Results 31 to 40 of about 634,915 (204)
Development of cancer targeted Nampt inhibitors [PDF]
, 2021 The purpose of this research is the discovery of a highly potent pharmaceutical that can selectively cause apoptosis in various cancer cells. To utilize hydrophobic properties of carboranes, 1,7-dicarba-closo-dodecaborane (m-CB) has been selected as a template to synthesize new targeted antitumor agent.
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Neoplasia: An International Journal for Oncology Research, 2013 Nicotinamide adenine dinucleotide (NAD) is a critical metabolite that is required for a range of cellular reactions. A key enzyme in the NAD salvage pathway is nicotinamide phosphoribosyl transferase (NAMPT), and here, we describe GNE-618, an NAMPT ...
Yang Xiao +14 more
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Discovery of Novel Inhibitors and Fluorescent Probe Targeting NAMPT [PDF]
Scientific Reports, 2015 AbstractNicotinamide phosphoribosyltransferase (NAMPT) is a promising antitumor target. Novel NAMPT inhibitors with diverse chemotypes are highly desirable for development of antitumor agents. Using high throughput screening system targeting NAMPT on a chemical library of 30000 small-molecules, we found a non-fluorescent compound F671-0003 and a ...
Xia Wang +12 more
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Frontiers in Cell and Developmental Biology, 2022 BRD4, a chromatin modifier frequently upregulated in a variety of neoplasms including hepatocellular cancer (HCC), promotes cancer cell growth by activating oncogenes through its interaction with acetylated histone tails of nucleosomes.
Cho-Hao Lin +12 more
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Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors [PDF]
Molecular Cancer Therapeutics, 2017 Abstract Cancer cells are highly reliant on NAD+-dependent processes, including glucose metabolism, calcium signaling, DNA repair, and regulation of gene expression. Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme for NAD+ salvage from nicotinamide, has been investigated as a target for anticancer therapy ...
Julie L, Wilsbacher +32 more
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Cell Reports, 2021 Summary: Although tumor-infiltrating lymphocytes (TILs) maintain their ability to proliferate, persist, and eradicate tumors, they are frequently dysfunctional in situ.
Yuetong Wang +16 more
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Oxygen-dependent interactions between the ruthenium cage and the photoreleased inhibitor in NAMPT-targeted photoactivated chemotherapy [PDF]
Photoactivated chemotherapy agents show a promising ability to kill cancer cells under the action of light, including those in chronic hypoxic conditions.
Jaap, Wildeman +13 more
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Structural elements determining NAMPT activity [PDF]
, 2023 Nikotinamidadenindinukleotid (NAD) er en hydridbærer involvert i redoksreaksjoner i metabolismen. I tillegg er NAD+ et substrat av enzymer som medierer vitale NAD+-avhengige prosesser, der dinukleotidet spaltes, og frigjør en nikotinamiddel (Nam ...
Houry, Dorothée
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Oncology Reports, 2011 Nicotinamide phosphoribosyltransferase (Nampt), an enzyme involved in the NAD⁺ salvage pathway, is over-expressed and important in the carcinogenesis in several types of cancers. The expression of Nampt and its role in gastric cancer remain largely unknown. In this study, using real-time PCR and Western blotting we found that Nampt was overexpressed at
Tie-Qiang, Bi +6 more
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miR-146a impedes the anti-aging effect of AMPK via NAMPT suppression and NAD+/SIRT inactivation
Signal Transduction and Targeted Therapy, 2022 Nicotinamide adenine dinucleotide (NAD+) is indispensable for the anti-aging activity of the sirtuin (SIRT) family enzymes. AMP-activated protein kinase (AMPK) upregulates NAD+ synthesis and SIRT activity in a nicotinamide phosphoribosyltransferase ...
Hui Gong +15 more
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