Results 101 to 110 of about 19,829 (313)

Study of the effect of codon optimization on Anti-VEGF nanobody expression [PDF]

مجله بیوتکنولوژی کشاورزی, 2018
Plants can be exploited for the production of various recombinant proteins as valuable bioreactors because of many reasons. The use of plant viral vectors for the transient expression offers as a useful strategy for the large-scale production of proteins
Mozhgan Soleymanizadeh, Abdolreza Bagheri, Mokhtar Jalai, Alireza Seyfi, Mahdi Behdani, Fatemeh Kazemi   +5 more
doaj   +1 more source

Production of Potyvirus-Derived Nanoparticles Decorated with a Nanobody in Biofactory Plants

Frontiers in Bioengineering and Biotechnology, 2022
Viral nanoparticles (VNPs) have recently attracted attention for their use as building blocks for novel materials to support a range of functions of potential interest in nanotechnology and medicine.
Maricarmen Martí, Fernando Merwaiss, Anamarija Butković, José-Antonio Daròs   +3 more
doaj   +1 more source

A novel anti-CTLA-4 nanobody-IL12 fusion protein in combination with a dendritic cell/tumour fusion cell vaccine enhances the antitumour activity of CD8+ T cells in solid tumours

Journal of Nanobiotechnology
Background We previously developed a nanobody targeting CTLA-4 and demonstrated that it can boost antitumour T-cell responses in vitro; however, the resulting responses after the injection of T cells into cancer models are usually weak and transient ...
Meng-jie Jiang, Hao-peng Cui, Ting-ting Li, Xiao-mei Yang, Xiao-ling Lu, Ai-qun Liu   +5 more
doaj   +1 more source

Targeting multiple myeloma with nanobody-based heavy chain antibodies, bispecific killer cell engagers, chimeric antigen receptors, and nanobody-displaying AAV vectors

Frontiers in Immunology, 2022
Nanobodies are well suited for constructing biologics due to their high solubility. We generated nanobodies directed against CD38, a tumor marker that is overexpressed by multiple myeloma and other hematological malignancies.
Julia Hambach, Julia Hambach, Anna Marei Mann, Peter Bannas, Friedrich Koch-Nolte   +4 more
doaj   +1 more source

Research progress and applications of nanobody in human infectious diseases

Frontiers in Pharmacology, 2022
Infectious diseases, caused by pathogenic microorganisms, are capable of affecting crises. In addition to persistent infectious diseases such as malaria and dengue fever, the vicious outbreaks of infectious diseases such as Neocon, Ebola and SARS-CoV-2 ...
Yaxian Mei, Yuanzhi Chen, Jwala Sivaccumar, Z. An, N. Xia, Wen-xin Luo   +5 more
semanticscholar   +1 more source

The Molecular Toolbox for Linkage Type‐Specific Analysis of Ubiquitin Signaling

ChemBioChem, Accepted Article.
Modification of proteins and other biomolecules with ubiquitin regulates virtually all aspects of eukaryotic cell biology. Ubiquitin can be attached to substrates as a monomer or as an array of polyubiquitin chains with defined linkages between the ubiquitin moieties.
Julian Koch, Camilla Reiter Elbæk, Dominik Priesmann, Rune Busk Damgaard   +3 more
wiley   +1 more source

Immune cell landscapes are associated with high-grade serous ovarian cancer survival

Scientific Reports
High-grade serous ovarian cancer (HGSOC) is an aggressive disease known to develop resistance to chemotherapy. We investigated the prognostic significance of tumor cell states and potential mechanisms underlying chemotherapy resistance in HGSOC ...
Guoan Zhang, Yan Zhang, Jingjing Zhang, Xiaohui Yang, Wenjie Sun, Ying Liu, Yingfu Liu   +6 more
doaj   +1 more source

Development of novel-nanobody-based lateral-flow immunochromatographic strip test for rapid detection of recombinant human interferon α2b

Journal of Pharmaceutical Analysis, 2022
Recombinant human interferon α2b (rhIFNα2b) is widely used as an antiviral therapy agent for the treatment of hepatitis B and hepatitis C. The current identification test for rhIFNα2b is complex.
Xi Qin, Maoqin Duan, Dening Pei, Jian Lin, Lan Wang, Peng Zhou, Wenrong Yao, Ying Guo, Xiang Li, Lei Tao, Youxue Ding, Lan Liu, Yong Zhou, Chuncui Jia, Chunming Rao, Junzhi Wang   +15 more
doaj  

A CTLA-4 blocking strategy based on Nanoboby in dendritic cell-stimulated cytokine-induced killer cells enhances their anti-tumor effects

BMC Cancer, 2021
Background Cytokine-induced killer cells induced with tumor antigen-pulsed dendritic cells (DC-CIK) immunotherapy is a promising strategy for the treatment of malignant tumors. However, itsefficacy isrestricted by the immunosuppression, which is mediated
Wu Wang, Xi Wang, Wenli Yang, Kai Zhong, Na He, Xuexia Li, Yanyang Pang, Zi Lu, Aiqun Liu, Xiaoling Lu   +9 more
doaj   +1 more source

Discovery of Nanosota-2, -3, and -4 as super potent and broad-spectrum therapeutic nanobody candidates against COVID-19

Journal of Virology, 2023
Nanobodies are single-domain antibodies derived from camelid animals. Here, we discovered three anti-SARS-CoV-2 nanobodies, namely, Nanosota-2, -3, and -4, from an alpaca immunized with SARS-CoV spike protein.
G. Ye, Ruangang Pan, Fan Bu, Jian Zheng, Alise Mendoza, Wei Wen, Lanying Du, Benjamin Spiller, Brian E. Wadzinski, Bin Liu, Stanley Perlman, Fang Li   +11 more
semanticscholar   +1 more source