Results 161 to 170 of about 4,874 (195)
Some of the next articles are maybe not open access.
N-glycolylneuraminic acid deficiency in humans
Biochimie, 2001Classic studies suggested that the common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc) is an oncofetal antigen in humans, being immunogenic in adult humans and yet apparently expressed in human fetuses and tumors. We and others have recently found that the human deficiency of Neu5Gc can be explained by an inactivating mutation in the gene ...
openaire +2 more sources
Neu5Gc (N-Glycolylneuraminic Acid)
2020Among a group of SAs, NeuAc and NeuGc are two of the most common derivatives. SA biosynthesis begins at the cytosol and the synthesized SA is converted to activated nucleotide saccharide form in the nucleus. The activated SA is delivered to Golgi apparatus for ST reaction. STs add SA residues to the terminal sugars of the glycolipids, especially of the
openaire +1 more source
ChemInform Abstract: Microwave‐Assisted Synthesis of N‐Glycolylneuraminic Acid Derivatives.
ChemInform, 2014AbstractA rapid, efficient, and scalable synthesis of the title compounds is achieved from the natural N‐acetyl precursors via sequential microwave‐assisted N‐deacetylation and further N‐glycolylation, e.g. synthesis of compound (IV).
Pradeep Chopra +4 more
openaire +1 more source
Neuraminic Acids/Sialic Acids (N-acetyl- and N-glycolylneuraminic Acid)
2020Currently, the three domains in life include eukaryote, archaea, and bacteria to organize life as representatives. Archaea and bacteria consist of organisms having prokaryotic cells or prokaryotes. Domain eukaryote includes kingdom plantae, kingdom fungi, kingdom animalia, and protists. Only protists include multiple kingdoms.
openaire +1 more source
Archives of Biochemistry and Biophysics, 1992
We generated two murine monoclonal antibodies (MAbs) specific for mono- and disialylgangliosides having N-glycolylneuraminic acid (NeuGc) as their sialic acid moiety, respectively, by immunizing C3H/HeN mice with these purified gangliosides adsorbed to Salmonella minnesota followed by fusion with mouse myeloma cells.
H, Ozawa, I, Kawashima, T, Tai
openaire +2 more sources
We generated two murine monoclonal antibodies (MAbs) specific for mono- and disialylgangliosides having N-glycolylneuraminic acid (NeuGc) as their sialic acid moiety, respectively, by immunizing C3H/HeN mice with these purified gangliosides adsorbed to Salmonella minnesota followed by fusion with mouse myeloma cells.
H, Ozawa, I, Kawashima, T, Tai
openaire +2 more sources
The serum dependence of the occurrence of N-glycolylneuraminic acid in HeLa cells
Biochimica et Biophysica Acta (BBA) - General Subjects, 1973Abstract The occurrence of N -glycolylneuraminic acid in HeLa cells is shown to be due to the calf serum added to the growth medium, and not to their cancerous nature. When Hela cells are grown with human serum as supplement, only N -acetylneuraminic acid can be found. The ganglioside composition of these cells is also reported.
L, Hof, H, Faillard
openaire +2 more sources
Xenotransplantation, 2004
Abstract: Background: N‐glycolylneuraminic acid (NeuGc) epitopes, so called Hanganutziu–Deicher (HD) antigens, which are widely expressed on endothelial cells of all mammals except humans, are considered to be potential targets for natural and elicited anti‐nonGalα1‐3 Gal (Gal) antibodies in humans.
Yuko, Miwa +7 more
openaire +2 more sources
Abstract: Background: N‐glycolylneuraminic acid (NeuGc) epitopes, so called Hanganutziu–Deicher (HD) antigens, which are widely expressed on endothelial cells of all mammals except humans, are considered to be potential targets for natural and elicited anti‐nonGalα1‐3 Gal (Gal) antibodies in humans.
Yuko, Miwa +7 more
openaire +2 more sources
Nephron, 1996
Recombinant human erythropoietin (rHUEPO) was produced by Chinese hamster ovary cells and commercially distributed to hospitals by two pharmaceutical companies in Japan ('ESPO' by Kirin Brewery Co. Ltd., and Sankyo Co. Ltd., and 'EPOGIN' by Chugai Pharmaceutical Co.
Noguchi, A +3 more
openaire +2 more sources
Recombinant human erythropoietin (rHUEPO) was produced by Chinese hamster ovary cells and commercially distributed to hospitals by two pharmaceutical companies in Japan ('ESPO' by Kirin Brewery Co. Ltd., and Sankyo Co. Ltd., and 'EPOGIN' by Chugai Pharmaceutical Co.
Noguchi, A +3 more
openaire +2 more sources
An expeditious route to N-glycolylneuraminic acid based on enzyme-catalyzed reaction
Tetrahedron, 1997Abstract A new preparative way of N -glycolylneuraminic acid (NeuGc), one of the important family of sialic acids, from N -acetylglucosamine (GlcNAc) via N -acetylmannosamine (ManNAc) was established based on the combination of chemical and enzymatic reactions. In a kinetic study of the key enzymatic reaction for this process, aldolase-catalyzed
Atsuhito Kuboki +3 more
openaire +1 more source
Carbohydrate Research, 1997
A novel GM3 O-acetylated at C-4 and at C-9 of N-glycolylneuraminic acid (4,9-di-O-Ac GM3), together with a second GM3 O-acetylated at O-4 of the neuraminic acid and O-6 of D-galactose (4,6'-di-O-Ac GM3) were isolated from equine erythrocytes as a mixture in approximate 1:1 ratio. These two major species were chromatographically inseparable.
Y, Yachida, K, Tsuchihashi, S, Gasa
openaire +2 more sources
A novel GM3 O-acetylated at C-4 and at C-9 of N-glycolylneuraminic acid (4,9-di-O-Ac GM3), together with a second GM3 O-acetylated at O-4 of the neuraminic acid and O-6 of D-galactose (4,6'-di-O-Ac GM3) were isolated from equine erythrocytes as a mixture in approximate 1:1 ratio. These two major species were chromatographically inseparable.
Y, Yachida, K, Tsuchihashi, S, Gasa
openaire +2 more sources