Results 51 to 60 of about 2,049 (165)

One-pot biosynthesis of 7β-hydroxyandrost-4-ene-3,17-dione from phytosterols by cofactor regeneration system in engineered mycolicibacterium neoaurum

Microbial Cell Factories, 2022
Background 7β-hydroxylated steroids (7β-OHSt) possess significant activities in anti-inflammatory and neuroprotection, and some of them have been widely used in clinics.
Yun-Qiu Zhao, Yong-Jun Liu, Wei-Ting Ji, Kun Liu, Bei Gao, Xin-Yi Tao, Ming Zhao, Feng-Qing Wang, Dong-Zhi Wei   +8 more
doaj   +1 more source

Serum Proteomic and Metabolomic Signatures of High Versus Low Physical Function in Octogenarians. [PDF]

Aging Cell
Circulating factors are strongly implicated in modulating biological aging. In this study we show that the serum proteomic and metabolomic profile of high functioning octogenarians suggests lower activation of SASP, preservation of the tryptophan‐kynurenic pathway, higher lipophosphatidyl cholines promoting mitochondrial function, and reduced ...
Ubaida-Mohien C, Moaddel R, Spendiff S, MacMillan NJ, Filion ME, Morais JA, Candia J, Fitzgerald LF, Taivassalo T, Coen PM, Ferrucci L, Hepple RT.   +11 more
europepmc   +2 more sources

MMFuncPhos: A Multi-Modal Learning Framework for Identifying Functional Phosphorylation Sites and Their Regulatory Types. [PDF]

Adv Sci (Weinh)
The functions of most phosphorylation sites remain unknown, which is the “bottleneck” of phosphorylation modification studies. Here, a state‐of‐the‐art method, MMFuncPhos, is developed to predict functional phosphorylation sites based on a multi‐modal deep learning framework.
Xie J, Dong R, Zhu J, Lin H, Wang S, Lai L.   +5 more
europepmc   +2 more sources

Distal Tumors Elicit Distinctive Gene Expression Changes in Mouse Brain, Different from Those Induced by Arthritis [PDF]

, 2009
Background: Tumor progression is characterized by high mutation rates, each mutation potentially generating an “alarm” signal. The brain is the main integrator of signals arising in the periphery from changes in homeostasis.
Alvarez, Mariano J., Pitossi, Fernando Juan, Podhajcer, Osvaldo Luis, Rubinstein, Marcelo, Salibe, Mariano C., Stolovitzky, Gustavo   +5 more
core   +1 more source

Glucose-6-phosphate dehydrogenase contributes to the regulation of glucose uptake in skeletal muscle [PDF]

, 2016
The development of skeletal muscle insulin resistance is an early physiological defect, yet the intracellular mechanisms accounting for this metabolic defect remained unresolved. Here, we have examined the role of glucose-6-phosphate dehydrogenase (G6PDH)
Bruce, CR, Colgan, TD, Drummond, GR, Febbraio, MA, Greenfield, JR, Gregorevic, P, Henstridge, DC, Hoffman, NJ, Hong, YH, Iliades, P, Kingwell, BA, Kraakman, MJ, Lee-Young, RS, Lynch, GS, McConell, Glenn, Murphy, KT, Samocha-Bonet, D, Siebel, AL, Zivanovic, B   +18 more
core   +8 more sources

Microarray analysis of autoimmune diseases by machine learning procedures [PDF]

, 2009
—Microarray-based global gene expression profiling, with the use of sophisticated statistical algorithms is providing new insights into the pathogenesis of autoimmune diseases.
Armañanzas Arnedillo, Ruben, Bernales, Irantzu, Calvo Molinos, Borja, Fullaondo, Asier, Inza Cano, Iñaki, Larrañaga Múgica, Pedro, López Hoyos, Marcos, Martinez Taboada, Víctor, Ucar, Eduardo, Zubiaga, Ana María   +9 more
core   +2 more sources

The two PPX-GppA homologues from Mycobacterium tuberculosis have distinct biochemical activities [PDF]

, 2012
Inorganic polyphosphate (poly-P), guanosine pentaphosphate (pppGpp) and guanosine tetraphosphate (ppGpp) are ubiquitous in bacteria. These molecules play a variety of important physiological roles associated with stress resistance, persistence, and ...
Chen, Wy, Choi, MY, Huang, JD, Lu, Bt, Tanner, JA, Wang, Y, Watt, RM, Wong, LLY   +7 more
core   +1 more source

Therapeutic targeting in breast cancer for the treatment of lymph node metastasis: NADK.

Metastasis is the major cause of death from cancer.  Metastasis to the lymph node (“regional” metastasis) generally precedes distant metastasis, and we recently demonstrated that metastasis to the lymph nodes is a likely prerequisite for metastasis to the central nervous system (CNS) in humans with breast cancer (1-8).
Mamoor, Shahan
  +4 more sources

Functional identification and subcellular localization of NAD kinase in the protozoan parasite Giardia intestinalis

Revista Colombiana de Química, 2019
Nicotinamide adenine dinucleotide phosphate (NADP) is an essential biomolecule that participates in the redox homeostasis and synthesis of signaling compounds. NAD kinase (NADK) (EC 2.7.1.23/2.7.1.86) is the only enzyme capable of synthesizing NADP. This
Laura Marcela Jutinico Shubach, Luis Ernesto Contreras Rodríguez, Javier Eduardo García Castañeda, María Helena Ramírez Hernández   +3 more
doaj   +1 more source

The NAD kinase OsNADK1 affects the intracellular redox balance and enhances the tolerance of rice to drought

BMC Plant Biology, 2020
Background NAD kinases (NADKs) are the only known enzymes that directly phosphorylate NAD(H) to generate NADP(H) in different subcellular compartments. They participate in multiple life activities, such as modulating the NADP/NAD ratio, maintaining the ...
Xiang Wang, Bin-Bin Li, Tian-Tian Ma, Liang-Yu Sun, Li Tai, Chun-Hong Hu, Wen-Ting Liu, Wen-Qiang Li, Kun-Ming Chen   +8 more
doaj   +1 more source