NADK Governs Ferroptosis Susceptibility by Orchestrating NADPH Homeostasis [PDF]
AntioxidantsFerroptosis, a regulated cell death pathway driven by iron-dependent lipid peroxidation, is modulated by cellular antioxidant systems, particularly the glutathione (GSH)–glutathione peroxidase 4 (GPX4) axis.
Xinyi Chen +10 more
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NADK-mediated de novo NADP(H) synthesis is a metabolic adaptation essential for breast cancer metastasis [PDF]
Redox Biology, 2023 Metabolic reprogramming and metabolic plasticity allow cancer cells to fine-tune their metabolism and adapt to the ever-changing environments of the metastatic cascade, for which lipid metabolism and oxidative stress are of particular importance.
Didem Ilter +11 more
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NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma [PDF]
Cell Reports, 2021 Summary: Metabolic adaptations and the signaling events that control them promote the survival of pancreatic ductal adenocarcinoma (PDAC) at the fibrotic tumor site, overcoming stresses associated with nutrient and oxygen deprivation.
Tanya Schild +10 more
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Genome-wide analysis of the NADK gene family in plants. [PDF]
PLoS ONE, 2014 BACKGROUND: NAD(H) kinase (NADK) is the key enzyme that catalyzes de novo synthesis of NADP(H) from NAD(H) for NADP(H)-based metabolic pathways. In plants, NADKs form functional subfamilies. Studies of these families in Arabidopsis thaliana indicate that
Wen-Yan Li +4 more
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Molecular properties and regulation of NAD+ kinase (NADK)
Redox Biology, 2023 Nicotinamide adenine dinucleotide (NAD+) kinase (NADK) phosphorylates NAD+, thereby producing nicotinamide adenine dinucleotide phosphate (NADP). Both NADK genes and the NADP(H)-producing mechanism are evolutionarily conserved among archaea, bacteria ...
Shin-ichi Oka +3 more
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Calmodulin Is the Fundamental Regulator of NADK-Mediated NAD Signaling in Plants [PDF]
Frontiers in Plant Science, 2019 Calcium (Ca2+) signaling and nicotinamide adenine dinucleotide (NAD) signaling are two basic signal regulation pathways in organisms, playing crucial roles in signal transduction, energy metabolism, stress tolerance, and various developmental processes ...
Li Tai +9 more
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NADK as a molecular marker to distinguish between alcohol- and non-alcohol-associated liver cirrhosis: A pilot study [PDF]
Clinical & Experimental HepatologyWe investigated whether nicotinamide adenine dinucleotide kinase (NADK) expression is selectively diminished in alcohol-associated liver cirrhosis (AC), and evaluated its potential as a biomarker for this condition.Human liver samples were obtained during liver transplantation or resection procedures at Kosin University Gospel Hospital and classified ...
Ki-Hoon Park +8 more
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Genes and DiseasesNicotinamide adenine dinucleotide (NAD+) kinase (NADK) phosphorylates NAD+ to generate NADP+, which plays a crucial role in maintaining NAD+/NADP+ homeostasis, cellular redox balance, and metabolism. However, how human NADK activity is regulated, and how
Mengxue Hu +6 more
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Episodic evolution of a eukaryotic NADK repertoire of ancient provenance.
PLoS ONE, 2019 NAD kinase (NADK) is the sole enzyme that phosphorylates nicotinamide adenine dinucleotide (NAD+/NADH) into NADP+/NADPH, which provides the chemical reducing power in anabolic (biosynthetic) pathways.
Oliver Vickman, Albert Erives
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NFATc1-mediated activation of the pentose phosphate pathway and cell cycle dysregulation collectively drive tumor progression [PDF]
OncogenesisThe pentose phosphate pathway (PPP) supplies abundant reducing equivalents and biosynthetic precursors to support the rapid proliferation of tumor cells. An increased PPP flux is a hallmark of metabolic reprogramming in tumors. Although nuclear factor of
Suyang Zhang +8 more
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