Results 31 to 40 of about 2,049 (165)

NADK is Activated by Oncogenic KRAS Signaling to Sustain Pancreatic Ductal Adenocarcinoma

SSRN Electronic Journal, 2020
Metabolic adaptations and the signaling events that control them have been implicated in the adaptation of pancreatic ductal adenocarcinoma (PDAC) to survive stresses associated with nutrient and oxygen deprivation at the tumor site. Recently, rewiring of NADPH production has been shown to play a key role in this process.
Tanya Schild, Melanie R. McReynolds, Christie Shea, Vivien Low, John M. Asara, Noah Dephoure, Joshua D. Rabinowitz, Ana P. Gomes, John Blenis   +8 more
openalex   +2 more sources

NAD kinase promotes Staphylococcus aureus pathogenesis by supporting production of virulence factors and protective enzymes

eLife, 2022
Nicotinamide adenine dinucleotide phosphate (NADPH) is the primary electron donor for reductive reactions that are essential for the biosynthesis of major cell components in all organisms.
Clarisse Leseigneur, Laurent Boucontet, Magalie Duchateau, Javier Pizarro-Cerda, Mariette Matondo, Emma Colucci-Guyon, Olivier Dussurget   +6 more
doaj   +1 more source

Supplementary Data from NUAK1-Mediated Phosphorylation of NADK Mitigates ROS Accumulation to Promote Osimertinib Resistance in Non–Small Cell Lung Carcinoma

<p>Supplementary information</p>
Wei Lin, Na Wang, Shihao Wu, Yongde Liao, Quanfu Huang, Kuo Li, Peiyuan Mei, Xiaojun Wang, Yongde Liao, Yunchong Meng   +9 more
  +4 more sources

Palmitoylation-dependent activation of NADK promotes NADP ⁺ synthesis and tumorigenesis [PDF]

Abstract NAD kinase (NADK) is the sole cytosolic enzyme that catalyzes the synthesis of nicotinamide adenine dinucleotide phosphate (NADP+) from NAD+. NADP+ is essential for anabolic reactions and redox balance. Here, we show that palmitate facilitates NADP+ synthesis by enhancing NADK palmitoylation and activity.
Luojun Chen, Wanjun Zhang, Yue Zhu, Xiaoke Xing, Yao Yi, Huadong Pei, Yali Chen, Weijie Qin, Pingfeng Zhang   +8 more
openalex   +2 more sources

Function of Pseudomonas fluorescens L5.1-96 proteins MPPE and NADK in wheat root colonization

Journal of Student Research
Pseudomonas fluorescens strain L5.1-96 is exceptional at colonizing wheat roots and resisting desiccation, both characteristics valuable to combatting Take-All disease, a devastating wheat root disease caused by the fungal pathogen Gaeumannomyces graminis var. triciti that drastically decreases wheat crop yield in the state of Washington.
Jumei Zhang, S. Álvares
openalex   +3 more sources

Data from NUAK1-Mediated Phosphorylation of NADK Mitigates ROS Accumulation to Promote Osimertinib Resistance in Non–Small Cell Lung Carcinoma

<div>Abstract<p>Osimertinib, a third generation epidermal growth factor receptor tyrosine kinase inhibitor, is approved as a first-line therapy in patients with advanced non–small cell lung carcinoma (NSCLC) with EGFR-activating mutations or the T790M resistance mutation.
Wei Lin, Na Wang, Shihao Wu, Yongde Liao, Quanfu Huang, Kuo Li, Peiyuan Mei, Xiaojun Wang, Yongde Liao, Yunchong Meng   +9 more
openalex   +2 more sources

Abstract 2261 Cytosolic NADK is conditionally essential for folate-dependent nucleotide synthesis in human cells

Journal of Biological Chemistry
Kyle M. Flickinger, Carlos Mellado Fritz, Kimberly S. Huggler, Gina Wade, Gavin Chang, Judith Simcox, Jason R. Cantor   +6 more
openalex   +3 more sources

Deciphering the functional landscape of phosphosites with deep neural network

Cell Reports, 2023
Summary: Current biochemical approaches have only identified the most well-characterized kinases for a tiny fraction of the phosphoproteome, and the functional assignments of phosphosites are almost negligible. Herein, we analyze the substrate preference
Zhongjie Liang, Tonghai Liu, Qi Li, Guangyu Zhang, Bei Zhang, Xikun Du, Jingqiu Liu, Zhifeng Chen, Hong Ding, Guang Hu, Hao Lin, Fei Zhu, Cheng Luo   +12 more
doaj   +1 more source

The Ca2+-CaM Signaling Pathway Mediates Potassium Uptake by Regulating Reactive Oxygen Species Homeostasis in Tobacco Roots Under Low-K+ Stress

Frontiers in Plant Science, 2021
Potassium (K+) deficiency severely threatens crop growth and productivity. Calcium (Ca2+) signaling and its sensors play a central role in the response to low-K+ stress. Calmodulin (CaM) is an important Ca2+ sensor.
Yingfeng Wang, Xiaoyan Dai, Gaoqiang Xu, Zhuoyi Dai, Peiyu Chen, Tongjin Zhang, Huifen Zhang   +6 more
doaj   +1 more source

Conferring the ability to utilize inorganic polyphosphate on ATP-specific NAD kinase [PDF]

, 2013
ATP特異性の獲得メカニズムの解明 : 新薬と新しい物質生産系の開発に期待. 京都大学プレスリリース. 2013-09-11.NAD kinase (NADK) is a crucial enzyme for production of NADP(+). ATP-specific NADK prefers ATP to inorganic polyphosphate [poly(P)] as a phosphoryl donor, whereas poly(P)/ATP-NADK utilizes ...
Kawai, Shigeyuki, Murata, Kousaku, Nakamichi, Yusuke, Yoshioka, Aya   +3 more
core   +1 more source