Results 41 to 50 of about 2,008 (163)

Distinct dual roles of p-Tyr42 RhoA GTPase in tau phosphorylation and ATP citrate lyase activation upon different Aβ concentrations

Redox Biology, 2020
Both the accumulation of Amyloid-β (Aβ) in plaques and phosphorylation of Tau protein (p-Tau) in neurofibrillary tangles have been identified as two major symptomatic features of Alzheimer's disease (AD).
Kim Cuong Cap, Yeon-Joo Jung, Bo Young Choi, Seung Jae Hyeon, Jae-Gyu Kim, Jung-Ki Min, Rokibul Islam, Abu Jubayer Hossain, Won-Suk Chung, Sang Won Suh, Hoon Ryu, Jae-Bong Park   +11 more
doaj   +1 more source

One-pot biosynthesis of 7β-hydroxyandrost-4-ene-3,17-dione from phytosterols by cofactor regeneration system in engineered mycolicibacterium neoaurum

Microbial Cell Factories, 2022
Background 7β-hydroxylated steroids (7β-OHSt) possess significant activities in anti-inflammatory and neuroprotection, and some of them have been widely used in clinics.
Yun-Qiu Zhao, Yong-Jun Liu, Wei-Ting Ji, Kun Liu, Bei Gao, Xin-Yi Tao, Ming Zhao, Feng-Qing Wang, Dong-Zhi Wei   +8 more
doaj   +1 more source

Distal Tumors Elicit Distinctive Gene Expression Changes in Mouse Brain, Different from Those Induced by Arthritis [PDF]

, 2009
Background: Tumor progression is characterized by high mutation rates, each mutation potentially generating an “alarm” signal. The brain is the main integrator of signals arising in the periphery from changes in homeostasis.
Alvarez, Mariano J., Pitossi, Fernando Juan, Podhajcer, Osvaldo Luis, Rubinstein, Marcelo, Salibe, Mariano C., Stolovitzky, Gustavo   +5 more
core   +1 more source

Microarray analysis of autoimmune diseases by machine learning procedures [PDF]

, 2009
—Microarray-based global gene expression profiling, with the use of sophisticated statistical algorithms is providing new insights into the pathogenesis of autoimmune diseases.
Armañanzas Arnedillo, Ruben, Bernales, Irantzu, Calvo Molinos, Borja, Fullaondo, Asier, Inza Cano, Iñaki, Larrañaga Múgica, Pedro, López Hoyos, Marcos, Martinez Taboada, Víctor, Ucar, Eduardo, Zubiaga, Ana María   +9 more
core   +2 more sources

Glucose-6-phosphate dehydrogenase contributes to the regulation of glucose uptake in skeletal muscle [PDF]

, 2016
The development of skeletal muscle insulin resistance is an early physiological defect, yet the intracellular mechanisms accounting for this metabolic defect remained unresolved. Here, we have examined the role of glucose-6-phosphate dehydrogenase (G6PDH)
Bruce, CR, Colgan, TD, Drummond, GR, Febbraio, MA, Greenfield, JR, Gregorevic, P, Henstridge, DC, Hoffman, NJ, Hong, YH, Iliades, P, Kingwell, BA, Kraakman, MJ, Lee-Young, RS, Lynch, GS, McConell, Glenn, Murphy, KT, Samocha-Bonet, D, Siebel, AL, Zivanovic, B   +18 more
core   +8 more sources

The two PPX-GppA homologues from Mycobacterium tuberculosis have distinct biochemical activities [PDF]

, 2012
Inorganic polyphosphate (poly-P), guanosine pentaphosphate (pppGpp) and guanosine tetraphosphate (ppGpp) are ubiquitous in bacteria. These molecules play a variety of important physiological roles associated with stress resistance, persistence, and ...
Chen, Wy, Choi, MY, Huang, JD, Lu, Bt, Tanner, JA, Wang, Y, Watt, RM, Wong, LLY   +7 more
core   +1 more source

Functional identification and subcellular localization of NAD kinase in the protozoan parasite Giardia intestinalis

Revista Colombiana de Química, 2019
Nicotinamide adenine dinucleotide phosphate (NADP) is an essential biomolecule that participates in the redox homeostasis and synthesis of signaling compounds. NAD kinase (NADK) (EC 2.7.1.23/2.7.1.86) is the only enzyme capable of synthesizing NADP. This
Laura Marcela Jutinico Shubach, Luis Ernesto Contreras Rodríguez, Javier Eduardo García Castañeda, María Helena Ramírez Hernández   +3 more
doaj   +1 more source

The NAD kinase OsNADK1 affects the intracellular redox balance and enhances the tolerance of rice to drought

BMC Plant Biology, 2020
Background NAD kinases (NADKs) are the only known enzymes that directly phosphorylate NAD(H) to generate NADP(H) in different subcellular compartments. They participate in multiple life activities, such as modulating the NADP/NAD ratio, maintaining the ...
Xiang Wang, Bin-Bin Li, Tian-Tian Ma, Liang-Yu Sun, Li Tai, Chun-Hong Hu, Wen-Ting Liu, Wen-Qiang Li, Kun-Ming Chen   +8 more
doaj   +1 more source

Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step [PDF]

, 2014
Aerobic glycolysis or the Warburg Effect (WE) is characterized by the increased metabolism of glucose to lactate. It remains unknown what quantitative changes to the activity of metabolism are necessary and sufficient for this phenotype.
Albeck, John G, Cluntun, Ahmad A, Huang, Lei, Hung, Yin P, Kim, Dongsung, Le, Anne, Liu, Xiaojing, Locasale, Jason W, Ser, Zheng, Shestov, Alexander A, Yellen, Gary   +10 more
core   +2 more sources

Exploring NAD(+) metabolism in host-pathogen interactions [PDF]

, 2016
Nicotinamide adenine dinucleotide (NAD+) is a vital molecule found in all living cells. NAD+ intracellular levels are dictated by its synthesis, using the de novo and/or salvage pathway, and through its catabolic use as co-enzyme or co-substrate.
Belinha, Ana, Gaifem, Joana, Mesquita, Inês Morais, Silvestre, Ricardo Jorge Leal   +3 more
core   +1 more source