Characterization of the novel ene reductase Ppo-Er1 from paenibacillus polymyxa [PDF]
, 2020 Ene reductases enable the asymmetric hydrogenation of activated alkenes allowing the manufacture of valuable chiral products. The enzymes complement existing metal- and organocatalytic approaches for the stereoselective reduction of activated C=C double ...
Aregger, David +2 more
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Bioengineering & Translational Medicine, 2020 Mitochondrial NADPH protects cells against mitochondrial oxidative stress by serving as an electron donor to antioxidant defense systems. However, due to technical challenges, it still remains unknown as to the pool size of mitochondrial NADPH, its ...
Sun Jin Moon +3 more
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Platelets, 2019 Reactive oxygen species (ROS) generation is critical in the regulation of platelets, which has important implications in the modulation of hemostasis and thrombosis. Nonetheless, despite several assays have been described and successfully utilized in the
Aisha Alsheikh Abubaker +4 more
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Assessment of Glucose-6-Phosphate Dehydrogenase Deficiency and Anaemia in Apparently Healthy Students in Gombe State University [PDF]
Global Journal of Environmental Science & SustainabilityGlucose-6-phosphate dehydrogenase (G6PD) is a key regulatory enzyme in the pentose phosphate pathway (PPP) which produces nicotiamide adenine dinucleotide phosphate (NADPH) to maintain an adequate reducing environment in cells and is especially important
Lazarus J. Goje +4 more
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Label-Free Metabolic Classification of Single Cells in Droplets Using the Phasor Approach to Fluorescence Lifetime Imaging Microscopy. [PDF]
, 2019 Characterization of single cell metabolism is imperative for understanding subcellular functional and biochemical changes associated with healthy tissue development and the progression of numerous diseases.
Aghaamoo, Mohammad +4 more
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NADPH Oxidase and Neurodegeneration [PDF]
Current Neuropharmacology, 2012 NADPH oxidase (Nox) is a unique, multi-protein, electron transport system that produces large amounts of superoxide via the reduction of molecular oxygen. Nox-derived reactive oxygen species (ROS) are known to be involved in a variety of physiological processes, including host defense and signal transduction.
Hernandes, Marina S, Britto, Luiz R G
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The folate cycle is a new metabolic weakness of cancer
Molecular & Cellular Oncology, 2017 Cancer cells harness nutrients to support its rapid proliferation through metabolic reprogramming. Our report identified folate cycle as a metabolic target in hepatocellular carcinoma.
Derek Lee, Carmen Chak-Lui Wong
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Application of different methods used to transfect small molecule NADPH into cells [PDF]
Jichu yixue yu linchuangObjective To compare the three different methods for direct transfection of small exogenous nicotinamide adenine dinucleotide phosphate(NADPH) into cells by a non-metabolic pathway.
LI Haoyue, DU Wenjing, LI Wei
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The Ca2+-Regulation of the Mitochondrial External NADPH Dehydrogenase in Plants Is Controlled by Cytosolic pH. [PDF]
PLoS ONE, 2015 NADPH is a key reductant carrier that maintains internal redox and antioxidant status, and that links biosynthetic, catabolic and signalling pathways.
Meng-Shu Hao +4 more
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Identifying Novel Inhibitors of RpFabG in Typhus-inducing Rickettsia prowazekii [PDF]
, 2019 Epidemic typhus is a rickettsial disease that is contracted via ticks and lice found on the flying squirrel. The disease is caused by Rickettsia prowazekii, an intracellular, gram-negative coccobacillus.
Panatpur, Aparna
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