Results 111 to 120 of about 4,874 (195)

Loss of N-glycolylneuraminic acid in humans: Mechanisms, consequences, and implications for hominid evolution [PDF]

American Journal of Physical Anthropology, 2001
The surface of all mammalian cells is covered with a dense and complex array of sugar chains, which are frequently terminated by members of a family of molecules called sialic acids. One particular sialic acid called N-glycolylneuraminic acid (Neu5Gc) is widely expressed on most mammalian tissues, but is not easily detectable on human cells.
openaire   +3 more sources

The Sodium Sialic Acid Symporter From Staphylococcus aureus Has Altered Substrate Specificity

Frontiers in Chemistry, 2018
Mammalian cell surfaces are decorated with complex glycoconjugates that terminate with negatively charged sialic acids. Commensal and pathogenic bacteria can use host-derived sialic acids for a competitive advantage, but require a functional sialic acid ...
Rachel A. North, Rachel A. North, Rachel A. North, Weixiao Y. Wahlgren, Weixiao Y. Wahlgren, Daniela M. Remus, Daniela M. Remus, Mariafrancesca Scalise, Sarah A. Kessans, Sarah A. Kessans, Elin Dunevall, Elin Claesson, Tatiana P. Soares da Costa, Matthew A. Perugini, S. Ramaswamy, Jane R. Allison, Jane R. Allison, Jane R. Allison, Cesare Indiveri, Rosmarie Friemann, Rosmarie Friemann, Renwick C. J. Dobson, Renwick C. J. Dobson   +22 more
doaj   +1 more source

Loss of a newly discovered microRNA in Chinese hamster ovary cells leads to upregulation of N-glycolylneuraminic acid sialylation on monoclonal antibodies. [PDF]

Biotechnol Bioeng, 2022
Fischer S, Mathias S, Stadermann A, Yang S, Schmieder V, Zeh N, Schmidt N, Richter P, Wright S, Zimmermann E, Ley Y, van der Meer J, Hartsch T, Bernloehr C, Otte K, Bradl H, Gamer M, Schulz P.   +17 more
europepmc   +1 more source

Inactivation of the CMAH gene and deficiency of Neu5Gc play a role in human brain evolution

Inflammation and Regeneration
During human evolution, some genes were lost or silenced from the genome of hominins. These missing genes might be the key to the evolution of humans’ unique cognitive skills. An inactivation mutation in CMP-N-acetylneuraminic acid hydroxylase (CMAH) was
Yuxin Liu, Jinhong Li, Qicai Liu
doaj   +1 more source

Loss of N-Glycolylneuraminic Acid in Human Evolution [PDF]

Journal of Biological Chemistry, 2000
Els C.M. Brinkman-Van der Linden, Eric R. Sjoberg, Lekh Raj Juneja, Paul R. Crocker, Nissi Varki, Ajit Varki   +5 more
openaire   +1 more source

Serum Antibodies to N-Glycolylneuraminic Acid Are Elevated in Duchenne Muscular Dystrophy and Correlate with Increased Disease Pathology in Cmah^-/-mdx Mice. [PDF]

Am J Pathol, 2021
Martin PT, Kawanishi K, Ashbrook A, Golden B, Samraj A, Crowe KE, Zygmunt DA, Okerblom J, Yu H, Maki A, Diaz S, Chen X, Janssen PML, Varki A.   +13 more
europepmc   +1 more source

N-Glycolylneuraminic Acid Binding of Avian and Equine H7 Influenza A Viruses. [PDF]

J Virol, 2022
Spruit CM, Zhu X, Tomris I, Ríos-Carrasco M, Han AX, Broszeit F, van der Woude R, Bouwman KM, Luu MMT, Matsuno K, Sakoda Y, Russell CA, Wilson IA, Boons GJ, de Vries RP.   +14 more
europepmc   +1 more source

Editorial: Human Antibodies Against the Dietary Non-human Neu5Gc-Carrying Glycans in Normal and Pathologic States

Frontiers in Immunology, 2020
Jean-Paul Soulillou, Jean-Paul Soulillou, Vered Padler-Karavani   +2 more
doaj   +1 more source

Absorption and Transport Mechanism of Red Meat-Derived N-glycolylneuraminic Acid and Its Damage to Intestinal Barrier Function through the NF-κB Signaling Pathway. [PDF]

Toxins (Basel), 2023
He E, Quan W, Luo J, Liu C, Zheng W, Shen Q.   +5 more
europepmc   +1 more source

Effect of Factor H on Complement Alternative Pathway Activation in Human Serum Remains on Porcine Cells Lacking N-Glycolylneuraminic Acid. [PDF]

Front Immunol, 2022
Lee H, Park EM, Ko N, Choi K, Oh KB, Kang HJ.   +5 more
europepmc   +1 more source