Results 101 to 110 of about 634,915 (204)

Effects of resveratrol on NAMPT release and NAMPT mRNA expression.

, 2014
Cells were stimulated with resveratrol in serum-free medium for 24 h. Supernatants of resveratrol treated A) HepG2 cells (n = 7) and B) primary human hepatocytes (n = 3) were used for quantifying extracellular NAMPT protein amount using a specific eNAMPT
Wieland Kiess (102793), Melanie Penke (531577), Susanne Schuster (102775), Stefanie Petzold-Quinque (531578), Antje Garten (102778), Rolf Gebhardt (89997), Georg Damm (531579), Theresa Gorski (102770)   +7 more
core   +1 more source

Stimulation of MMP-1 and CCL2 by NAMPT in PDL Cells [PDF]

, 2013
Periodontitis is an inflammatory disease caused by pathogenic microorganisms and characterized by the destruction of the periodontium. Obese individuals have an increased risk of periodontitis, and elevated circulating levels of adipokines, such as ...
Herms, Stefan, Joni Augusto Cirelli, Cirelli, Joni Augusto [UNESP], Marjan Nokhbehsaim, Nokhbehsaim, Marjan, Deschner, James, Nogueira, Andressa Vilas Boas [UNESP], Andreas Jäger, Fröhlich, Holger, Jepsen, Søren, Jäger, Andreas, Stefan Herms, James Deschner, Andressa Vilas Boas Nogueira, Sigrun Eick, Nogueira, Andressa Vilas Boas, Hoffmann, Per, Per Hoffmann, Holger Fröhlich, Søren Jepsen, Eick, Sigrun, Cirelli, Joni Augusto   +21 more
core   +2 more sources

Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors

, 2016
Crystal structures of several urea- and thiourea-derived compounds in complex with the nicotinamide phosphoribosyltransferase (Nampt) protein were utilized to design a potent amide-containing inhibitor bearing an aza-indole moiety (7, Nampt BC IC50 = 9.0
Alexandre J. Buckmelter (1920976), Zhongguo Wang (1920973), Leslie Wang (1845526), Yang Xiao (146335), Justin Ly (1728358), Dominic J. Reynolds (1920961), Yen-Ching Ho (640334), Jian Lin (323268), Thomas O’Brien (1464967), Weiru Wang (640332), Guiling Zhao (1845502), Peter S. Dragovich (640339), Po-wai Yuen (1845523), Geeta Sharma (1920970), Karl H. Clodfelter (5886), Kenneth W. Bair (640342), Janet Gunzner-Toste (1845514), Chase C. Smith (1920964), Bingsong Han (1920958), Angela Oh (469365), Maureen Caligiuri (1920979), Paul Bauer (1289079), Bianca M. Liederer (1845508), Timm Baumeister (1845499), Nikolai Kley (1920967), Mark Zak (1845538), Xiaozhang Zheng (640341)   +26 more
core   +1 more source

Grape Seed Proanthocyanidin Extract Moderated Retinal Pigment Epithelium Cellular Senescence Through NAMPT/SIRT1/NLRP3 Pathway

Journal of Inflammation Research, 2021
Wencui Wan,1,* Wei Zhu,2,* Yan Wu,3,4,* Yang Long,1 Hongzhuo Liu,1 Weiwei Wan,1 Guangming Wan,1 Jing Yu3 1Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China; 2Department ...
Zhu W, Wan W, Wu Y, Long Y, Liu H, Wan W, Wan G, Yu J   +7 more
doaj  

High NAMPT expression and anti-tumour activity of NAMPT inhibitor in adult T-cell leukemia/lymphoma

Annals of Oncology, 2019
Abstract Background Adult T-cell leukemia/lymphoma (ATL) is a malignancy of mature T lymphocytes induced by human T-cell leukemia virus-1, and has a poor outcome. New molecular targets for the prevention and treatment of ATL are urgently needed.
T. Kozako, T. Ohsugi, Y.-I. Uchida, M. Yoshimitsu, K. Ishitsuka, N. Kato, K. Sato, A. Aikawa, S.-I. Honda   +8 more
openaire   +1 more source

Integrating Pharmacogenomics Data-Driven Computational Drug Prediction with Single-Cell RNAseq to Demonstrate the Efficacy of a NAMPT Inhibitor against Aggressive, Taxane-Resistant, and Stem-like Cells in Lethal Prostate Cancer. [PDF]

Cancers (Basel), 2022
Mazumder S, Mitra Ghosh T, Mukherjee UK, Chakravarti S, Amiri F, Waliagha RS, Hemmati F, Mistriotis P, Ahmed S, Elhussin I, Salam AB, Dean-Colomb W, Yates C, Arnold RD, Mitra AK.   +14 more
europepmc   +1 more source

Nicotinamide Phosphoribosyltransferase (NAMPT) Is a New Target of Antitumor Agent Chidamide

, 2019
Chidamide is a histone deacetylase (HDAC) inhibitor that is currently used to treat cutaneous T-cell lymphoma in clinic. Herein nicotinamide phosphoribosyl­transferase (NAMPT) was identified to be a new target of chidamide on the basis of the ...
Chunquan Sheng (1364184), Ying Wu (19057), Lei Wang (6656), Shuqiang Chen (1364181), Yahui Huang (1638778), Guoqiang Dong (1364169), Shanchao Wu (1749589)   +6 more
core   +1 more source

Thiazolocarboxamide Analogues as NAMPT Inhibitors [PDF]

ACS Medicinal Chemistry Letters, 2014
Jean-Francois, Brazeau, Gerard, Rosse
openaire   +2 more sources

Exploiting Metabolic Defects in Glioma with Nanoparticle-Encapsulated NAMPT Inhibitors

Molecular Cancer Therapeutics
Abstract The treatment of primary central nervous system tumors is challenging due to the blood–brain barrier and complex mutational profiles, which is associated with low survival rates. However, recent studies have identified common mutations in gliomas [isocitrate dehydrogenase (IDH)-wild ...
Matthew A. Murray, Katelyn J. Noronha, Yazhe Wang, Anna P. Friedman, Sateja Paradkar, Hee-Won Suh, Ranjini K. Sundaram, Charles Brenner, W.M. Saltzman, Ranjit S. Bindra   +9 more
openaire   +2 more sources

Nicotinamide phosphoribosyltransferase (NAMPT) is over-expressed and abundantly released from malignant pleural mesothelioma cells becoming a potential biomarker.

Introduction Malignant pleural mesothelioma (MPM) is an aggressive and incurable cancer of the pleural surface. Chronic inflammation, oxidative stress, and persistent aberrant signaling due to asbestos exposure led to mesothelial cells transformation ...
Francesca Mazzola, Valentina Audrito, Alessia Ponzano, Santina Bruzzone, Francesco Piacente, Roberta Libener, Irene Fiorilla, Federica Grosso, Nadia Raffaelli, Alberto Maria Todesco, Enrico Moiso   +10 more
core   +1 more source