Results 61 to 70 of about 2,008 (163)

S857 THE NUCLEOTIDE KINASE NADK CONSTITUTES A METABOLIC VULNERABILITY OF NOTCH1‐DRIVEN T‐ALL

HemaSphere, 2019
Background:Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer with a cumulative risk of ∼1 in 2,000 children by the age of 15 years and an increasing incidence over the last 30 years.Activating mutations in the NOTCH1gene are found in more than 60% of cases of T‐cell Acute Lymphoblastic leukaemia (T‐ALL) and are being targeted ...
E. De Braekeleer, M. Gu, C. Hervieux, J. Ino Hsu, D. Aspris, E. Abby, V. Baskar, H. Ponstingl, K. Tzelepis, S. Indraccolo, I. Jeremias, D. Fernandez Antoran, M.A. Goodell, P. H Jones, G.S. Vassiliou   +14 more
openaire   +1 more source

Hepatocyte‐Derived Extracellular Vesicles Deliver miR‐328‐3p to Trigger PP2A‐B56δ–Mediated p‐NLRP3S295‐Dependent Metaflammation in Macrophages upon Microcystin‐LR Exposure

Advanced Science, Volume 13, Issue 6, 30 January 2026.
Hepatocyte‐derived extracellular vesicles deliver miR‐328‐3p to trigger PP2A‐B56δ–mediated p‐NLRP3S295‐dependent metaflammation in macrophages upon microcystin‐LR exposure. 2‐DG, 2‐deoxy‐D‐glucose. B56δ, protein phosphatase 2A‐B56δ. ER, endoplasmic reticulum. iHD‐EV, inducible hepatocyte‐derived extracellular vesicles. IP3R, inositol 1,4,5‐triphosphate
Jia‐Shen Wu, Xin‐Yu Zhang, Xin‐Yu Ma, Yue‐Yue Wei, Lei‐Lei Wang, Ze‐Bang Du, Xiao‐Gang Xia, Lin Che, Dong‐Bei Guo, Han‐Ying Zheng, You‐Liang Yao, Wen‐Gang Li, Yu‐Chun Lin, Zhong‐Ning Lin   +13 more
wiley   +1 more source

MNADK, a novel liver-enriched mitochondrion-localized NAD kinase

Biology Open, 2013
Summary NADP+ and its reducing equivalent NADPH are essential for counteracting oxidative damage. Mitochondria are the major source of oxidative stress, since the majority of superoxide is generated from the mitochondrial respiratory chain. Because NADP+
Ren Zhang
doaj   +1 more source

NAD- and NADPH-Contributing Enzymes as Therapeutic Targets in Cancer: An Overview

Biomolecules, 2020
Actively proliferating cancer cells require sufficient amount of NADH and NADPH for biogenesis and to protect cells from the detrimental effect of reactive oxygen species.
Alvinsyah Adhityo Pramono, Gulam M. Rather, Herry Herman, Keri Lestari, Joseph R. Bertino   +4 more
doaj   +1 more source

Analytic and Numerical Study of Preheating Dynamics

, 1996
We analyze the phenomenon of preheating,i.e. explosive particle production due to parametric amplification of quantum fluctuations in the unbroken case, or spinodal instabilities in the broken phase, using the Minkowski space $O(N)$ vector model in the ...
A. D. Dolgov, A. D. Linde, A. Niemi, A. P. Prudnikov, B. L. Hu, B. L. Hu, C. Hermite, D. Boyanovsky, D. Boyanovsky, D. Boyanovsky, D. Boyanovsky, D. Boyanovsky, D. Boyanovsky, D. Boyanovsky, D. Boyanovsky, D. Boyanovsky, D. T. Son, E. Calzetta, E. Calzetta, E. Calzetta, E. Kolb, E. L. Ince, E. L. Ince, E. T. Whittaker, F. Cooper, F. Cooper, F. Cooper, F. Cooper, F. Cooper, F. Cooper, F. Cooper, F. Cooper, Greg W. Anderson, H. J. de Vega, I. I. Tkachev, I. S. Gradshteyn, J. F. J. Salgado, J. M. Eisenberg, J. P. Paz, J. P. Paz, J. Schwinger, J. Zinn-Justin, L. F. Abbott, L. Kofman, L. Kofman, L. Kofman, L. Kofman, L. V. Keldysh, M. Yoshimura, N. P. Landsman, N. Tetradis, N. Tetradis, P. M. Bakshi, P. M. Bakshi, R. D. Jordan, R. Holman, R. L. Kobes, R. L. Kobes, S. Habib, S. Klebnhikov, S. Mrowczynski, Y. Shtanov   +61 more
core   +3 more sources

