Results 11 to 20 of about 634,915 (204)

Synthesis and Evaluation of Reactive Oxygen Species Sensitive Prodrugs of a NAMPT Inhibitor FK866 [PDF]

Molecules, 2022
NAMPT is an attractive target in cancer therapy and numerous NAMPT inhibitors have been developed. However, the clinical activities of NAMPT inhibitors have displayed disappointing results in clinical trials for their dose-limiting toxicities.
Zili Xu, Huihui Wang, Haixia Liu, Hongli Chen, Biao Jiang   +4 more
doaj   +3 more sources

A Novel NAMPT Inhibitor-Based Antibody-Drug Conjugate Payload Class for Cancer Therapy. [PDF]

Bioconjug Chem, 2022
[Image: see text] Inhibition of intracellular nicotinamide phosphoribosyltransferase (NAMPT) represents a new mode of action for cancer-targeting antibody–drug conjugates (ADCs) with activity also in slowly proliferating cells.
Böhnke N, Berger M, Griebenow N, Rottmann A, Erkelenz M, Hammer S, Berndt S, Günther J, Wengner AM, Stelte-Ludwig B, Mahlert C, Greven S, Dietz L, Jörißen H, Barak N, Bömer U, Hillig RC, Eberspaecher U, Weiske J, Giese A, Mumberg D, Nising CF, Weinmann H, Sommer A.   +23 more
europepmc   +3 more sources

NAMPT haploinsufficiency is a therapeutic vulnerability to NAMPT inhibition in -7/-7q MDS [PDF]

Biomarker Research
Chromosome 7 abnormalities -7 and -7q define a high-risk subset of myelodysplastic syndromes (MDS) with poor prognosis. The NAMPT gene, located at 7q22.3, encodes a rate limiting enzyme (nicotinamide phosphoribosyl transferase) in the NAD+ salvage ...
Nemo Ikonen, Tanja Ruokoranta, Salla Hyyppä, Ella Sinervuori, Juho J. Miettinen, Joseph Saad, Markus Vähä-Koskela, Caroline A. Heckman   +7 more
doaj   +2 more sources

Inhibition of NAMPT by PAK4 Inhibitors

International Journal of Molecular Sciences
The serine/threonine kinase PAK4 plays a crucial role in regulating cell proliferation, survival, migration, and invasion. Overexpression of PAK4 correlates with poor prognosis in some cancers. KPT-9274, a PAK4 inhibitor, significantly reduces the growth
Audrey Minden, Yiling Wang
core   +3 more sources

The nicotinamide phosphoribosyltransferase inhibitor FK866 restricts influenza A virus replication by perturbing viral polymerase activity [PDF]

Journal of Virology
Nicotinamide phosphoribosyltransferase (NAMPT), a key rate-limiting enzyme in NAD+ synthesis, plays important roles in various physiological and pathological processes.
Changjie Lv, Shuang Wang, Mingyue Song, Jianmei Wu, Wanxin Wei, Guijie Guo   +5 more
doaj   +2 more sources

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis [PDF]

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +2 more sources

Oleate ameliorates palmitate-induced reduction of NAMPT activity and NAD levels in primary human hepatocytes and hepatocarcinoma cells

Lipids in Health and Disease, 2017
Background Nicotinamide phosphoribosyltransferase (NAMPT) and nicotinamide adenine dinucleotide (NAD) levels are crucial for liver function. The saturated fatty acid palmitate and the unsaturated fatty acid oleate are the main free fatty acids in adipose
Melanie Penke, Susanne Schuster, Theresa Gorski, Rolf Gebhardt, Wieland Kiess, Antje Garten   +5 more
doaj   +2 more sources

Inhibiting Nampt signaling promotes M2 macrophage polarization to enhance bone regeneration in periodontitis [PDF]

Frontiers in Bioengineering and Biotechnology
BackgroundDysregulated macrophage polarization is a fundamental cause of bone loss in periodontitis. However, the role of nicotinamide phosphoribosyltransferase (NAMPT) in macrophage regulation within periodontitis remains unclear.
Yixin Xia, Kexin Xie, Chunhui Liao, Zhanyi Ye, Baojun Long   +4 more
doaj   +2 more sources

Molecular Effects of the Nampt Inhibitor FK866 on Leukemia Cells [PDF]

, 2016
Aberrant activation of metabolic pathways has emerged as an hallmark of proliferating cancer cells and pharmaceutical approaches targeting cell metabolism hold great potential for cancer treatment.
Zucal, Chiara
core   +2 more sources

Review of various NAMPT inhibitors for the treatment of cancer

Frontiers in Pharmacology, 2022
Nicotinamide phosphoribosyltransferase (NAMPT) is a rate-limiting enzyme in the NAD salvage pathway of mammalian cells and is overexpressed in numerous types of cancers. These include breast cancer, ovarian cancer, prostate cancer, gastric cancer, colorectal cancer, glioma, and b-cell lymphoma.
Yichen Wei, Yichen Wei, Haotian Xiang, Wenqiu Zhang   +3 more
openaire   +3 more sources