Results 121 to 130 of about 634,915 (204)

Palmatine Attenuated Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting M1 Phenotype Macrophage Polarization via NAMPT/TLR2/CCR1 Signaling

The present work was conducted to research the potential mechanism of palmatine (PAL) on lipopolysaccharide (LPS)-caused acute lung injury (ALI). Network pharmacology and bioinformatic analyses were carried out.
Lei Han (150108), Lei Wang (6656), Tong Chen (188814), Jinchun Wang (18368283)   +3 more
core   +1 more source

Treatment of Cancer with NAMPT Inhibitors [PDF]

ACS Medicinal Chemistry Letters, 2015
openaire   +2 more sources

RAS/PI3K pathway mutations sensitise epithelial ovarian cancer cells to a PARP/NAMPT inhibitor combination. [PDF]

Commun Biol
Gruet M, Xu Y, An L, Ma Y, Balcells C, Tyson K, Evangelista LC, Spear S, Xu Y, McKinney F, Babuta J, Bray C, Wickremesinghe C, Siskos AP, Nijhuis AM, Tate EW, McNeish IA, Benito A, Keun HC.   +18 more
europepmc   +2 more sources

Channeling NAMPT Ligands To Address Life and Death

Aging and age-related diseases are often associated with the breakdown of our metabolic system. NAD-metabolism maintains homeostasis by tightly regulating NAD+ and its metabolites.
Krider, Isabella Sophia
core   +4 more sources

Silibinin‐driven microbial and metabolic reprogramming restores CD4+ T cell immunity in HIV immunological nonresponders

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Despite the effectiveness of combination antiretroviral therapy (cART) in suppressing viral replication, 10%–40% of HIV‐infected individuals, characterized as immunological nonresponders (INRs), exhibit insufficient CD4⁺ T cell recovery and persistent ...
Wenli Liu, Minghui An, Qi Wang, Yuxin Shang, Shuyao Zang, Haibo Ding, Shuai Fu, Yun Liu, Xue Dong, Xiao Yang, Jinna Dai, Xiaoxu Han, Yingchun Xu, Hong Shang   +13 more
doaj   +1 more source

PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma. [PDF]

Nat Commun, 2019
Fons NR, Sundaram RK, Breuer GA, Peng S, McLean RL, Kalathil AN, Schmidt MS, Carvalho DM, Mackay A, Jones C, Carcaboso ÁM, Nazarian J, Berens ME, Brenner C, Bindra RS.   +14 more
europepmc   +1 more source

NAMPT Inhibitor OT-82 [PDF]

, 2020
openaire   +1 more source

Targeting NAD+ Metabolism Vulnerability in FH-Deficient Hereditary Leiomyomatosis and Renal Cell Carcinoma with the Novel NAMPT Inhibitor OT-82. [PDF]

Mol Cancer Ther
Najera SS, Ricketts CJ, Schmidt LS, Medina JI, Saito K, Ileva L, Brender JR, James AM, Peer CJ, Gouker B, Karim BO, Chernova O, Wells C, Wei MH, Yang Y, Zhang X, Klumpp-Thomas C, Travers J, Chen L, Wilson KM, Issaq SH, Figg WD, Difilippantonio S, Kalen JD, Krishna MC, Thomas CJ, Ceribelli M, Heske CM, Crooks DR, Meier JL.   +29 more
europepmc   +1 more source

PAK4/NAMPT Inhibitor KPT-9274 [PDF]

, 2020
openaire   +1 more source

Computational Identification of New Dual PAK4 and NAMPT Inhibitors. [PDF]

Int J Mol Sci
Wang Y, Minden A.
europepmc   +1 more source