Results 111 to 120 of about 634,915 (204)

Nampt and NMN increase NAD level and ameliorate NAD depletion.

, 2013
Human islets (A) and INS-1E cells (B) were stimulated with NMN [100 µM] or Nampt [2.5 ng/ml] for a short time (2 or 3 h) or a long time exposure (48 h). NAD level were normalised to the total protein amount in each sample. FK866 [10 nM], a specific Nampt
Annette G. Beck-Sickinger (92957), Wieland Kiess (102793), Kathrin Maedler (37711), Antje Körner (102789), Robert Spinnler (102767), Katharina Stolz (102773), Susanne Schuster (102775), Antje Garten (102778), Eelco J. P. de Koning (102785), Theresa Gorski (102770), Marten A. Engelse (102782)   +10 more
core   +1 more source

Channeling Nicotinamide Phosphoribosyltransferase (NAMPT) to Address Life and Death

Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the rate-limiting step in NAD+ biosynthesis via salvage of NAM formed from catabolism of NAD+ by proteins with NADase activity (e.g., PARPs, SIRTs, CD38).
Isabella S. Krider (14576613), Megan S. Laham (14576610), Erick T. M. Alves (18321155), Gregory R. J. Thatcher (7942685), Jenna M. Courey (17637109), Ganga Reddy Velma (18321152)   +5 more
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Nampt inhibitors evaluated for potency on mutant NAMPT enzymes.

, 2014
a) Chemical structures of NAMPT inhibitors, compound 1 is GNE-618, compound 9 is GMX1778, compound 11 is APO866. b) Fold change in IC50 of NAMPT inhibitors on purified mutant NAMPT proteins compared to wild-type enzyme.
Jiansheng Wu (193208), Yang Xiao (146335), Hong Li (20183), Kenneth W. Bair (640342), Kristi Elkins (640333), Yen-Ching Ho (640334), Mary Coons (640336), Angela Oh (469365), Lisa D. Belmont (640344), Eric Cheng (64747), Mandy Kwong (640335), Weiru Wang (640332), Lisa Crocker (640338), Thomas O'Brien (640343), Peter S. Dragovich (640339), Deepak Sampath (640340), Bobby Brillantes (640337), Xiaozhang Zheng (640341)   +17 more
core   +1 more source

NAMPT activity plays a key role in driving autoimmune processes that mediate beta-cell death and type 1 diabetes development in mice

Cell Death and Disease
Type 1 diabetes (T1D) is characterised by destruction of pancreatic beta-cells by islet-infiltrating cytotoxic lymphocytes and elevated intra-islet secretion of pro-inflammatory cytokines.
Daniel Egbase, Sophie R. Sayers, Naila Haq, Vesela S. Gesheva, Jithu J. Varghese, Sreya Bhattacharya, Jay Kynaston, Ella L. Hubber, Lorna I. F. Smith, Timothy J. Pullen, Henry Gerdes, Vivian K. Lee, David Hopkins, Min Zhao, Yee Cheah, Joshua Greally, Sam Butterworth, James A. Pearson, Gavin A. Bewick, Shanta J. Persaud, Paul W. Caton   +20 more
doaj   +1 more source

Synthesis of a C-Iminoribofuranoside Analog of the Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitor FK866

FK866 (also named APO866 or WK175) is a potent NAMPT inhibitor being evaluated (Phase II) as a potential anticancer drug. The preparation of the C-iminoribofuranoside analog (2E)-N-[4-(1-benzoylpiperidin-4-yl)butyl]-3-{3-[(2S,3S,4R,5R)-3,4-dihydroxy-5 ...
Gillig, Annabelle, Majjigapu, Somi Reddy, Sordat, Bernard, Vogel, Pierre   +3 more
core   +1 more source

ROS‐Responsive Hydrogel for Localized Delivery of Nampt and Stat3 Inhibitors Exhibits Synergistic Antitumor Effects in Colorectal Cancer Through Ferroptosis Induction and Immune Microenvironment Remodeling

Advanced Science
Targeting Nampt to modulate NAD+ metabolism and exert antitumor effects has become a research hotspot in the field of cancer metabolism. But early clinical trials have only achieved modest results, primarily due to the need for improved efficacy and the ...
Chenyang Ye, Mi Mi, Saimeng Shi, Lina Qi, Shanshan Weng, Lu Wang, Yier Lu, Chao Chen, Yinuo Tan, Mengyuan Yang, Cheng Guo, Rui Bai, Xuefeng Fang, Ji Wang, Ying Yuan   +14 more
doaj   +1 more source

Tyrosine phosphorylation and dimerization cooperatively activate NAMPT to enable NAD+ synthesis in cancer

Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in the NAD⁺ salvage pathway, is frequently upregulated in cancer, yet mechanisms regulating its catalytic activity remain undefined.
Johnvesly Basappa, Jaime L Schneider, Reza Nejati, Cosimo Lobello, Luca Mologni, Neil Sen, Kathy Q Cai, Lori Rink, Aaron N Hata, Roland Dunbrack, Joseph A Baur, Mariusz A Wasik, Li Wang, Cristina Uribe-Alvarez, Aaron R Goldman, Wujuan Zhang, Hsin-Yao Tang, David Rushmore, Jonathan Chernoff, Anneliese M Faustino, Andrey Efimov   +20 more
core   +1 more source

Anti-Cancer Activity of PAK4/NAMPT Inhibitor and Programmed Cell Death Protein-1 Antibody in Kidney Cancer. [PDF]

Kidney360, 2020
Trott JF, Aboud OA, McLaughlin B, Anderson KL, Modiano JF, Kim K, Jen KY, Senapedis W, Chang H, Landesman Y, Baloglu E, Pili R, Weiss RH.   +12 more
europepmc   +1 more source

Overall survival by NAMPT IHC score.

, 2019
Kaplan-Meier curves showing overall survival of patients with NAMPT+ (blue line) and NAMPT- (red line) PDA. Median OS: 20.4 months (NAMPT+) vs. 26.0 months (NAMPT-); P-value: 0.34.
Po Hien Ear (6444044), Kimberly L. Cramer-Morales (6444038), Ann M. Miller (6444041), Sarah L. Mott (6444035), Katelynn Davis (6444029), Carlos H. F. Chan (37435), Andrew M. Bellizzi (6444047), Craig D. Dunseth (6444032), James J. Mezhir (499018)   +8 more
core   +1 more source

Clickable prodrugs bearing potent and hydrolytically cleavable nicotinamide phosphoribosyltransferase inhibitors

Drug Design, Development and Therapy, 2018
Keivan Sadrerafi, Emilia O Mason, Mark W Lee Jr Department of Chemistry, University of Missouri, Columbia, MO, USA Purpose: Our previous study indicated that carborane containing small-molecule 1-(hydroxymethyl)-7-(4′-(trans-3″-(3‴-pyridyl ...
Sadrerafi K, Mason EO, Lee Jr MW
doaj