Results 1 to 10 of about 239,596 (347)
NADPH homeostasis in cancer: functions, mechanisms and therapeutic implications
Signal Transduction and Targeted Therapy, 2020 Nicotinamide adenine dinucleotide phosphate (NADPH) is an essential electron donor in all organisms, and provides the reducing power for anabolic reactions and redox balance.
Huai-Qiang Ju, Dan Xie, Rui-Hua Xu
exaly +2 more sources
NADPH Oxidases (NOX): An Overview from Discovery, Molecular Mechanisms to Physiology and Pathology
Antioxidants, 2021 The reactive oxygen species (ROS)-producing enzyme NADPH oxidase (NOX) was first identified in the membrane of phagocytic cells. For many years, its only known role was in immune defense, where its ROS production leads to the destruction of pathogens by ...
Annelise Vermot +2 more
exaly +2 more sources
NAD- and NADPH-Contributing Enzymes as Therapeutic Targets in Cancer: An Overview
Biomolecules, 2020 Actively proliferating cancer cells require sufficient amount of NADH and NADPH for biogenesis and to protect cells from the detrimental effect of reactive oxygen species.
Alvinsyah Adhityo Pramono +4 more
doaj +2 more sources
Bioengineering & Translational Medicine, 2020 Mitochondrial NADPH protects cells against mitochondrial oxidative stress by serving as an electron donor to antioxidant defense systems. However, due to technical challenges, it still remains unknown as to the pool size of mitochondrial NADPH, its ...
Sun Jin Moon +3 more
doaj +2 more sources
MESH1 is a cytosolic NADPH phosphatase that regulates ferroptosis
Nature Metabolism, 2020 Critical to the bacterial stringent response is the rapid relocation of resources from proliferation toward stress survival through the respective accumulation and degradation of (p)ppGpp by RelA and SpoT homologues. While mammalian genomes encode MESH1,
Chien-Kuang Cornelia Ding +2 more
exaly +2 more sources
Acute stimulation of glucose metabolism by H2O2 sustains the NADPH steady-state under oxidative stress [PDF]
Redox BiologyOxidative stress reprograms metabolic flux from glycolysis to the pentose phosphate pathway. Recently, it has been proposed that NADPH acts as a key molecule in pentose phosphate pathway regulation by exerting negative feedback through tonic inhibition ...
C. Aburto, I. Ruminot, A. San Martín
doaj +2 more sources
NADPH-generating systems in bacteria and archaea
Frontiers in Microbiology, 2015 Reduced nicotinamide adenine dinucleotide phosphate (NADPH) is an essential electron donor in all organisms. It provides the reducing power that drives numerous anabolic reactions, including those responsible for the biosynthesis of all major cell ...
Sebastiaan K. Spaans +3 more
doaj +2 more sources
NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets
Nature Reviews Cardiology, 2019 Yixuan Zhang, Hua Cai
exaly +2 more sources
Spectrophotometric assays for measuring redox biomarkers in blood and tissues: the NADPH network
Redox Report, 2018 Nicotinamide adenine dinucleotide (NAD+/NADH) along with its phosphorylated form (NADP+/NADPH) are two molecules ubiquitously present in all organisms, and they play key roles as cofactors in fundamental catabolic and anabolic processes, respectively ...
Aristidis S. Veskoukis +4 more
doaj +2 more sources
NADPH oxidases in Parkinson’s disease: a systematic review
Molecular Neurodegeneration, 2017 Parkinson’s disease (PD) is a progressive movement neurodegenerative disease associated with a loss of dopaminergic neurons in the substantia nigra of the brain. Oxidative stress, a condition that occurs due to imbalance in oxidant and antioxidant status,
Karim Belarbi +4 more
doaj +2 more sources