Results 41 to 50 of about 809,751 (208)

An In Silico Functional Analysis of Non-Synonymous Single-Nucleotide Polymorphisms of Bovine CMAH Gene and Potential Implication in Pathogenesis

Pathogens, 2023
The sugar molecule N-glycolylneuraminic acid (Neu5Gc) is one of the most common sialic acids discovered in mammals. Cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) catalyses the conversion of N-acetylneuraminic acid (Neu5Ac) to Neu5Gc ...
Oluwamayowa Joshua Ogun, Opeyemi S. Soremekun, Georg Thaller, Doreen Becker   +3 more
doaj   +1 more source

Lipase-catalyzed acetylation of N-acetylneuraminic acid deiivative [PDF]

Bioorganic & Medicinal Chemistry Letters, 1999
A facile preparation of triacetylated derivative of 2-phenylthioglycoside of N-acetylneuraminic acid (4) was achieved by treatment with lipase PS in vinyl acetate. The major product 4 has a free hydroxyl group at C-7. Results of time-course HPLC analysis indicate that the reactivity of the hydroxyl groups under this condition is in the following order;
Lo, Lee-Chiang, Hsiao, Kwo-Feng, Ueng, Shau-Hua, Wu, Shi-Hsiung   +3 more
openaire   +3 more sources

Distinguishing N-acetylneuraminic acid linkage isomers on glycopeptides by ion mobility-mass spectrometry.

Chemical Communications, 2016
Differentiating the structure of isobaric glycopeptides represents a major challenge for mass spectrometry-based characterisation techniques. Here we show that the regiochemistry of the most common N-acetylneuraminic acid linkages of N-glycans can be ...
H. Hinneburg, Johanna Hofmann, Johanna Hofmann, W. B. Struwe, A. Thader, F. Altmann, D. V. Silva, P. Seeberger, P. Seeberger, K. Pagel, K. Pagel, D. Kolarich   +11 more
semanticscholar   +1 more source

(1R,2R,3S,4R)-1-(Acetylamino)-2,4,5-tris(acetyloxy)-1-((2S)-4-(benzyloxy)-5-oxo-2,5-dihydrofuran-2-yl)pentan-3-yl Acetate

Molbank, 2022
Treatment of N-acetylneuraminic acid with excess base in the presence of benzyl bromide gives a polyhydroxylated 1,4 lactone which after acetylation gave the title compound in 20% overall yield.
Liam S. Fitzgerald, Ciaran O’Malley, Paul V. Murphy   +2 more
doaj   +1 more source

Production of α1,3-galactosyltransferase and cytidine monophosphate-N-acetylneuraminic acid hydroxylase gene double-deficient pigs by CRISPR/Cas9 and handmade cloning

Journal of reproduction and development, 2016
Gene-knockout pigs hold great promise as a solution to the shortage of organs from donor animals for xenotransplantation. Several groups have generated gene-knockout pigs via clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR ...
Hanchao Gao, Chengjiang Zhao, Xi Xiang, Yong Li, Yanli Zhao, Zesong Li, D. Pan, Yifan Dai, H. Hara, D. Cooper, Z. Cai, Lisha Mou   +11 more
semanticscholar   +1 more source

Identification and Characterization of an In Silico Designed Membrane‐Active Peptide with Antiviral Properties

Advanced Science, EarlyView.
An evolutionary molecular dynamics platform is used to design P1.6, a membrane‐active peptide that senses lipid packing defects in viral envelopes. P1.6 adopts a stabilized α‐helical structure upon membrane contact, disrupts virus‐like liposomes, and damages HIV‐1 particles.
Pascal von Maltitz, Niek van Hilten, Tatjana Weil, Thunchanok Thummaraj, Jeroen Methorst, Dennis Aschmann, Alexander Kros, Clarissa Read, Jasmina Gačanin, Herre Jelger Risselada, Jan Münch   +10 more
wiley   +1 more source

Differential carbohydrate recognition by Campylobacter jejuni strain 11168: influences of temperature and growth conditions. [PDF]

PLoS ONE, 2009
The pathogenic clinical strain NCTC11168 was the first Campylobacter jejuni strain to be sequenced and has been a widely used laboratory model for studying C. jejuni pathogenesis. However, continuous passaging of C.
Christopher J Day, Joe Tiralongo, Regan D Hartnell, Carie-Anne Logue, Jennifer C Wilson, Mark von Itzstein, Victoria Korolik   +6 more
doaj   +1 more source

Determination of α-hydroxy acids in cosmetics by UHPLC-MS/MS

Shanghai yufang yixue
ObjectiveTo establish a UHPLC-MS/MS quantitative method for the determination of glucuronic acid， tartaric acid， glycolic acid， malic acid， lactic acid， citric acid， DL-2-hydroxybutyric acid sodium， mandelic acid， benzilic acid， hydroxycaprylic acid ...
RU Ge, XU Yong, HAN Jing, ZHANG Kai, PENG Xingsheng, ZHENG Rong   +5 more
doaj   +1 more source

N-Acetylneuraminic Acid (NANA) in Measles Virus

Experimental Biology and Medicine, 1978
The envelope glycoproteins and glycolipids of paramyxoviruses appear to be derived from the host cell plasma membrane during viral release (1, 2). Measles envelope glycoprotein spikes effect attachment of the virion to cell surfaces, thereby initiating either he-magglutination (HA) or infection (3,4).
P, Dore-Duffy, C, Howe
openaire   +2 more sources

The evolutionary landscape and serotypic dynamics of avian infectious bronchitis virus from spike protein

iMetaOmics, EarlyView.
This study integrates two decades of surveillance with genomic and structural analyses to decipher how spike protein glycosylation haplotypes drive avian coronavirus evolution. We uncover how specific glycosylation patterns associate with receptor‐binding affinity, shape global transmission dynamics, and correlate with clinical outcomes.
Hao Zhang, Zongxi Han, Chuangchao Zou, Yihui Huang, Shiping Sun, Ouyang Peng, Usama Ashraf, Qiuping Xu, Yao Ge, Qixiang Kang, Xiuli Ma, Xinheng Zhang, Ye Zhao, Xin Yang, Hongning Wang, Guozhong Zhang, Qingmei Xie, Mang Shi, Yongsen Ruan, Min Liao, Shengwang Liu, Yongchang Cao   +21 more
wiley   +1 more source