Results 31 to 40 of about 2,008 (163)

Deciphering the functional landscape of phosphosites with deep neural network

Cell Reports, 2023
Summary: Current biochemical approaches have only identified the most well-characterized kinases for a tiny fraction of the phosphoproteome, and the functional assignments of phosphosites are almost negligible. Herein, we analyze the substrate preference
Zhongjie Liang, Tonghai Liu, Qi Li, Guangyu Zhang, Bei Zhang, Xikun Du, Jingqiu Liu, Zhifeng Chen, Hong Ding, Guang Hu, Hao Lin, Fei Zhu, Cheng Luo   +12 more
doaj   +1 more source

The Ca2+-CaM Signaling Pathway Mediates Potassium Uptake by Regulating Reactive Oxygen Species Homeostasis in Tobacco Roots Under Low-K+ Stress

Frontiers in Plant Science, 2021
Potassium (K+) deficiency severely threatens crop growth and productivity. Calcium (Ca2+) signaling and its sensors play a central role in the response to low-K+ stress. Calmodulin (CaM) is an important Ca2+ sensor.
Yingfeng Wang, Xiaoyan Dai, Gaoqiang Xu, Zhuoyi Dai, Peiyu Chen, Tongjin Zhang, Huifen Zhang   +6 more
doaj   +1 more source

Conferring the ability to utilize inorganic polyphosphate on ATP-specific NAD kinase [PDF]

, 2013
ATP特異性の獲得メカニズムの解明 : 新薬と新しい物質生産系の開発に期待. 京都大学プレスリリース. 2013-09-11.NAD kinase (NADK) is a crucial enzyme for production of NADP(+). ATP-specific NADK prefers ATP to inorganic polyphosphate [poly(P)] as a phosphoryl donor, whereas poly(P)/ATP-NADK utilizes ...
Kawai, Shigeyuki, Murata, Kousaku, Nakamichi, Yusuke, Yoshioka, Aya   +3 more
core   +1 more source

Separating NADH and NADPH fluorescence in live cells and tissues using FLIM [PDF]

, 2014
NAD is a key determinant of cellular energy metabolism. In contrast, its phosphorylated form, NADP, plays a central role in biosynthetic pathways and antioxidant defence.
Bain, Angus J., Blacker, Thomas S., Duchen, Michael R., Gale, Jonathan E., Mann, Zoe F., Szabadkai, Gyorgy, Ziegler, Mathias   +6 more
core   +3 more sources

Multiplex protein profiling of bronchial aspirates reveals disease-, mortality- and respiratory sequelae-associated signatures in critically ill patients with ARDS secondary to SARS-CoV-2 infection

Frontiers in Immunology, 2022
IntroductionBronchial aspirates (BAS) obtained during invasive mechanical ventilation (IMV) constitutes a useful tool for molecular phenotyping and decision making.AimTo identify the proteomic determinants associated with disease pathogenesis, all-cause ...
Marta Molinero, Marta Molinero, Silvia Gómez, Silvia Gómez, Iván D. Benítez, Iván D. Benítez, J. J. Vengoechea, J. J. Vengoechea, Jessica González, Jessica González, Dinora Polanco, Clara Gort-Paniello, Clara Gort-Paniello, Anna Moncusí-Moix, Anna Moncusí-Moix, María C. García-Hidalgo, María C. García-Hidalgo, Manel Perez-Pons, Manel Perez-Pons, Thalía Belmonte, Thalía Belmonte, Gerard Torres, Gerard Torres, Jesús Caballero, Carme Barberà, Jose Ignacio Ayestarán Rota, Lorenzo Socías Crespí, Adrián Ceccato, Laia Fernández-Barat, Laia Fernández-Barat, Ricard Ferrer, Ricard Ferrer, Dario Garcia-Gasulla, Jose Ángel Lorente-Balanza, Jose Ángel Lorente-Balanza, Rosario Menéndez, Rosario Menéndez, Ana Motos, Ana Motos, Oscar Peñuelas, Oscar Peñuelas, Jordi Riera, Jordi Riera, Antoni Torres, Antoni Torres, Ferran Barbé, Ferran Barbé, David de Gonzalo-Calvo, David de Gonzalo-Calvo   +48 more
doaj   +1 more source

The Pseudogenes of Barley [PDF]

, 2017
Pseudogenes have a reputation of being ‘evolutionary relics’ or ‘junk DNA’. While they are well characterized in mammals, studies in more complex plant genomes were so far hampered by the absence of reference genome sequences.
Altschul, Balakirev, Benson, Bolot, Brenchley, Brosius, Cordaux, Dong, Dongen, Enright, Esnault, Falcon, Fu, Gaut, Gorbunova, Gorbunova, Haynes, Heslop-Harrison, Ho-Huu, Kaessmann, Kent, Kondrashov, Krzywinski, Larkin, Li, Mandal, Mascher, Pavlicek, Pink, Podlaha, Poliseno, Poliseno, Poovaiah, Roberts, Rocha, Sen, Sisu, Spannagl, Supek, Thibaud-Nissen, Thorvaldsdóttir, Torii, Tran, Tutar, Vihinen, Wang, Weiss-Schneeweiss, Wicker, Wicker, Xiao, Yang, Yu, Zhang, Zou   +53 more
core   +2 more sources

Mitochondrial NAD kinase in health and disease

Redox Biology, 2023
Nicotinamide adenine dinucleotide phosphate (NADP), a co-enzyme and an electron carrier, plays crucial roles in numerous biological functions, including cellular metabolism and antioxidation.
Ren Zhang, Kezhong Zhang
doaj   +1 more source

Analysis of nicotinate mononucleotide adenylyltransferase mutants and [PDF]

, 2005
BACKGROUND: Adenylation of nicotinate mononucleotide to nicotinate adenine dinucleotide is the penultimate step in NAD+ synthesis. In Escherichia coli, the enzyme nicotinate mononucleotide adenylyltransferase is encoded by the nadD gene.
Stancek, M, Schnell, R,, Rydén-Aulin, M
core   +1 more source

Fractionation of Hydrogen Isotopes by Sulfate- and Nitrate-Reducing Bacteria. [PDF]

, 2016
Hydrogen atoms from water and food are incorporated into biomass during cellular metabolism and biosynthesis, fractionating the isotopes of hydrogen-protium and deuterium-that are recorded in biomolecules.
Dawson, Katherine S, Fogel, Marilyn L, Osburn, Magdalena R, Sessions, Alex L   +3 more
core   +5 more sources

Cloning, Expression and Characterization of NAD Kinase from Staphylococcus aureus Involved in the Formation of NADP (H): A Key Molecule in the Maintaining of Redox Status and Biofilm Formation

Advanced Biomedical Research, 2017
Background:Staphylococcus aureus has the ability to form biofilms on any niches, a key pathogenic factor of this organism and this phenomenon is directly related to the concentration of NADPH.
U Venkateswara Prasad, D Vasu, R Rishi Gowtham, Krishna Pradeep, V Swarupa, S Yeswanth, Abhijit Choudhary, P. V. G. K. Sarma   +7 more
doaj   +1 more source