Results 61 to 70 of about 2,049 (165)

Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step [PDF]

, 2014
Aerobic glycolysis or the Warburg Effect (WE) is characterized by the increased metabolism of glucose to lactate. It remains unknown what quantitative changes to the activity of metabolism are necessary and sufficient for this phenotype.
Albeck, John G, Cluntun, Ahmad A, Huang, Lei, Hung, Yin P, Kim, Dongsung, Le, Anne, Liu, Xiaojing, Locasale, Jason W, Ser, Zheng, Shestov, Alexander A, Yellen, Gary   +10 more
core   +2 more sources

NAD Kinases: Metabolic Targets Controlling Redox Co-enzymes and Reducing Power Partitioning in Plant Stress and Development

Frontiers in Plant Science, 2018
NAD(H) and NADP(H) are essential co-enzymes which dominantly control a number of fundamental biological processes by acting as reducing power and maintaining the intracellular redox balance of all life kingdoms.
Bin-Bin Li, Xiang Wang, Li Tai, Tian-Tian Ma, Abdullah Shalmani, Wen-Ting Liu, Wen-Qiang Li, Kun-Ming Chen   +7 more
doaj   +1 more source

Exploring NAD(+) metabolism in host-pathogen interactions [PDF]

, 2016
Nicotinamide adenine dinucleotide (NAD+) is a vital molecule found in all living cells. NAD+ intracellular levels are dictated by its synthesis, using the de novo and/or salvage pathway, and through its catabolic use as co-enzyme or co-substrate.
Belinha, Ana, Gaifem, Joana, Mesquita, Inês Morais, Silvestre, Ricardo Jorge Leal   +3 more
core   +1 more source

Evaluation and Characterization of Post-Stroke Lung Damage in a Murine Model of Cerebral Ischemia [PDF]

, 2022
After stroke and other brain injuries, there is a high incidence of respiratory complications such as pneumonia or acute lung injury. The molecular mechanisms that drive the brain-lung interaction post-stroke have not yet been elucidated.
Bustamante, Alejandro, Faura, Júlia, Gasull Dalmau, Teresa, Ma, Feifei, Montaner, Joan, Penalba, Anna, Ramiro, Laura, Rosell Novel, Anna, Simats Oriol, Alba, Universitat Autònoma de Barcelona   +9 more
core   +1 more source

Enhancing β-Carotene Production in Escherichia coli by Perturbing Central Carbon Metabolism and Improving the NADPH Supply

Frontiers in Bioengineering and Biotechnology, 2020
Beta (β)-carotene (C40H56; a provitamin) is a particularly important carotenoid for human health. Many studies have focused on engineering Escherichia coli as an efficient heterologous producer of β-carotene.
Yuanqing Wu, Yuanqing Wu, Panpan Yan, Panpan Yan, Yang Li, Yang Li, Yang Li, Xuewei Liu, Xuewei Liu, Zhiwen Wang, Zhiwen Wang, Tao Chen, Tao Chen, Xueming Zhao, Xueming Zhao   +14 more
doaj   +1 more source

Issues concerning the waterfall of hybrid inflation

, 2011
We discuss the waterfall that ends hybrid inflation. Making some simplifying assumptions, that may be satisfied by GUT inflation models, two issues are addressed.
Lyth, David H.
core   +1 more source

Extramedullary relapse of multiple myeloma defined as the highest risk group based on deregulated gene expression data

Biomedical Papers, 2015
Background: Multiple myeloma (MM) is characterized by malignant proliferation of plasma cells (PC) which accumulate in the bone marrow (BM). The advent of new drugs has changed the course of the disease from incurable to treatable, but most patients ...
Sabina Sevcikova, Helena Paszekova, Lenka Besse, Lenka Sedlarikova, Veronika Kubaczkova, Martina Almasi, Ludek Pour, Roman Hajek   +7 more
doaj   +1 more source

ModuLand plug-in for Cytoscape: determination of hierarchical layers of overlapping network modules and community centrality [PDF]

, 2012
Summary: The ModuLand plug-in provides Cytoscape users an algorithm for determining extensively overlapping network modules. Moreover, it identifies several hierarchical layers of modules, where meta-nodes of the higher hierarchical layer represent ...
Adamcsek, Ahn, Bader, Balázs Papp, Balázs Szappanos, Fortunato, Ghosh, Ghosh, Guimera, István A. Kovács, Kovács, Kreimer, Mihalik, Morris, Máté Szalay-Bekő, Palla, Parter, Pál, Péter Csermely, Rhrissorrakrai, Rivera, Robin Palotai, Samal, Sethi, Shannon, Su, Tamames   +26 more
core   +6 more sources

MNADK, a novel liver-enriched mitochondrion-localized NAD kinase

Biology Open, 2013
Summary NADP+ and its reducing equivalent NADPH are essential for counteracting oxidative damage. Mitochondria are the major source of oxidative stress, since the majority of superoxide is generated from the mitochondrial respiratory chain. Because NADP+
Ren Zhang
doaj   +1 more source

NAD- and NADPH-Contributing Enzymes as Therapeutic Targets in Cancer: An Overview

Biomolecules, 2020
Actively proliferating cancer cells require sufficient amount of NADH and NADPH for biogenesis and to protect cells from the detrimental effect of reactive oxygen species.
Alvinsyah Adhityo Pramono, Gulam M. Rather, Herry Herman, Keri Lestari, Joseph R. Bertino   +4 more
doaj   +1 more source