Results 1 to 10 of about 329,119 (207)
NADPH alleviates LPS-induced neuropathology and depression-like behaviors by suppressing microglial inflammatory response [PDF]
Translational PsychiatryOur study investigated the role of nicotinamide adenine dinucleotide phosphate (NADPH) in neuroinflammation-associated depression-like behaviors. Using a lipopolysaccharide (LPS)-induced mouse model of depression, we found that NADPH significantly ...
Dian He +8 more
doaj +2 more sources
Frontiers in Bioscience-Landmark, 2022 Fatty acid metabolism has attracted extensive attention for its key role in the occurrence and development of tumors. Fatty acids not only participate in the biosynthesis of phospholipids in the membrane to overcome the demand for rapidly proliferating ...
Hongdan Chen +5 more
doaj +1 more source
The Possibility of Destruction of Cellular NADPH in the Presence of Free Fe(II) Ion, Arsine, and Other Hazardous Species [PDF]
Research in Molecular Medicine, 2022 Background: As the nicotinamide adenine dinucleotide phosphate (NADPH) is the key natural electron generator of the alive cells, investigation of the possibility of inactivation or even destruction of it by hazardous chemical molecules or ions seems to ...
Seyyed Amir Siadati +2 more
doaj
Redox Report, 2021 Objectives The study explores the protective role of the peripheral serum of limb remote ischemic postconditioning (LRIP) in reducing the reactive oxygen species (ROS) levels and neutrophil activation, which are responsible for the deleterious ...
Gangling Chen +7 more
doaj +1 more source
Glucose as a Major Antioxidant: When, What for and Why It Fails?
Antioxidants, 2020 A human organism depends on stable glucose blood levels in order to maintain its metabolic needs. Glucose is considered to be the most important energy source, and glycolysis is postulated as a backbone pathway.
Andriy Cherkas +4 more
doaj +1 more source
Biomolecular Concepts, 2022 Systemic sclerosis (SSc) is an immune disorder characterized by diffuse fibrosis and vascular abnormalities of the affected organs. Although the etiopathology of this disease is largely unknown, endothelial damage and oxidative stress appear implicated ...
Posadino Anna Maria +7 more
doaj +1 more source
Preferential utilization of NADPH as the endogenous electron donor for NAD(P)H:quinone oxidoreductase 1 (NQO1) in intact pulmonary arterial endothelial cells [PDF]
, 2009 The goal was to determine whether endogenous cytosolic NAD(P)H:quinone oxidoreductase 1 (NQO1) preferentially uses NADPH or NADH in intact pulmonary arterial endothelial cells in culture.
Bongard, Robert D +3 more
core +2 more sources
Bioresources and Bioprocessing, 2022 NADPH provides the reducing power for decomposition of reactive oxygen species (ROS), making it an indispensable part during ROS defense. It remains uncertain, however, if living cells respond to the ROS challenge with an elevated intracellular NADPH ...
Jingyi Li +7 more
doaj +1 more source
Characterization of theThreshold for NAD(P)H:quinone Oxidoreductase Activity in Intact Sulforaphane-treated Pulmonary Arterial Endothelial Cells [PDF]
, 2011 Treatment of bovine pulmonary arterial endothelial cells in culture with the phase II enzyme inducer sulforaphane (5 μM, 24 h; sulf-treated) increased cell-lysate NAD(P)H:quinone oxidoreductase (NQO1) activity by 5.7 ± 0.6 (mean ± SEM)-fold, but intact ...
Bongard, Robert D. +5 more
core +2 more sources
Metabolites, 2019 NADPH is the primary source of cellular reductant for biosynthesis, and strategies for increasing productivity via metabolic engineering need to take account of the requirement for reducing power.
Edward N. Smith +3 more
doaj +1 more source