Neuronal or Intestinal Knockdown of C. elegans nadk-1 Decreases Oxygen Consumption and Reactive Oxygen Species [PDF]

, 2023
Reactive oxygen species (ROS) such as H2O2 can damage cellular components and are formed as a byproduct of mitochondrial oxidative metabolism. Studies using the nematode C.
Regan, Jake
core   +1 more source

Novel Combination of Sorafenib and Celecoxib Provides Synergistic Anti-Proliferative and Pro-Apoptotic Effects in Human Liver Cancer Cells [PDF]

, 2013
Molecular targeted therapy has shown promise as a treatment for advanced hepatocellular carcinoma (HCC). Sorafenib, a multikinase inhibitor, recently received FDA approval for the treatment of advanced HCC.
A Cusimano, A Cusimano, A Cusimano, Antonella Cusimano, Antonina Azzolina, B Pyrzynska, B Yu, B Zhao, BC Lin, C Cai, CA Hall, CM Schmidt, D Bachvarov, D Foderà, D Levy, Dimcho Bachvarov, DM French, E Bertini, E Lapi, EN Gurzov, ET Sawey, G Montalto, Giuseppe Montalto, H Hao, H Koga, H Nakabayashi, HB El-Serag, HK Ho, James A. McCubrey, KS Yee, L Giannitrapani, M Cervello, M Cervello, M Cervello, M Cervello, M Cervello, M Cervello, M Cervello, M Nakamura, MA Kern, Manlio Vinciguerra, Melchiorre Cervello, MU Latasa, MZ Xu, N Inohara, N Lampiasi, N Lampiasi, N Ohoka, Nadia Lampiasi, PL Mercier, S Basu, S Miura, SS Cao, T Muramatsu, W Poh, X Zhang, Y Wang   +56 more
core   +3 more sources

A prognostic NAD+ metabolism-related gene signature for predicting response to immune checkpoint inhibitor in glioma

Frontiers in Oncology, 2023
BackgroundNicotinamide adenine dinucleotide (NAD+) metabolism is involved in a series of cancer pathogenesis processes, and is considered a promising therapeutic target for cancer treatment.
Cheng Jiang, Yujie Zhou, Lizhao Yan, Jianglin Zheng, Xuan Wang, Junjun Li, Xiaobing Jiang   +6 more
doaj   +1 more source

Integrative proteomic analysis provides novel therapeutic insights for etiological subtypes of diabetes

Diabetes, Obesity and Metabolism, Volume 27, Issue 12, Page 6894-6904, December 2025.
Abstract Aims Type 2 diabetes (T2D) is a highly heterogeneous disease characterised by subtypes with variations in aetiology, disease progression, and risk of complications. However, potential drug targets for these subtypes have not been explored. This study aims to investigate potential drug targets by integrating proteomics.
Jiahe Wei, Hanzhang Wu, Ningjian Wang, Jiahao Zhu, Ranjit Mohan Anjana, Aleksandr V. Sokolov, Helgi B. Schiöth, Viswanathan Mohan, Xiao Tan   +8 more
wiley   +1 more source

Exosomes in Metabolic Diseases: From Molecular Mechanisms to Clinical Applications

MedComm – Future Medicine, Volume 4, Issue 3, September 2025.
We summarize recent progress in exosome biology and elucidate their roles in interorgan communication networks underlying metabolic pathogenesis. We also comprehensively examine the evolving application of exosomes in metabolic disease management, with a focus on critically evaluating preclinical and clinical advances in exosome‐mediated therapeutic ...
Yanting Wu, Shanshan Yang, You Zhang, Zhiguang Su   +3 more
wiley   +1 more source