Lysine l‐Lactylation: Bridging Metabolism, Chromatin and Disease
Enzymatic regulation of KL‐la. The enzymatic regulation of KL‐la involves two distinct pathways for L‐lactate accumulation: intracellular production through glycolysis‐derived pyruvate conversion by lactate dehydrogenase (LDH) or direct cellular uptake via monocarboxylate transporters (MCTs). These L‐lactate pools fuel two distinct lactylation pathways—
Anoosha Malik +10 more
wiley +1 more source
Epitranscriptomic Stability-Variable Extents of N1-Methyladenosine to N6-Methyladenosine Conversion Under Different Experimental Conditions. [PDF]
Shnaider FM, Kanan H, Patel S, Chiu NHL.
europepmc +1 more source
Beyond Sequence: Posttranslational Remodeling of Antigens in Autoimmunity
ABSTRACT Autoimmune responses are often attributed to failed tolerance to self‐proteins, yet protein expression alone cannot explain why certain antigens dominate disease, why autoreactivity emerges under stress, or why specific HLA alleles shape risk.
Cynthiya Shrestha +2 more
wiley +1 more source
Profiles and roles of N6-methyladenosine modification in bovine oocyte maturation. [PDF]
Han T +9 more
europepmc +1 more source
Eine Universelle Nukleosid‐zu‐Nukleosid‐5′‐triphosphat‐Enzymkaskade angetrieben durch Polyphosphat
Nukleosid‐5′‐Triphosphate (NTPs) sind wichtige Bausteine für Nukleinsäuren. Ihre chemische Synthese ist aufgrund der geringen Ausbeute der 5′‐Triphosphorylierungsreaktion nur wenig effizient. Wir stellen hier eine universelle, durch Polyphosphat angetriebene Zwei‐Enzym‐Kaskade vor, die eine direkte Phosphorylierung von Nukleosiden zu NTPs ermöglicht ...
Jonathan P. Suess +1 more
wiley +1 more source
N6-methyladenosine modification in the context of viral infection: from molecular mechanism to therapeutic potential. [PDF]
Wu X, Deng Z, Li Y, Shi C.
europepmc +1 more source
Correction: Interferon-stimulated gene 20 (ISG20) selectively degrades N6-methyladenosine modified Hepatitis B Virus transcripts. [PDF]
Imam H +4 more
europepmc +1 more source
HNRM: hyperedge neighborhood-based representation for predicting N6-methyladenosine-related regulatory pathways. [PDF]
Jiang D, Li Y, Yu L.
europepmc +1 more source
Immunometabolic reprogramming in rheumatoid arthritis: the epitranscriptomic role of N6-methyladenosine in innate and adaptive immunity. [PDF]
Yang J, Wan L, Chen H, Li S, Zhou Y.
europepmc +1 more source
Dynamic modulation of N6-methyladenosine by ionizing radiation in human cells. [PDF]
Cruz-Garcia L +6 more
europepmc +1 more source

