Results 101 to 110 of about 46,645 (191)

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Synthesis of DNA Building Blocks With Aminonaphthalimides and Cyanovinylenes as Uncharged Fluorophores: Fluorescent Readout From Turn‐On to Red‐Shift

European Journal of Organic Chemistry, EarlyView.
DNA architectures with aminonaphthalimides and cyanovinylenes as base surrogates form interstrand and intrastrand dimers showed that can be used as nucleic acid‐sensitive probes by their fluorescence turn‐on and red‐shift as readouts. The fluorescence turn‐on was tested by probing N6‐methyl‐2’‐deoxyadenosine (m6A) in DNA.
Jan Kunzmann, Anna‐Lena Ruopp, Hans‐Achim Wagenknecht   +2 more
wiley   +1 more source

Table_1_Identification of N6-Methyladenosine-Related lncRNAs as a Prognostic Signature in Glioma.docx

, 2022
N6-methyladenosine (m6A) modification is the most abundant modification in long noncoding RNAs (lncRNAs). Current studies have shown that the abnormal expression of m6A-related genes is closely associated with the tumorigenesis and progression of glioma.
Shenglun Li (11976044), Weihai Ning (7540880), Yujia Chen (844413), Yuduo Guo (9638345), Lixin Ma (18620), Jiacheng Xu (3629917), Hongwei Zhang (28335), Xiang Wang (127867), Mingshan Zhang (6956762), Yanming Qu (11976047)   +9 more
core   +1 more source

Nanopore direct RNA sequencing and the epitranscriptome: Advances in mapping native RNA landscapes

iMeta, EarlyView.
Nanopore direct RNA sequencing advances transcriptomics by capturing full‐length transcripts and multiple RNA modifications; this review details its principles, workflows, tools, applications, challenges, and future research potential. Abstract Nanopore direct RNA sequencing (DRS) has transformed transcriptomics by enabling single‐molecule, long‐read ...
Tianyuan Zhang, Jia Li, Chao Tang, You Wu, Hao Wu, Xi‐Tong Zhu, Ziyang Luo, Hang Qin, Lishan Ding, Yu Zeng, Shiou Yih Lee, Xiaotao Shen, Shiwen Gao, Zhaoyang Tian, Qian Tang, Mian Li, Muhammad Tahir Ul Qamar, Yang Dong, Komivi Dossa, Yaxuan Zhang, Hu Chen, Sanqi An, Xiang Yu, Lu Chen, Dingjie Wang, Shengli Li, Ling‐Ling Chen, Yanqiang Li   +27 more
wiley   +1 more source

Image_4_Identification of N6-Methyladenosine-Related lncRNAs as a Prognostic Signature in Glioma.tif

, 2022
N6-methyladenosine (m6A) modification is the most abundant modification in long noncoding RNAs (lncRNAs). Current studies have shown that the abnormal expression of m6A-related genes is closely associated with the tumorigenesis and progression of glioma.
Shenglun Li (11976044), Weihai Ning (7540880), Yujia Chen (844413), Yuduo Guo (9638345), Lixin Ma (18620), Jiacheng Xu (3629917), Hongwei Zhang (28335), Xiang Wang (127867), Mingshan Zhang (6956762), Yanming Qu (11976047)   +9 more
core   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Image_1_Identification of N6-Methyladenosine-Related lncRNAs as a Prognostic Signature in Glioma.tif

, 2022
N6-methyladenosine (m6A) modification is the most abundant modification in long noncoding RNAs (lncRNAs). Current studies have shown that the abnormal expression of m6A-related genes is closely associated with the tumorigenesis and progression of glioma.
Shenglun Li (11976044), Weihai Ning (7540880), Yujia Chen (844413), Yuduo Guo (9638345), Lixin Ma (18620), Jiacheng Xu (3629917), Hongwei Zhang (28335), Xiang Wang (127867), Mingshan Zhang (6956762), Yanming Qu (11976047)   +9 more
core   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy, Dávid Mező, Kinga K. Nagy, Viktória Perey‐Simon, Judit Tóth, Angéla Békési, Beáta Vértessy, Máté Varga   +7 more
wiley   +1 more source

N6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis [PDF]

, 2019
Circular RNAs (circRNAs) have been implicated in cancer progression through largely unknown mechanisms. Herein, we identify an N6-methyladenosine (m6A) modified circRNA, circNSUN2, frequently upregulated in tumor tissues and serum samples from colorectal
Judde, JG, Guan, X, Ma, XD, Han, K, Deas, O, Xu, RH, Pan, ZZ, Chen, X, Wang, F, Ma, NF, Xia, LP, Zhang, JX, Yun, JP, Chen, RX, Xie, D, Chen, JW, Wang, FW   +16 more
core   +1 more source