Synthesis of N-Glycolylneuraminic Acid (Neu5Gc) and Its Glycosides [PDF]
Frontiers in Immunology, 2019 Sialic acids constitute a family of negatively charged structurally diverse monosaccharides that are commonly presented on the termini of glycans in higher animals and some microorganisms.
Anoopjit Singh Kooner, Hai Yu, Xi Chen
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N-Glycolylneuraminic Acid (Neu5Gc) Null Large Animals by Targeting the CMP-Neu5Gc Hydroxylase (CMAH) [PDF]
Frontiers in Immunology, 2019 The two major sialic acids described in mammalian cells are the N-glycolylneuraminic acid (Neu5Gc) and the N-acetylneuraminic acid (Neu5Ac). Neu5Gc synthesis starts from the N-acetylneuraminic acid (Neu5Ac) precursor modified by an hydroxylic group ...
Andrea Perota +2 more
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The Structural Complexity and Animal Tissue Distribution of N-Glycolylneuraminic Acid (Neu5Gc)-Terminated Glycans. Implications for Their Immunogenicity in Clinical Xenografting [PDF]
Frontiers in Molecular Biosciences, 2019 N-Glycolylneuraminic acid (Neu5Gc)-terminated glycans are present in all animal cells/tissues that are already used in the clinic such as bioprosthetic heart valves (BHV) as well as in those that potentially will be xenografted in the future to overcome ...
Michael E. Breimer, Jan Holgersson
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A comparative study of N-glycolylneuraminic acid (Neu5Gc) and cytotoxic T cell (CT) carbohydrate expression in normal and dystrophin-deficient dog and human skeletal muscle. [PDF]
PLoS ONE, 2014 The expression of N-glycolylneuraminic acid (Neu5Gc) and the cytotoxic T cell (CT) carbohydrate can impact the severity of muscular dystrophy arising from the loss of dystrophin in mdx mice.
Paul T Martin +8 more
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Sensitive and specific detection of the non-human sialic Acid N-glycolylneuraminic acid in human tissues and biotherapeutic products. [PDF]
PLoS ONE, 2009 BackgroundHumans are genetically defective in synthesizing the common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc), but can metabolically incorporate it from dietary sources (particularly red meat and milk) into glycoproteins and glycolipids ...
Sandra L Diaz +8 more
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The Role of Non-Human Sialic Acid Neu5Gc-Containing Glycoconjugates in Human Tumors: A Review of Clinical and Experimental Evidence [PDF]
BiomoleculesN-Glycolylneuraminic acid (Neu5Gc) is a sialic acid variant commonly found in most mammals but not synthesized by humans due to an inactivating mutation in the CMP-Neu5Ac hydroxylase (CMAH) gene. Despite this, Neu5Gc-containing molecules are consistently
Rancés Blanco, Juan P. Muñoz
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A systematic review reveals conflicting evidence for the prevalence of antibodies against the sialic acid ‘xenoautoantigen’ Neu5Gc in humans and the need for a standardised approach to quantification [PDF]
Frontiers in Molecular BiosciencesDespite an array of hypothesised implications for health, disease, and therapeutic development, antibodies against the non-human sialic acid N-glycolylneuraminic acid (Neu5Gc) remain a subject of much debate.
Esme Hutton +5 more
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N-Glycolylneuraminic Acid in Animal Models for Human Influenza A Virus
Viruses, 2021 The first step in influenza virus infection is the binding of hemagglutinin to sialic acid-containing glycans present on the cell surface. Over 50 different sialic acid modifications are known, of which N-acetylneuraminic acid (Neu5Ac) and N ...
Cindy M. Spruit +5 more
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Detection of the Dietary xenoglycan N-glycolylneuraminic Acid (Neu5Gc) and anti-Neu5Gc Antibodies within Reproductive Tracts of Male and Female Infertility Subjects [PDF]
Clinical Obstetrics, Gynecology and Reproductive Medicine, 2015 Objective: To assess the frequency of dietary xenoglycanNeu5Gc and antibodies in males and females and its impact on fertility. Design: Prospective study of semen, uterine lavage, and follicular fluid from subjects undergoing infertility evaluation or in
J. Sroga +10 more
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Tetrahedron Letters, 2021 Abstract Efficient synthesis of lauryl thioglycoside of Neu5Gc was accomplished from a known thioglycoside of Neu5Ac. The reactivities of the Neu5Gc thioglycoside for O-glycosidation by means of TMSOTf-NIS as a promoter system were investigated, and the thioglycoside showed good activities with simple alcohols. In addition to the simple alcohols, the
Jianhong Zhang +4 more
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