Results 161 to 170 of about 4,267 (193)

Pseudorabies virus infection reshapes the host epitranscriptome by globally suppressing but selectively elevating specific RNA modifications. [PDF]

Front Microbiol
Wang Y, Wang Q, Zhong J, Mao F, Liu X, Meng F, Chen X.   +6 more
europepmc   +1 more source

A reference-guided iterative approach to polish the nanopore sequencing basecalling for therapeutic RNA quality control. [PDF]

Commun Biol
Wang Z, Tu MJ, Liu Z, Wang KK, Fang Y, Hao N, Zhang HH, Que J, Sun X, Yu AM, Ding H.   +10 more
europepmc   +1 more source

Effects of N⁶-Methyladenosine (m⁶A) and 5-Methylcytosine (m⁵C) Modifications in the Guide Region of CRISPR RNA on Cas12a Nuclease Activity. [PDF]

Bioconjug Chem
Pandit B, Hanson E, Dagci H, Yang Q, Yigit MV, Royzen M.   +5 more
europepmc   +1 more source

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Molecular Characteristics of N1-Methyladenosine Regulators and Their Correlation with Overall Cancer Survival

DNA and Cell Biology, 2021
N1-methyladenosine (m1A) is a prevalent RNA modification widely affecting RNA structural stability, folding, and interactions with proteins. Recently, there have been increasing reports on the roles of m1A regulators in tumors. However, their mechanisms and clinical relevance remain unclear.
Juan, Li, Chunting, Zhang, Xin, Yuan, Yuan, Cao   +3 more
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N1-methyladenosine methylome in messenger RNA and non-coding RNA

Current Opinion in Chemical Biology, 2018
Chemical modifications to rRNA, tRNA and mRNA provide a new regulatory layer of gene expression, which is termed as the `epitranscriptome'. N1-methyladenosine (m1A), first characterized more than 50 years ago, is a well-known modification in rRNA and tRNA.
Xushen, Xiong, Xiaoyu, Li, Chengqi, Yi
openaire   +2 more sources

Abstract 1713: TRMT6-mediated N1-methyladenosine methylation promotes tumorigenesis in colorectal cancer

Cancer Research, 2023
Abstract Background: N1-methyladenosine (m1A) within tRNAs, an essential and highly conserved RNA modification, has recently emerged as a significant epigenetic modification that plays a pivotal role in tumor progression in some cancers. However, the role of m1A methylation in colorectal cancer (CRC) remains largely unexplored.
SILEI SUI, CAIMING XU, Ying Qing, Hideo Baba, Ajay Goel   +4 more
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The Secret Life of N1-methyladenosine: A Review on its Regulatory Functions

Journal of Molecular Biology
N1-methyladenosine (m1A) is a conserved modification on house-keeping RNAs, including tRNAs and rRNAs. With recent advancement on m1A detection and mapping, m1A is revealed to have a secret life with regulatory functions. This includes the regulation of its canonical substrate tRNAs, and expands into new territories such as tRNA fragments, mRNAs and ...
Nhi Yen Tran, Nguyen, Xisheng, Liu, Anindya, Dutta, Zhangli, Su   +3 more
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Precise quantification of N1-Methyladenosine with a site-specific RNase H cleavage-assisted isothermal amplification strategy

Sensors and Actuators B: Chemical, 2022
Abstract Specific and accurate determination of N1-Methyladenosine (m1A) is of critical significance to better understand its biological functions. Precise quantification of low level of RNA modification against a high background of homologous normal RNA still remains a big challenge.
Yuanyuan Sun, Fangfang Sun, Bingjie Han, Chenghui Liu   +3 more
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Small Molecule‐Inducible and Photoactivatable Cellular RNA N1‐Methyladenosine Editing

Angewandte Chemie
AbstractN1‐methyladenosine (m1A) modification is one of the most prevalent epigenetic modifications on RNA. Given the vital role of m1A modification in RNA processing such as splicing, stability and translation, developing a precise and controllable m1A editing tool is pivotal for in‐depth investigating the biological functions of m1A.
Guoyou Xie, Yunqing Lu, Jiaxin He, Xianyuan Yang, Jiawang Zhou, Cheng Yi, Jian Li, Zigang Li, Gholamreza Asadikaram, Hongxin Niu, Xiaofeng Xiong, Jiexin Li, Hongsheng Wang   +12 more
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[Selective characterisation of N1-methyladenosine and N7-methylguanosine in urine (author's transl)].

Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie, 1981
We describe the selective analysis of N-methylated ribonucleosides, i.e., N1-methyl adenosine (m1Ado) and N7-methyl guanosine (m7Guo) in the presence of other nucleosides in urine. m1Ado as well as m7Guo were characterized by use of chromatographic techniques including substance specific chemical reactions.
E, Schlimme, K S, Boos, M, Weise
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