Results 31 to 40 of about 3,818 (198)
An Overview of the Importance and Value of Porcine Species in Sialic Acid Research
Biology, 2022 Humans frequently interact with pigs, whose meat is also one of the primary sources of animal protein. They are one of the main species at the center of sialic acid (Sia) research.
Oluwamayowa Joshua Ogun +2 more
doaj +1 more source
Preferential Accumulation of 14C-N-Glycolylneuraminic Acid over 14C-N-Acetylneuraminic Acid in the Rat Brain after Tail Vein Injection. [PDF]
PLoS ONE, 2015 The two main molecular species of sialic acid existing in nature are N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc). Neu5Ac is abundant in mammalian brains and plays crucial roles in many neural functions.
Risa Taguchi +6 more
doaj +1 more source
Pathogens, 2023 Porcine meat is the most consumed red meat worldwide. Pigs are also vital tools in biological and medical research. However, xenoreactivity between porcine’s N-glycolylneuraminic acid (Neu5Gc) and human anti-Neu5Gc antibodies poses a significant ...
Oluwamayowa Joshua Ogun +2 more
doaj +1 more source
N-glycolyl chondroitin synthesis using metabolically engineered E. coli
AMB Express, 2020 N-glycolyl chondroitin (Gc-CN) is a metabolite of N -glycolylneuraminic acid (Neu5Gc), a sialic acid that is commonly found in mammals, but not humans. Humans can incorporate exogenous Neu5Gc into their tissues from eating red meat.
Adeola E. Awofiranye +7 more
doaj +1 more source
Complex Issues of Cardiovascular Diseases, 2023 HighlightsStabilization of bovine pericardial tissue by ethylene glycol diglycidyl ether does not remove the N-glycolylneuraminic acid contained in its structure, which is one of the most immunoreactive glycan xenoantigens;N-glycolylneuraminic acid can ...
A. Kostyunin +5 more
semanticscholar +1 more source
Xenotransplantation, 2022 Antibody‐mediated rejection has long been known to be one of the major organ failure mechanisms in xenotransplantation. In addition to the porcine α1,3‐galactose (α1,3Gal) epitope, N‐Glycolylneuraminic acid (Neu5Gc), a sialic acid, has been identified as
Ryan Chaban +17 more
semanticscholar +1 more source
Ferrets exclusively synthesize Neu5Ac and express naturally humanized influenza A virus receptors [PDF]
, 2014 Mammals express the sialic acids N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc) on cell surfaces, where they act as receptors for pathogens, including influenza A virus (IAV). Neu5Gc is synthesized from Neu5Ac by the enzyme
Böhm, Raphael +14 more
core +1 more source
Lipid rafts and human diseases: why we need to target gangliosides
FEBS Open Bio, Volume 13, Issue 9, Page 1636-1650, September 2023., 2023 Membrane gangliosides are involved in many diseases, often through a modification of lipid raft homeostasis due to the binding of a pathological protein. Thus, these diseases should be considered as membrane disorders. This article develops the ‘ganglioside‐targeting therapy’ concept for treating such diseases with innovative molecules capable of ...
Jacques Fantini
wiley +1 more source
Membrane-enclosed multienzyme (MEME) synthesis of 2,7-anhydro-sialic acid derivatives [PDF]
, 2017 Naturally occurring 2,7-anhydro-alpha-N-acetylneuraminic acid (2,7-anhydro-Neu5Ac) is a transglycosylation product of bacterial intramolecular trans-sialidases (IT-sialidases).
Andrew Bell +41 more
core +2 more sources
Erythrocytes from GGTA1/CMAH knockout pigs: implications for xenotransfusion and testing in non-human primates [PDF]
, 2014 Background Pig erythrocytes are potentially useful to solve the worldwide shortage of human blood for transfusion. Domestic pig erythrocytes, however, express antigens that are bound by human preformed antibodies.
Burlak, Christopher +6 more
core +1 more source