Results 91 to 100 of about 634,915 (204)

Ablation of NAMPT in dopaminergic neurons leads to neurodegeneration and induces Parkinson’s disease in mouse

Brain Research Bulletin
Nicotinamide phosphoribosyltransferase (NAMPT) is the key enzyme in the salvaging synthesize pathway of nicotinamide adenine dinucleotide (NAD). The neuroprotective roles of NAMPT on neurodegeneration have been explored in aging brain and Alzheimer’s ...
Cong Chen, Tong Wang, Tong-Yao Gao, Ya-Ling Chen, Yun-Bi Lu, Wei-Ping Zhang   +5 more
doaj   +1 more source

The histone deacetylase inhibitor, suberoylanilide hydroxamic acid, restores blood–brain barrier integrity in a human stem cell‐based model of ischaemic stroke

British Journal of Pharmacology, Volume 183, Issue 19, Page 5791-5812, October 2026.
Ischaemic stroke is characterised by acute cerebrovascular occlusion and blood–brain barrier (BBB) breakdown. Our results indicated that the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) ameliorated the loss of BBB integrity, changed the morphology of brain endothelial cells, increased the level of basement membrane and ...
Anikó Szecskó, Koppány Párdi, Zuhao Cui, Gergő Porkoláb, Zsófia Hoyk, Csilla Kovács, Janet F. Adegbite, Virág Fodor, Nárcisz M. Cser, László Dér, Krisztina Nagy, Csilla Sajben, Roland Tengölics, Mária A. Deli, Szilvia Veszelka   +14 more
wiley   +1 more source

NAMPT expression in PDA.

, 2019
(A) Immunoblot analysis for NAMPT in human pancreatic cancer cell lines (BxP: BxPC3, Mia: MiaPaCa2, Pan: Panc1). Note the detection of a single band for each cell line. (B) Immunohistochemical staining of NAMPT in normal pancreas (left panel) and chronic
Po Hien Ear (6444044), Kimberly L. Cramer-Morales (6444038), Ann M. Miller (6444041), Sarah L. Mott (6444035), Katelynn Davis (6444029), Carlos H. F. Chan (37435), Andrew M. Bellizzi (6444047), Craig D. Dunseth (6444032), James J. Mezhir (499018)   +8 more
core   +1 more source

ASXL1 in proinflammatory macrophages attenuates inflammatory activation and macrophage‐mediated renal tubular epithelial cell damage in acute kidney injury

Physiological Reports, Volume 14, Issue 19, October 2026.
ASXL1 in inflammatory macrophages attenuates renal tubular cell damage through coordinated histone modification of H3K27me3 and H3K4me3 in acute kidney injury. Abstract Macrophages are major contributors to inflammatory responses in acute kidney injury (AKI) and rapidly alter their gene expression through epigenetic regulation.
Yoshiyasu Ogura, Takehito Sugasawa, Masaomi Nangaku, Imari Mimura   +3 more
wiley   +1 more source

Structure-Based Identification of Ureas as Novel Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors

, 2016
Nicotinamide phosphoribosyltransferase (Nampt) is a promising anticancer target. Virtual screening identified a thiourea analogue, compound 5, as a novel highly potent Nampt inhibitor.
Geeta Sharma (1920970), Alexandre J. Buckmelter (1920976), Zhongguo Wang (1920973), Karl H. Clodfelter (5886), Dominic J. Reynolds (1920961), Kenneth W. Bair (640342), Yen-Ching Ho (640334), Janet Gunzner-Toste (1845514), Chase C. Smith (1920964), Bingsong Han (1920958), Jian Lin (323268), Angela Oh (469365), Maureen Caligiuri (1920979), Paul Bauer (1289079), Timm Baumeister (1845499), Weiru Wang (640332), Guiling Zhao (1845502), Nikolai Kley (1920967), Peter S. Dragovich (640339), Mark Zak (1845538), Xiaozhang Zheng (640341), Po-wai Yuen (1845523)   +21 more
core   +1 more source

Targeting of nicotinamide phosphoribosyltransferase enzymatic activity ameliorates lung damage induced by ischemia/reperfusion in rats

Respiratory Research, 2017
Background Emerging evidence reveals that nicotinamide phosphoribosyltransferase (NAMPT) has a significant role in the pathophysiology of the inflammatory process.
Geng-Chin Wu, Wen-I Liao, Shu-Yu Wu, Hsin-Ping Pao, Shih-En Tang, Min-Hui Li, Kun-Lun Huang, Shi-Jye Chu   +7 more
doaj   +1 more source

Small Extracellular Vesicle‐Derived Nicotinamide Phosphoribosyltransferase (NAMPT) Induces Acyl‐Coenzyme A Synthetase SLC27A4‐Mediated Glycolysis to Promote Hepatocellular Carcinoma

Journal of Extracellular Vesicles
Tumour‐derived small extracellular vesicles (sEV) are critical mediators within the tumour microenvironment (TME) and are known to regulate various metabolic pathways.
Cherlie Lot Sum Yeung, Tung Him Ng, Charlotte Jiaqi Lai, Tingmao Xue, Xiaowen Mao, Sze Keong Tey, Regina Cheuk Lam Lo, Chun‐Fung Sin, Kwan Ming Ng, Danny Ka Ho Wong, Lung‐Yi Mak, Man‐Fung Yuen, Irene Oi‐Lin Ng, Peihua Cao, Yi Gao, Jing Ping Yun, Judy Wai Ping Yam   +16 more
doaj   +1 more source

Enhancing the anticancer effect of NAMPT inhibition by targeting NAPRT in breast cancer cells

Advances in Cancer Biology - Metastasis
Introduction: Two pathways in the synthesis of NAD, catalyzed by the key enzymes nicotinamide phosphoribosyltransferase (NAMPT) and nicotinate phosphoribosyltransferase (NAPRT), support constant survival, growth, and propagation of cancer cells.
Zahra Gharedaghi, Parichehr Mehrafshar, Soha Mohammadi, Masoumeh Tavakoli-Yaraki, Pegah Golpour, Mitra Nourbakhsh, Nima Taghizadeh   +6 more
doaj   +1 more source

Discovery of a novel NAMPT inhibitor that selectively targets NAPRT-deficient EMT-subtype cancer cells and alleviates chemotherapy-induced peripheral neuropathy. [PDF]

Theranostics, 2023
Kim M, Kim H, Kang BG, Lee J, Kim T, Lee H, Jung J, Oh MJ, Seo S, Ryu MJ, Sung Y, Lee Y, Yeom J, Han G, Cha SS, Jung H, Kim HS.   +16 more
europepmc   +1 more source

Molecular Mechanisms and Insights into the Nampt Inhibitor (FK866) Resistance in Cancers [PDF]

, 2017
Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in NAD+ biosynthesis from nicotinamide, is one of the major factors regulating cell metabolism and NAMPT is considered a promising target for treating cancer.
Thongon, Natthakan
core