Results 71 to 80 of about 634,915 (204)

Extracellular PBEF/NAMPT/visfatin activates pro-inflammatory signalling in human vascular smooth muscle cells through nicotinamide phosphoribosyltransferase activity

, 2009
Aims/hypothesis Extracellular pre-B cell colony-enhancing factor/nicotinamide phosphoribosyltransferase/visfatin (ePBEF/NAMPT/visfatin) is an adipocytokine, whose circulating levels are enhanced in metabolic disorders, such as diabetes mellitus and ...
Carraro, Raffaele, Rodríguez-Mañas, Leocadio, Sánchez-Ferrer, Carlos Félix, Matesanz, Nuria, Peiró, Concepción, Nevado, Julián, Cercas, Elena, Romacho, Tania, Azcutia Criado, Verónica, Vázquez-Bella, Marta   +9 more
core   +1 more source

Targeting metabolic vulnerability by combining NAMPT inhibitors and disulfiram for treatment of recurrent ovarian cancer

Cell Death and Disease
Ovarian cancer (OV) has the highest mortality rate among gynecological cancers. As OV progresses, tumor cells spread outside the ovaries to the peritoneal and abdominal cavities, forming cell clusters that float in the ascitic fluid caused by peritonitis
Kei Kudo, Yoshimi Endo Greer, Daniel R. Crooks, Ye Yang, Jeffrey R. Brender, Teruhiko Yoshida, Brittney S. Harrington, Rahul Kamdar, Soumya Korrapati, Yusuke Shibuya, Leah Henegar, Jeffrey Kopp, Takeo Fujii, Stanley Lipkowitz, Christina M. Annunziata   +14 more
doaj   +1 more source

Periodontitis and rheumatoid arthritis—Global efforts to untangle two complex diseases

Periodontology 2000, EarlyView.
Abstract Understanding the impact of oral health on rheumatoid arthritis (RA) will inform how best to manage patients with both periodontitis and RA. This review seeks to provide an update on interventional and mechanistic investigations, including a brief summary of European Research programs investigating the link between periodontitis and RA. Recent
Isabel Lopez‐Oliva, Jennifer Malcolm, Shauna Culshaw   +2 more
wiley   +1 more source

NAMPT enzyme activity regulates catabolic gene expression in gingival fibroblasts during periodontitis

, 2017
Periodontal disease is one of the most prevalent chronic disorders worldwide. It is accompanied by inflammation of the gingiva and destruction of periodontal tissues, leading to alveolar bone loss.
Jeong-Tae Koh, Jang-Soo Chun, Yun Hyun Huh, Lee, Gyuseok, Kook, Min-Suk, Su-Hyeon Lee, Hong, Yunkyung, Kim, Duck-Kyu, Kim, Sun-Hun, Shee Eun Lee, Park, Ka Hyon, Ka Hyon Park, Je-Hwang Ryu, Lee, Shee Eun, Sun-Hun Kim, Min-Suk Kook, Gyuseok Lee, Koh, Jeong-Tae, Chun, Jang-Soo, Duck-Kyu Kim, Huh, Yun Hyun, Ryu, Je-Hwang, Yunkyung Hong, Lee, Su-Hyeon   +23 more
core   +1 more source

A pancreatic ductal adenocarcinoma subpopulation is sensitive to FK866, an inhibitor of NAMPT

Oncotarget, 2016
Treating pancreatic cancer is extremely challenging due to multiple factors, including chemoresistance and poor disease prognosis. Chemoresistance can be explained by: the presence of a dense stromal barrier leading to a lower vascularized condition, therefore limiting drug delivery; the huge intra-tumoral heterogeneity; and the status of epithelial-to-
Barraud, Marine, Garnier, Jonathan, Loncle, Celine, Gayet, Odile, Lequeue, Charlotte, Vasseur, Sophie, Bian, Benjamin, Duconseil, Pauline, Gilabert, Marine, Bigonnet, Martin, Maignan, Aurélie, Moutardier, Vincent, Garcia, Stephane, Turrini, Olivier, Delpero, Jean-Robert, Giovannini, Marc, Grandval, Philippe, Gasmi, Mohamed, Ouaissi, Mehdi, Secq, Veronique, Poizat, Flora, Guibert, Nicolas, Iovanna, Juan, Dusetti, Nelson   +23 more
openaire   +3 more sources

Enhanced tumor suppression in patient-derived temozolomide-resistant glioblastoma cells using a combination treatment of Olaparib and FK866

BMC Cancer
Glioblastoma (GBM) is a prevalent brain cancer with notorious aggressiveness in adults. Standard treatment for GBM includes surgery, radiation, and administration of Temozolomide (TMZ).
Xiaowei Sha, Jiaqian Li, Yunlong Fang, Jingjie Feng, Yasong Feng, Jing Wang, Yang Si, Feng Li, Shan Cheng, Wei Ding   +9 more
doaj   +1 more source

Understanding exosomes in diabetic wound healing

Periodontology 2000, EarlyView.
Abstract Background Diabetic wounds signify a major complication of diabetes mellitus, characterized by chronic inflammation, compromised angiogenesis, and high risk of infection, amputation, and mortality. Contemporary therapies remain limited in efficacy and durability.
Paras Ahmad, Yulan Wang, Yufeng Zhang, Anton Sculean, Richard J. Miron   +4 more
wiley   +1 more source

Periodontitis and metabolic dysfunction‐associated steatotic liver disease

Periodontology 2000, EarlyView.
Abstract Objective Periodontitis is a chronic inflammatory disease with systemic effects that extend beyond the oral cavity and contribute to systemic immune and metabolic dysregulation. Chronic liver diseases, particularly metabolic dysfunction‐associated steatotic liver disease (MASLD) and its progressive phenotypes, have emerged as major global ...
Rafael Scaf de Molon, Erica Dorigatti de Avila, Davi da Silva Barbirato, Mariana Fampa Fogacci, Jamil Awad Shibli, Anton Sculean, Alpdogan Kantarci   +6 more
wiley   +1 more source

NAMPT Is an Essential Regulator of RA-Mediated Periodontal Inflammation

, 2017
Recent studies have indicated a potential correlation between rheumatoid arthritis (RA) and periodontal inflammation. We undertook this study to verify whether RA mediates periodontitis-like phenotypes in experimental mouse models of RA and to explore ...
S. Kim, G. Lee, J. Koh, D. Kim, Y.H. Huh, S.Y. Lee, K.H. Park, J. Ryu, J. Kim   +8 more
core   +1 more source

NAD replenishment restores mitochondrial function and thermogenesis in the brown adipose tissue of mice with obesity

The Journal of Physiology, EarlyView.
Abstract figure legend A high‐fat diet (HFD) induces brown adipose tissue (BAT) whitening, mitochondrial dysfunction (damaged cristae, fragmentation), reduced NAD+ levels and impaired thermogenesis, leading to lower energy expenditure and metabolic inflexibility.
Renata R. Braga, Matheus B. Rocha, Ana P. Morelli, Raul G. da Costa, Marcelo A. S. Mori, Adelino S. R. da Silva, José R. Pauli, Dennys E. Cintra, Eduardo R. Ropelle   +8 more
wiley   +1 more source