Results 131 to 140 of about 21,268 (171)

METTL14‐Mediated m6A Methylation Preserves Cardiomyocyte Homeostasis and Attenuates Progeria‐Associated Cardiac Remodeling

Aging Cell, Volume 25, Issue 10, October 2026.
Progerin accumulation downregulates the expression of m6A methyltransferases METTL3 and METTL14 in cardiac tissues, impairing m6A modification‐mediated regulation of target genes including Casq2, Ifna and Ifnb, leading to calcium signaling dysregulation and pro‐inflammatory activation in the aged heart.
Shixiao Wang, Jie Zhang, Ying Ao, Dan Rao, Cong Yu, Chenzhong Xu, Ming Wang, Mingying Li, Xin Huang, Jianfei Zhang, Rui Mei, Zhen Zhang, Jie Sun, Juanli Duan, Ying Sun, Zimei Wang, Wen Su, Baohua Liu   +17 more
wiley   +1 more source

The N6-Methyladenosine-Modified CIT Promotes Uterine Corpus Endometrial Carcinoma Progression by Inhibiting the Hippo Signaling Pathway. [PDF]

Immunol Cell Biol
Tong Y, Xu L, Sun Y, Zhang K, Fu X.
europepmc   +1 more source

Tumor‐Derived Exosomal piR‐hsa‐28212 Promotes Lymphatic Metastasis in Breast Cancer

Cancer Science, Volume 117, Issue 10, Page 2733-2751, October 2026.
Breast cancer–derived exosomal piR‐hsa‐28212 promotes lymphangiogenesis and lymph node metastasis by activating VEGFC/VEGFR3 signaling. It stabilizes TBX1 mRNA in lymphatic endothelial cells and METTL3 protein in tumor cells, enhancing VEGFR3 expression and VEGFC secretion.
Yafen Wang, Tianli Zhang, Xue Kong, Yao Tong, Yanru Li, Xiangjun Dong, Chuanxin Wang, Juan Li   +7 more
wiley   +1 more source

Lactylation and N6-Methyladenosine RNA modification in neuropsychiatric sequelae after intracerebral hemorrhage: a hypothesis-generating metabolic-glial-circuit framework. [PDF]

Mol Biol Rep
Chen W, Teng H, Yang X, Gao F, Han C, Yang S, Zhou H, Yang Z.   +7 more
europepmc   +1 more source

N6‐Methyladenosine Demethylase FTO Protects Pancreatic ΒTC6 Cells From Cholesterol‐Triggered Damage by Regulating Nfatc4: Insights From RNA‐Seq Analysis

Chemical Biology &Drug Design, Volume 108, Issue 4, October 2026.
FTO Protects Mouse Pancreatic Beta‐TC‐6 cells From Cholesterol‐Triggered Damage by Repressing Nfatc4. ABSTRACT Excessive cholesterol contributes to pancreatic β‐cell dysfunction and plays a critical role in the pathogenesis of metabolic disorders.
Pingping Hong, Yongjie Li, Jiandong Lin, Lingxiao Wang, Xiaofang Fan, Hongfang Wang, Luping Lou   +6 more
wiley   +1 more source

Role and prognostic value of N6-methyladenosine RNA modification regulators in glycolytic reprogramming during sepsis. [PDF]

J Intensive Care
Liu X, Zhang Y, Feng L, Xiang A, Kang Z, Zhang Q, Kang L.   +6 more
europepmc   +1 more source

Polyphenism Through RNA Chemical Modifications

Molecular Ecology, Volume 35, Issue 19, October 2026.
ABSTRACT Polyphenism, the capacity of a single genotype to produce discrete phenotypes in response to environmental cues, has long served as a model for understanding developmental plasticity. While classical studies have highlighted hormonal signalling and transcription‐factor‐driven gene regulatory networks that mediate these environmentally induced ...
Ralf Schneider, Ehsan Pashay Ahi
wiley   +1 more source

Circulating N6-methyladenosine RNA as a diagnostic and a stage-associated prognostic biomarker in colorectal cancer. [PDF]

BMC Cancer
Lin YT, Chang AC, Chien CS, Lin CC, Lan HY, Teng HW, Hwang WL.   +6 more
europepmc   +1 more source

A DRACH Observed/Expected Metric Reveals the Evolutionary Landscape of Epitranscriptomic Regulation Across Bilateria

Annals of the New York Academy of Sciences, Volume 1564, Issue 1, October 2026.
Epitranscriptomic marks are highly variable across life stages and tissues, complicating comparisons between species. Using m6A consensus motifs, we developed a genomic indicator reflecting transcript methylability, the DRACH o/e score, that we used to investigate epitranscriptomic features and associated functions across nine bilaterian species.
Natacha Clairet, Jérémy Le Luyer, Hélène Auger, Maximilian Haeussler, Guillaume Rivière   +4 more
wiley   +1 more source

Epitranscriptomic Stability-Variable Extents of N1-Methyladenosine to N6-Methyladenosine Conversion Under Different Experimental Conditions. [PDF]

Biomolecules
Shnaider FM, Kanan H, Patel S, Chiu NHL.
europepmc   +1 more source