Results 71 to 80 of about 2,049 (165)
Metabolic Dependencies in Pancreatic Cancer. [PDF]
, 2018 Pancreatic ductal adenocarcinoma (PDA) is a highly lethal cancer with a long-term survival rate under 10%. Available cytotoxic chemotherapies have significant side effects, and only marginal therapeutic efficacy. FDA approved drugs currently used against
Brody, Jonathan R. +3 more
core +1 more source
Advanced Science, Volume 13, Issue 6, 30 January 2026.Hepatocyte‐derived extracellular vesicles deliver miR‐328‐3p to trigger PP2A‐B56δ–mediated p‐NLRP3S295‐dependent metaflammation in macrophages upon microcystin‐LR exposure. 2‐DG, 2‐deoxy‐D‐glucose. B56δ, protein phosphatase 2A‐B56δ. ER, endoplasmic reticulum. iHD‐EV, inducible hepatocyte‐derived extracellular vesicles. IP3R, inositol 1,4,5‐triphosphate
Jia‐Shen Wu +13 more
wiley +1 more source
Neuronal or Intestinal Knockdown of C. elegans nadk-1 Decreases Oxygen Consumption and Reactive Oxygen Species [PDF]
, 2023 Reactive oxygen species (ROS) such as H2O2 can damage cellular components and are formed as a byproduct of mitochondrial oxidative metabolism. Studies using the nematode C.
Regan, Jake
core +1 more source
Analytic and Numerical Study of Preheating Dynamics
, 1996 We analyze the phenomenon of preheating,i.e. explosive particle production due to parametric amplification of quantum fluctuations in the unbroken case, or spinodal instabilities in the broken phase, using the Minkowski space $O(N)$ vector model in the ...
A. D. Dolgov +61 more
core +3 more sources
Novel Combination of Sorafenib and Celecoxib Provides Synergistic Anti-Proliferative and Pro-Apoptotic Effects in Human Liver Cancer Cells [PDF]
, 2013 Molecular targeted therapy has shown promise as a treatment for advanced hepatocellular carcinoma (HCC). Sorafenib, a multikinase inhibitor, recently received FDA approval for the treatment of advanced HCC.
A Cusimano +56 more
core +3 more sources
Diabetes, Obesity and Metabolism, Volume 27, Issue 12, Page 6894-6904, December 2025.Abstract Aims Type 2 diabetes (T2D) is a highly heterogeneous disease characterised by subtypes with variations in aetiology, disease progression, and risk of complications. However, potential drug targets for these subtypes have not been explored. This study aims to investigate potential drug targets by integrating proteomics.
Jiahe Wei +8 more
wiley +1 more source
Frontiers in Oncology, 2023 BackgroundNicotinamide adenine dinucleotide (NAD+) metabolism is involved in a series of cancer pathogenesis processes, and is considered a promising therapeutic target for cancer treatment.
Cheng Jiang +6 more
doaj +1 more source
Exosomes in Metabolic Diseases: From Molecular Mechanisms to Clinical Applications
MedComm – Future Medicine, Volume 4, Issue 3, September 2025.We summarize recent progress in exosome biology and elucidate their roles in interorgan communication networks underlying metabolic pathogenesis. We also comprehensively examine the evolving application of exosomes in metabolic disease management, with a focus on critically evaluating preclinical and clinical advances in exosome‐mediated therapeutic ...
Yanting Wu +3 more
wiley +1 more source
Arabidopsis peroxisome proteomics [PDF]
, 2013 The analytical depth of investigation of the peroxisomal proteome of the model plant Arabidopsis thaliana has not yet reached that of other major cellular organelles such as chloroplasts or mitochondria.
Behrens, Christof +3 more
core +3 more sources
Advanced Science, Volume 12, Issue 19, May 22, 2025.LACK156‐173 is internalized into RA‐FLSs via CAPN2‐mediated endocytosis and inhibits the aggressive phenotype of RA‐FLSs by restoring dysregulated fatty acid synthesis metabolism mediated by overexpressed FASN. The findings suggest that targeting the restoration of fatty acid metabolism could potentially alleviate synovial invasion and joint damage in ...
Jianling Su +17 more
wiley +1 more source