Results 11 to 20 of about 3,818 (198)

Aberrant N-glycolylneuraminic acid in breast MCF-7 cancer cells and cancer stem cells

Frontiers in Molecular Biosciences, 2022
N-Glycolylneuraminic acid (Neu5Gc) is not normally detected in humans because humans lack the hydroxylase enzyme that converts cytidine-5′-monophosphate-N-acetylneuraminic acid (CMP-Neu5Ac) to CMP-Neu5Gc; thus, any Neu5Gc appearing in the human body is ...
Wenqian Yang, Yuan Jiang, Qulian Guo, Zhixin Tian, Zhigang Cheng   +4 more
doaj   +2 more sources

Absence of Neu5Gc and Presence of Anti-Neu5Gc Antibodies in Humans—An Evolutionary Perspective [PDF]

Frontiers in Immunology, 2019
The glycocalyx of human cells differs from that of many other mammals by the lack of the sialic acid N-glycolylneuraminic acid (Neu5Gc) and increased abundance of its precursor N-acetylneuraminic acid (Neu5Ac).
Meghan O. Altman, Pascal Gagneux, Pascal Gagneux   +2 more
doaj   +4 more sources

Serological Assessment of Alpha Galactosidase, N-Glycolylneuraminic Acid, and Histopathological Observations in Xenograft Recipients. [PDF]

Cureus
Background and aims The galactose-α-1,3-galactose (αGal) epitope and the associated anti-Gal antibodies, along with the non-human sialic acid N-glycolylneuraminic acid (Neu5Gc) and its corresponding anti-Neu5Gc antibodies, represent critical obstacles in
Ramesh B, Ramanan S, Srimurugan B, Fakoya AO.   +3 more
europepmc   +2 more sources

Absorption and Transport Mechanism of Red Meat-Derived N-glycolylneuraminic Acid and Its Damage to Intestinal Barrier Function through the NF-κB Signaling Pathway

Toxins, 2023
N-glycolylneuraminic acid (Neu5Gc) is a specific factor in red meat that induces intestinal disease. Our aim was to investigate the effect of Neu5Gc on the intestinal barrier as well as its mechanism of endocytosis and exocytosis. Ten specific inhibitors
Enqi He, Wei Quan, Jie Luo, Chuxin Liu, Wanting Zheng, Qingwu Shen   +5 more
doaj   +2 more sources

Aptamer-CRISPR/Cas12a-Based Lateral Flow Technique for Visualized Rapid Detection of Endogenous Damage Factor Neu5Gc in Red Meat [PDF]

Foods
The N-glycolylneuraminic acid (Neu5Gc), a major salivary acid molecule found on the cell surface of animals such as pigs, cows, and sheep, can be metabolically incorporated into the body through consumption of animal-derived foods like red meat.
Yuxi Guo, Honglin Ren, Han Wang, Xuepeng Duan, Shuaihao Qi, Xi Yang, Chunyi Shangguan, Haosong Li, Yansong Li, Pan Hu, Qiang Lu, Shiying Lu   +11 more
doaj   +2 more sources

Glycosylated Biotherapeutics: Immunological Effects of N-Glycolylneuraminic Acid

Frontiers in Immunology, 2020
The emerging field of biotherapeutics provides successful treatments for various diseases, yet immunogenicity and limited efficacy remain major concerns for many products.
Sharon Yehuda, Vered Padler-Karavani
doaj   +2 more sources

N-glycolylneuraminic acid serum biomarker levels are elevated in breast cancer patients at all stages of disease

BMC Cancer, 2022
Background Normal human tissues do not express glycans terminating with the sialic acid N-glycolylneuraminic acid (Neu5Gc), yet Neu5Gc-containing glycans have been consistently found in human tumor tissues, cells and secretions and have been proposed as ...
Lucy K. Shewell, Christopher J. Day, Jamie R. Kutasovic, Jodie L. Abrahams, Jing Wang, Jessica Poole, Colleen Niland, Kaltin Ferguson, Jodi M. Saunus, Sunil R. Lakhani, Mark von Itzstein, James C. Paton, Adrienne W. Paton, Michael P. Jennings   +13 more
doaj   +2 more sources

Variability of Sialic Acids in Beef Breeds and Nutritional Implications in Red Meat [PDF]

Molecules
This study examines the variability of sialic acids, specifically N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc), in beef from seven cattle breeds (Holstein Friesian, Red Pied, Maremmana, Chianina, Charolais, Limousin, and ...
Michela Contò, Maria Miarelli, Sabrina Di Giovanni, Sebastiana Failla   +3 more
doaj   +2 more sources

Species-specific N-glycan patterns in animal and human breast milk samples [PDF]

Frontiers in Nutrition
The main components of milk are protein, fat and carbohydrates. Glycans are complex carbohydrate structures covalently bound to proteins and lipids or exist freely in solutions.
Davide Ret, Davide Ret, Salvatore Alessio Gentile, Johanna Rohrhofer, Larissa Koidl, Francesca Cozzi, Eva Untersmayr   +6 more
doaj   +2 more sources

Inactivation of the CMAH gene and deficiency of Neu5Gc play a role in human brain evolution [PDF]

Inflammation and Regeneration
During human evolution, some genes were lost or silenced from the genome of hominins. These missing genes might be the key to the evolution of humans’ unique cognitive skills. An inactivation mutation in CMP-N-acetylneuraminic acid hydroxylase (CMAH) was
Yuxin Liu, Jinhong Li, Qicai Liu
doaj   +2 more sources