Results 41 to 50 of about 836,707 (292)

The effect of long-term moderate exercise on myocardial metabolome in rats

Chinese Journal of Physiology, 2023
Regular moderate physical exercise is beneficial for the cardiovascular system. Our prior study has demonstrated a long-term moderate exercise (4-week of 60-min 74.0% V̇O2max treadmill running) is optimal in protecting from exhaustive exercise-induced ...
Zheng Ping, Xiao Li Zhang, Zi Wen Wang, Xue Bin Cao   +3 more
doaj   +1 more source

Ferrets exclusively synthesize Neu5Ac and express naturally humanized influenza A virus receptors [PDF]

, 2014
Mammals express the sialic acids ​N-acetylneuraminic acid (​Neu5Ac) and ​N-glycolylneuraminic acid (​Neu5Gc) on cell surfaces, where they act as receptors for pathogens, including influenza A virus (IAV). ​Neu5Gc is synthesized from ​Neu5Ac by the enzyme
Böhm, Raphael, Coloe, Peter J., Grimmond, Sean M., Hartley-Tassell, Lauren E., Haselhorst, Thomas, Hawthorne, Paula L., Jennings, Michael P., Lukowski, Samuel W., Ng, Preston S.K., Paton, Adrienne W., Paton, James C., Steen, Jason A., Trezise, Ann E.O., von Itzstein, Mark, Wang, Hui   +14 more
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Dataset on inflammatory proteins expressions and sialic acid levels in apolipoprotein E-deficient mice with administration of N-acetylneuraminic acid and/or quercetin

Data in Brief, 2016
The data presented in this article describe an effect of N-acetylneuraminic acid and/or quercetin on the inflammatory proteins expressions (TNF-α, ICAM-1, VCAM-1 and MOMA-2) and the N-acetylneuraminic acid (NANA) levels of apolipoprotein E-deficient mice
Rongrong Dong, Fahui Li, Shucun Qin, Yi Wang, Yanhong Si, Xuelian Xu, Hua Tian, Lei Zhai, Guangjie Zhang, Yongjun Li, Yawei Zhou, Ying Zhang, Nan Zhang, Shoudong Guo   +13 more
doaj   +1 more source

Estimation of Salivary and Serum Total Sialic Acid Levels in Periodontal Health and Disease [PDF]

Journal of Clinical and Diagnostic Research, 2014
Background: Chronic gingivitis and periodontitis are inflammatory diseases. An important function of host sialic acid is to regulate innate immunity. The aim of the study was to assess the concentration of Total sialic acid (TSA) in saliva and serum ...
SUREKHA R RATHOD, FAROOQUE KHAN, ABHAY P KOLTE, MADHUR GUPTA   +3 more
doaj   +1 more source

N-Glycolylneuraminic Acid in Animal Models for Human Influenza A Virus

Viruses, 2021
The first step in influenza virus infection is the binding of hemagglutinin to sialic acid-containing glycans present on the cell surface. Over 50 different sialic acid modifications are known, of which N-acetylneuraminic acid (Neu5Ac) and N ...
Cindy M. Spruit, Nikoloz Nemanichvili, Masatoshi Okamatsu, Hiromu Takematsu, Geert-Jan Boons, Robert P. de Vries   +5 more
doaj   +1 more source

Neuraminidase Activity in \u3cem\u3eDiplococcus pneumoniae\u3c/em\u3e [PDF]

, 1966
Kelly, R. T. (Marquette University School of Medicine, Milwaukee, Wis.), D. Greiff, and S. Farmer. Neuraminidase activity in Diplococcus pneumoniae. J. Bacteriol. 91:601–603.
ADA G. L., FRENCH E. L., HUGHES R. C., KELLY R., D., LOWRY H., N., RAFELSON M. E., SCHNEIR M., R., WAL, WARREN L., WHITEHOUSE M. W.   +9 more
core   +2 more sources

Streptococcus pneumoniae NanC. Structural insights into the specificity and mechanism of a sialidase that produces a sialidase inhibitor [PDF]

, 2015
This work was supported by the Biotechnology and Biological Sciences Research Council (UK) and the Medical Research Council (UK).Streptococcus pneumoniae is an important human pathogen that causes a range of disease states.
Lukacik, Petra, Owen, C. David, Potter, Jane A., Sleator, Olivia, Taylor, Garry L., Walsh, Martin A.   +5 more
core   +1 more source

Synthesis of Sulfo-Sialic Acid Analogues: Potent Neuraminidase Inhibitors in Regards to Anomeric Functionality

Scientific Reports, 2017
The design, synthesis and application of N-acetylneuraminic acid-derived compounds bearing anomeric sulfo functional groups are described. These novel compounds, which we refer to as sulfo-sialic acid analogues, include 2-decarboxy-2-deoxy-2-sulfo-N ...
Christopher J. Vavricka, Chiaki Muto, Tomohisa Hasunuma, Yoshinobu Kimura, Michihiro Araki, Yan Wu, George F. Gao, Hiroshi Ohrui, Minoru Izumi, Hiromasa Kiyota   +9 more
doaj   +1 more source

Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site [PDF]

, 2018
Many pathogenic bacteria utilise sialic acids as an energy source or use them as an external coating to evade immune detection. As such, bacteria that colonise sialylated environments deploy specific transporters to mediate import of scavenged sialic ...
Abramson, J, Andersson, R, Beis, K, Bengtsson-Palme, J, Bisignano, P, Caing-Carlsson, R, Claesson, E, Dobson, RCJ, Dunevall, E, Farewell, A, Friemann, R, Goyal, P, Grabe, M, Indiveri, C, Nilsson, UJ, North, RA, Paz, A, Pochini, L, Ramaswamy, S, Scalise, M, Wahlgren, WY   +20 more
core   +3 more sources

Single-channel measurements of an N-acetylneuraminic acid-inducible outer membrane channel in Escherichia coli [PDF]

, 2012
NanC is an Escherichia coli outer membrane protein involved in sialic acid (Neu5Ac, i.e., N-acetylneuraminic acid) uptake. Expression of the NanC gene is induced and controlled by Neu5Ac. The transport mechanism of Neu5Ac is not known.
Eisenberg, Bob, Giri, Janhavi, Peneff, Caroline M., Tang, John M., Wirth, Christophe   +4 more
core   +1 more source