Results 21 to 30 of about 143,942 (291)

A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease

Nature Communications, 2019
Development of cirrhosis in individuals with non-alcoholic fatty liver disease can predict mortality. Here the authors used a unique twin and family cohort to identify a gut microbiome-derived 16sRNA signature that can detect cirrhosis in individuals ...
Cyrielle Caussy, Anupriya Tripathi, Greg Humphrey, Shirin Bassirian, Seema Singh, Claire Faulkner, Ricki Bettencourt, Emily Rizo, Lisa Richards, Zhenjiang Z. Xu, Michael R. Downes, Ronald M. Evans, David A. Brenner, Claude B. Sirlin, Rob Knight, Rohit Loomba   +15 more
doaj   +1 more source

Phenotypical heterogeneity linked to adipose tissue dysfunction in patients with type 2 diabetes [PDF]

, 2016
Adipose tissue (AT) inflammation leads to increased free fatty acid (FFA) efflux and ectopic fat deposition, but whether AT dysfunction drives selective fat accumulation in specific sites remains unknown.
ANGELICO, Francesco, BARCHETTA, ILARIA, BARONI, Marco Giorgio, BERTOCCINI, LAURA, CATALANO, Carlo, CAVALLO, Maria Gisella, CIMINI, FLAVIA AGATA, DEL VESCOVO, RICCARDO, FRAIOLI, Antonio, Maria Del Ben,, Martino, Michele Di, Morini, Sergio, POLIMENI, LICIA   +12 more
core   +1 more source

Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC

Hepatology, EarlyView., 2022
Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wen‐Hua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen   +11 more
wiley   +1 more source

Non-alcoholic fatty liver disease connections with fat-free tissues: A focus on bone and skeletal muscle [PDF]

, 2017
The estimates of global incidence and prevalence of non-alcoholic fatty liver disease (NAFLD) are worrisome, due to the parallel burden of obesity and its metabolic complications. Indeed, excess adiposity and insulin resistance represent two of the major
Chiesa, Claudio, Donini, Lorenzo Maria, Lenzi, Andrea, Pacifico, Lucia, Poggiogalle, Eleonora   +4 more
core   +2 more sources

Relationship between NAFLD and coronary artery disease: A Mendelian randomization study

Hepatology, EarlyView., 2022
Abstract Background and Aims There is an ongoing debate on whether NAFLD is an active contributor or an innocent bystander in the pathogenesis of coronary artery disease (CAD). The aim of the present study was to assess the causal relationship between NAFLD and CAD.
Zhewen Ren, Pomme I. H. G. Simons, Anke Wesselius, Coen D. A. Stehouwer, Martijn C. G. J. Brouwers   +4 more
wiley   +1 more source

Radiomics‐based model for accurately distinguishing between severe acute respiratory syndrome associated coronavirus 2 (SARS‐CoV‐2) and influenza A infected pneumonia

MedComm, 2020
Clinicians have been faced with the challenge of differentiating between severe acute respiratory syndrome associated coronavirus 2 (SARS‐CoV‐2) infected pneumonia (NCP) and influenza A infected pneumonia (IAP), a seasonal disease that coincided with the
Qi‐Qiang Zeng, Kenneth I. Zheng, Jun Chen, Zheng‐Hao Jiang, Tian Tian, Xiao‐Bo Wang, Hong‐Lei Ma, Ke‐Hua Pan, Yun‐Jun Yang, Yong‐Ping Chen, Ming‐Hua Zheng   +10 more
doaj   +1 more source

Association between thyroid function and assessment of hepatic fat and iron contents by magnetic resonance imaging

Endocrine Connections, 2022
The associations of thyroid function parameters with non-alcoholic fatty liver disease (NAFLD) and hepatic iron overload are not entirely clear. We have cross-sectionally investigated these associations among 2734 participants of two population-based ...
Till Ittermann, Rehman Mehmood Khattak, Marcello R P Markus, Jens-Peter Kühn, Marie-Luise Kromrey, Giovanni Targher, Antje Steveling, Matthias Nauck, Henry Völzke   +8 more
doaj   +1 more source

Reduced expression of chemerin in visceral adipose tissue associates with hepatic steatosis in patients with obesity [PDF]

, 2016
Objective: This study aimed to evaluate whether circulating levels and/or visceral adipose tissue (VAT) expression of recently described adipokines associate with histopathological severity of nonalcoholic fatty liver disease (NAFLD), independent of ...
Alfadda, Behari, Bekaert, Bozaoglu, Brunt, Bugianesi, Chakaroun, Deng, Docke, Donnelly, Ehrlund, Fuster, Greulich, Gruben, Haukeland, Heiker, Kanda, Kim, Kleiner, Luangsay, Mahdi, Marchesini, Musso, Ouwens, Polyzos, Polyzos, Rivera, Saxena, Seki, Sell, Sell, Souza Batista, Wittamer, Wittamer, Wolfs, Wong, Yang, Yilmaz, Zelber-Sagi, Zeng   +39 more
core   +1 more source

NAFLD: A multisystem disease

Journal of Hepatology, 2015
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in Western countries that is predicted to become also the most frequent indication for liver transplantation by 2030. Over the last decade, it has been shown that the clinical burden of NAFLD is not only confined to liver-related morbidity and mortality, but ...
CD Byrne, TARGHER, Giovanni
openaire   +4 more sources

Hyperinsulinemia predisposes to NAFLD [PDF]

Indian Journal of Clinical Biochemistry, 2008
Metabolic syndrome contributes to pathogenesis of Type-2 diabetes and CAD. Insulin Resistance is the key factor of metabolic syndrome implicated in development of Non Alcoholic Fatty Liver Disease (NAFLD). In present study we have investigated the prevalence of NAFLD in metabolic syndrome and contribution of metabolic risk factors in causation of NAFLD
Sandhya, Mishra, Dharamveer, Yadav, Monika, Gupta, Hemant, Mishra, Praveen, Sharma   +4 more
openaire   +2 more sources