Results 21 to 30 of about 634,915 (204)
Recent Advances in NAMPT Inhibitors: A Novel Immunotherapic Strategy [PDF]
Frontiers in Pharmacology, 2020 Nicotinamide adenine dinucleotide (NAD) is a cofactor of many enzymatic reactions as well as being a substrate for a number of NAD-consuming enzymes (e.g., PARPS, sirtuins, etc). NAD can be synthesized de novo starting from tryptophan, nicotinamide, nicotinic acid, or nicotinamide riboside from the diet.
Galli, Ubaldina +5 more
openaire +6 more sources
Nicotinamide phosphoribosyltransferase may be involved in age-related brain diseases. [PDF]
PLoS ONE, 2012 Nicotinamide phosphoribosyltransferase (NAMPT) is a key enzyme for nicotinamide adenine dinucleotide (NAD) biosynthesis, and can be found either intracellularly (iNAMPT) or extracellularly (eNAMPT).
Li-Ying Liu +6 more
doaj +1 more source
, 2023 Introduction Targeted-therapy and immune checkpoint inhibitors (ICIs) have notably improved the treatment of BRAF-mutated metastatic melanoma (MM) patients; however resistance to treatment dramatically impacts on the survival of patients.
Valentina Audrito. +9 more
core +1 more source
Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6 [PDF]
, 2013 The authors acknowledge TENOVUS Tayside for funding the studyTenovin-6 (Tnv-6) is a bioactive small molecule with anti-neoplastic activity. Inhibition of the Sirtuin class of protein deacetylases with activation of p53 function is associated with the pro-
Coates, Philip J. +43 more
core +1 more source
Nicotinamide phosphoribosyl transferase (Nampt) is required for de novo lipogenesis in tumor cells. [PDF]
PLoS ONE, 2012 Tumor cells have increased metabolic requirements to maintain rapid growth. In particular, a highly lipogenic phenotype is a hallmark of many tumor types, including prostate. Cancer cells also have increased turnover of nicotinamide adenine dinucleotide (
Sarah C Bowlby +3 more
doaj +1 more source
Intracellular cAMP contents regulate NAMPT expression via induction of C/EBPβ in adipocytes [PDF]
, 2020 A decline in intracellular nicotinamide adenine mononucleotide (NAD+) causes adipose tissue dysfunction. Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the rate-limiting step in the NAD+ biosynthesis pathway.
Wada, Kenjiro +5 more
core +1 more source
Frontiers in Pharmacology, 2021 Opioids are a potential adjuvant treatment for certain cancers; while they are primarily used to relieve chronic pain, these drugs may also affect cancer progression and recurrence. Dezocine is one opioid commonly used in China, but its effects on cancer
Chenyang Xue +10 more
doaj +1 more source
Synthetic lethality of PARP and NAMPT inhibition in triple‐negative breast cancer cells
EMBO Molecular Medicine, 2012 PARP inhibitors have been proposed as a potential targeted therapy for patients with triple‐negative (ER‐, PR‐, HER2‐negative) breast cancers. However, it is as yet unclear as to whether single agent or combination therapy using PARP inhibitors would be ...
Ilirjana Bajrami +6 more
doaj +1 more source
Molecules, 2023 Targeting cancer cells that are highly dependent on the nicotinamide adenine dinucleotide (NAD+) metabolite is a promising therapeutic strategy. Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme catalyzing NAD+ production ...
Paulina Biniecka +16 more
doaj +1 more source
Molecules, 2020 Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) is an attractive therapeutic strategy for targeting cancer metabolism. So far, many potent NAMPT inhibitors have been developed and shown to bind to two unique tunnel-shaped cavities existing ...
Sei-ichi Tanuma +17 more
doaj +1 more source