminic acid (Neu5Ac) is the precursor of sialic acids, a group of important molecules in biological recognition systems. Biosynthesis of Neu5Ac is initiated and regulated by its key enzyme, UDP-N-acetylglucosamine 2-epimerase (UDP-GlcNAc 2 ...
Roger Stäsche, S. Hinderlich, C. Weise, Karin Effertz, L. Lucka, Petra Moormann, W. Reutter   +6 more
semanticscholar   +1 more source

Thyroxine-binding globulin: investigation of microheterogeneity [PDF]

, 1981
Preparations of T4-binding globulin (TBG) from human serum was performed using only two affinity chromatography steps. Purity of the protein was demonstrated by a single band in overloaded disc and sodium dodecyl sulfate electrophoresis, equimolar ...
Gärtner, Roland, Henze, R., Horn, K., Pickardt, C. R., Scriba, Peter Christian   +4 more
core   +1 more source

Glycosylation‐Dependent Stability of Human Pentraxin‐2 Revealed by Surface‐Induced Dissociation and Ion Mobility Mass Spectrometry

Angewandte Chemie International Edition, Volume 64, Issue 35, August 25, 2025.
The intricate glycosylation pattern of human Pentraxin‐2 (PTX‐2) poses a challenge in studying the structural impact of individual glycans. By combining surface‐induced dissociation (SID) or unfolding (SIU) with ion mobility mass spectrometry, we successfully differentiated the stability of glycoengineered PTX‐2 variants.
Philipp Bittner, Felix Kuhne, Adam Pruška, Julian A. Harrison, Natalie Preiss, Markus Haberger, Dietmar Reusch, Renato Zenobi   +7 more
wiley   +1 more source

N-Glycolylneuraminic Acid (Neu5Gc) Null Large Animals by Targeting the CMP-Neu5Gc Hydroxylase (CMAH)

Frontiers in Immunology, 2019
The two major sialic acids described in mammalian cells are the N-glycolylneuraminic acid (Neu5Gc) and the N-acetylneuraminic acid (Neu5Ac). Neu5Gc synthesis starts from the N-acetylneuraminic acid (Neu5Ac) precursor modified by an hydroxylic group ...
Andrea Perota, Cesare Galli, Cesare Galli   +2 more
doaj   +1 more source

A novel synthetic receptor-based immunoassay for influenza vaccine quantification. [PDF]

PLoS ONE, 2013
Vaccination is the most effective prophylactic method for preventing influenza. Quantification of influenza vaccine antigens is critically important before the vaccine is used for human immunization. Currently the vaccine antigen quantification relies on
Anwar M Hashem, Caroline Gravel, Aaron Farnsworth, Wei Zou, Michelle Lemieux, Kangwei Xu, Changgui Li, Junzhi Wang, Marie-France Goneau, Maria Merziotis, Runtao He, Michel Gilbert, Xuguang Li   +12 more
doaj   +1 more source

Sialic acid utilization by Cronobacter sakazakii [PDF]

, 2013
Background: The Cronobacter genus is composed of seven species, and can cause infections in all age groups. Of particular concern is C. sakazakii, as this species is strongly associated with severe and often fatal cases of necrotizing enterocolitis and ...
Forsythe, S, Hariri, S, Joseph, S, Masood, N   +3 more
core   +1 more source

Toward the Synthesis of 3,3‐Difluoro Deaminated Sialic Acid (C3DFKDN)

European Journal of Organic Chemistry, Volume 28, Issue 30, August 19, 2025.
The synthesis of protected C3‐difluoro KDN (C3DFKDN), an unnatural derivative of the sialic acid member, KDN, and key building block for KDN‐based chemical probes, is reported. Its 12‐step synthetic route starts from commercially available methyl d‐mannopyranoside and key steps include a Reformatsky reaction with ethyl bromodifluoroacetate, alkylation ...
Lemeng Chao, Tom Wennekes
wiley   +1 more source