Results 11 to 20 of about 182,746 (311)

Increasing NADPH impairs fungal H2O2 resistance by perturbing transcriptional regulation of peroxiredoxin

Bioresources and Bioprocessing, 2022
NADPH provides the reducing power for decomposition of reactive oxygen species (ROS), making it an indispensable part during ROS defense. It remains uncertain, however, if living cells respond to the ROS challenge with an elevated intracellular NADPH ...
Jingyi Li, Yanwei Sun, Feiyun Liu, Yao Zhou, Yunfeng Yan, Zhemin Zhou, Ping Wang, Shengmin Zhou   +7 more
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Elementary Flux Mode Analysis Revealed Cyclization Pathway as a Powerful Way for NADPH Regeneration of Central Carbon Metabolism. [PDF]

PLoS ONE, 2015
NADPH regeneration capacity is attracting growing research attention due to its important role in resisting oxidative stress. Besides, NADPH availability has been regarded as a limiting factor in production of industrially valuable compounds. The central
Bin Rui, Yin Yi, Tie Shen, Meijuan Zheng, Wenwei Zhou, Honglin Du, Yadong Fan, Yongkang Wang, Zhengdong Zhang, Shengsheng Xu, Zhijie Liu, Han Wen, Xiaoyao Xie   +12 more
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The Crosstalk Between Cancer Cells and Neutrophils Enhances Hepatocellular Carcinoma Metastasis via Neutrophil Extracellular Traps-Associated Cathepsin G Component: A Potential Therapeutic Target

Journal of Hepatocellular Carcinoma, 2021
Xiangqian Guan, Yuyan Lu, Heping Zhu, Shuqi Yu, Wenxiu Zhao, Xiaoqin Chi, Chengrong Xie, Zhenyu Yin Department of Hepatobiliary Surgery, Zhongshan Hospital, Xiamen University, Fujian Provincial Key Laboratory of Chronic Liver Disease and Hepatocellular ...
Guan X, Lu Y, Zhu H, Yu S, Zhao W, Chi X, Xie C, Yin Z   +7 more
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Assessment of Glucose-6-Phosphate Dehydrogenase Deficiency and Anaemia in Apparently Healthy Students in Gombe State University [PDF]

Global Journal of Environmental Science & Sustainability
Glucose-6-phosphate dehydrogenase (G6PD) is a key regulatory enzyme in the pentose phosphate pathway (PPP) which produces nicotiamide adenine dinucleotide phosphate (NADPH) to maintain an adequate reducing environment in cells and is especially important
Lazarus J. Goje, Abubakar M. Hammari, Fauziya J. Kamara, Adamu J. Abubakar, Adamu U. Bashir   +4 more
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The folate cycle is a new metabolic weakness of cancer

Molecular & Cellular Oncology, 2017
Cancer cells harness nutrients to support its rapid proliferation through metabolic reprogramming. Our report identified folate cycle as a metabolic target in hepatocellular carcinoma.
Derek Lee, Carmen Chak-Lui Wong
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Cytosolic ME1 integrated with mitochondrial IDH2 supports tumor growth and metastasis

Redox Biology, 2020
NADPH is a pivotal cofactor that maintains redox homeostasis and lipogenesis in cancer cells and interference with NADPH production is a promising approach for treating cancer.
Chang Shao, Wenjie Lu, Ye Du, Wenchao Yan, Qiuyu Bao, Yang Tian, Guangji Wang, Hui Ye, Haiping Hao   +8 more
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STAMP2 Attenuates Cardiac Dysfunction and Insulin Resistance in Diabetic Cardiomyopathy via NMRAL1-Mediated NF-κB Inhibition in Type 2 Diabetic Rats

Diabetes, Metabolic Syndrome and Obesity, 2022
Zhan Gao,1,2 Yun Ti,1 Bin Lu,1 Fang-qiang Song,1,3 Lei Zhang,1 Bo-ang Hu,1 Jia-ying Xie,1 Wei Zhang,1 Lu Han,1,4 Ming Zhong1 1The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health ...
Gao Z, Ti Y, Lu B, Song F, Zhang L, Hu B, Xie J, Zhang W, Han L, Zhong M   +9 more
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Oxidative pentose phosphate pathway and glucose anaplerosis support maintenance of mitochondrial NADPH pool under mitochondrial oxidative stress

Bioengineering & Translational Medicine, 2020
Mitochondrial NADPH protects cells against mitochondrial oxidative stress by serving as an electron donor to antioxidant defense systems. However, due to technical challenges, it still remains unknown as to the pool size of mitochondrial NADPH, its ...
Sun Jin Moon, Wentao Dong, Gregory N. Stephanopoulos, Hadley D. Sikes   +3 more
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NADPH Oxidase and Neurodegeneration [PDF]

Current Neuropharmacology, 2012
NADPH oxidase (Nox) is a unique, multi-protein, electron transport system that produces large amounts of superoxide via the reduction of molecular oxygen. Nox-derived reactive oxygen species (ROS) are known to be involved in a variety of physiological processes, including host defense and signal transduction.
Hernandes, Marina S, Britto, Luiz R G
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Application of different methods used to transfect small molecule NADPH into cells [PDF]

Jichu yixue yu linchuang
Objective To compare the three different methods for direct transfection of small exogenous nicotinamide adenine dinucleotide phosphate(NADPH) into cells by a non-metabolic pathway.
LI Haoyue, DU Wenjing, LI Wei
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