Results 51 to 60 of about 13,352,036 (198)

Serum N-Glycan Profiling Predicts Prognosis in Patients Undergoing Hemodialysis

The Scientific World Journal, 2013
Background. The aim of this study is to evaluate the usefulness of serum N-glycan profiling for prognosis in hemodialysis patients. Methods. Serum N-glycan analysis was performed in 100 hemodialysis patients in June 2008 using the glycoblotting method ...
Shingo Hatakeyama, Maho Amano, Yuki Tobisawa, Tohru Yoneyama, Megumi Tsushima, Kazuko Hirose, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Hisao Saitoh, Kanemitsu Yamaya, Tomihisa Funyu, Shin-Ichiro Nishimura, Chikara Ohyama   +13 more
doaj   +1 more source

Rapid chemical de-N-glycosylation and derivatization for liquid chromatography of immunoglobulin N-linked glycans. [PDF]

PLoS ONE, 2018
Glycan analysis may result in exploitation of glycan biomarkers and evaluation of heterogeneity of glycosylation of biopharmaceuticals. For N-linked glycan analysis, we investigated alkaline hydrolysis of the asparagine glycosyl carboxamide of ...
Akihiko Kameyama, Santha Kumara Dissanayake, Wai Wai Thet Tin   +2 more
doaj   +1 more source

Regulation of Glycan Structures in Murine Embryonic Stem Cells

Journal of Biological Chemistry, 2012
Background: Glycans contribute to vertebrate development, but regulatory mechanisms are unknown. Results: Glycans and transcripts encoding the glycosylation machinery were profiled during stem cell differentiation.
A. Nairn, K. Aoki, Mitche dela Rosa, Mindy Porterfield, Jae-Min Lim, M. Kulik, J. Michael Pierce, L. Wells, S. Dalton, M. Tiemeyer, K. Moremen   +10 more
semanticscholar   +1 more source

The Glycan Shield of HIV Is Predominantly Oligomannose Independently of Production System or Viral Clade

PLoS ONE, 2011
The N-linked oligomannose glycans of HIV gp120 are a target for both microbicide and vaccine design. The extent of cross-clade conservation of HIV oligomannose glycans is therefore a critical consideration for the development of HIV prophylaxes.
Camille Bonomelli, Katherine Doores, Katherine Doores, D. Dunlop, Victoria E. Thaney, R. Dwek, D. Burton, D. Burton, M. Crispin, Christopher N. Scanlan   +9 more
semanticscholar   +1 more source

Combining functional metagenomics and glycoanalytics to identify enzymes that facilitate structural characterization of sulfated N-glycans

Microbial Cell Factories, 2021
Background Sulfate modification of N-glycans is important for several biological functions such as clearance of pituitary hormones or immunoregulation.
Léa Chuzel, Samantha L. Fossa, Madison L. Boisvert, Samanta Cajic, René Hennig, Mehul B. Ganatra, Udo Reichl, Erdmann Rapp, Christopher H. Taron   +8 more
doaj   +1 more source

Role of N-Glycosylation in FcγRIIIa interaction with IgG

Frontiers in Immunology, 2022
Immunoglobulins G (IgG) and their Fc gamma receptors (FcγRs) play important roles in our immune system. The conserved N-glycan in the Fc region of IgG1 impacts interaction of IgG with FcγRs and the resulting effector functions, which has led to the ...
Julie Van Coillie, Julie Van Coillie, Julie Van Coillie, Morten A. Schulz, Arthur E. H. Bentlage, Arthur E. H. Bentlage, Noortje de Haan, Zilu Ye, Dionne M. Geerdes, Wim J. E. van Esch, Lise Hafkenscheid, Rebecca L. Miller, Yoshiki Narimatsu, Yoshiki Narimatsu, Sergey Y. Vakhrushev, Zhang Yang, Zhang Yang, Gestur Vidarsson, Gestur Vidarsson, Henrik Clausen   +19 more
doaj   +1 more source

Mutations in four glycosyl hydrolases reveal a highly coordinated pathway for rhodopsin biosynthesis and N-glycan trimming in Drosophila melanogaster. [PDF]

PLoS Genetics, 2014
As newly synthesized glycoproteins move through the secretory pathway, the asparagine-linked glycan (N-glycan) undergoes extensive modifications involving the sequential removal and addition of sugar residues.
Erica E Rosenbaum, Eva Vasiljevic, Kimberley S Brehm, Nansi Jo Colley   +3 more
doaj   +1 more source

Simple capillary electrophoresis-mass spectrometry method for complex glycan analysis using a flow-through microvial interface.

Analytical Chemistry, 2014
A flow-through microvial is used to interface capillary electrophoresis and mass spectrometry (CE-MS) to develop a method for simultaneous profiling both neutral and sialylated glycans without derivatization or labeling.
R. Jayo, M. Thaysen‐Andersen, P. Lindenburg, R. Haselberg, T. Hankemeier, R. Ramautar, D. Chen   +6 more
semanticscholar   +1 more source

The Association Between Normal BMI With Central Adiposity And Proinflammatory Potential Immunoglobulin G N-Glycosylation

Diabetes, Metabolic Syndrome and Obesity, 2019
Di Liu,1,* Qihuan Li,1,2,* Jing Dong,3 Dong Li,4 Xizhu Xu,4 Weijia Xing,4 Xiaoyu Zhang,1 Weijie Cao,1 Haifeng Hou,4 Hao Wang,1,5 Manshu Song,1 Lixin Tao,1 Xiaoping Kang,6 Qun Meng,1 Wei Wang,1,4,5 Xiuhua Guo,1 Youxin Wang1 1Beijing Key Laboratory of ...
Liu D, Li Q, Dong J, Li D, Xu X, Xing W, Zhang X, Cao W, Hou H, Wang H, Song M, Tao L, Kang X, Meng Q, Wang W, Guo X, Wang Y   +16 more
doaj  

Non-targeted N-glycome profiling reveals multiple layers of organ-specific diversity in mice

Nature Communications
N-glycosylation is one of the most common protein modifications in eukaryotes, with immense importance at the molecular, cellular, and organismal level.
Johannes Helm, Stefan Mereiter, Tiago Oliveira, Anna Gattinger, David M. Markovitz, Josef M. Penninger, Friedrich Altmann, Johannes Stadlmann   +7 more
doaj   +1 more source