Results 101 to 110 of about 16,593 (260)

The molecular basis of ligand interaction at free fatty acid receptor 4 (FFA4/GPR120) [PDF]

, 2014
The long-chain fatty acid receptor FFA4(previously GPR120) is receiving substantial interest as a novel target for the treatment of metabolic and inflammatory disease.
Hudson, Brian D., Milligan, Graeme, Shimpukade, Bharat, Ulven, Trond   +3 more
core   +1 more source

Antibody‐Empowered Nanomedicine for Precise Biomedical Applications

Advanced Science, EarlyView.
This review explores strategies for functionalizing nanoparticles with antibodies to construct antibody‐empowered nanomedicine. It discusses the classification of these nanomedicines based on antibody structure, with a specific focus on their biomedical applications in diagnostics, bioimaging, and therapeutics for various diseases.
Chen Chen, Xinglin Chen, Zhenhao Gao, Meng Sun, Yaozong Yu, Fang Lv, Qiujun Wang, Jinfeng Zhang   +7 more
wiley   +1 more source

NanoBinder: a machine learning assisted nanobody binding prediction tool using Rosetta energy scores

Journal of Cheminformatics
Nanobodies offer significant therapeutic potential due to their small size, stability, and versatility. Although advancements in computational protein design have made designing de novo nanobodies increasingly feasible, there are limited tools ...
Palistha Shrestha, Chandana S. Talwar, Jeevan Kandel, Kwang-Hyun Park, Kil To Chong, Eui-Jeon Woo, Hilal Tayara   +6 more
doaj   +1 more source

The anti-tumor activity of a neutralizing nanobody targeting leptin receptor in a mouse model of melanoma.

PLoS ONE, 2014
Environmental and genetic activation of a brain-adipocyte axis inhibits cancer progression. Leptin is the primary peripheral mediator of this anticancer effect in a mouse model of melanoma.
Travis McMurphy, Run Xiao, Daniel Magee, Andrew Slater, Lennart Zabeau, Jan Tavernier, Lei Cao   +6 more
doaj   +1 more source

Spontaneous emission rate of an excited atom placed near a nanofiber

, 2002
The spontaneous decay rates of an excited atom placed near a dielectric cylinder are investigated. A special attention is paid to the case when the cylinder radius is small in comparison with radiation wavelength (nanofiber or photonic wire).
't Hooft, Braginsky, Braginsky, Bykov, Chance, Chew, Collot, Fermi, Goy, Jhe, John, Klimov, Klimov, Klimov, Kocharovsky, Lagarkov, Lin, Mie, Pendry, Purcell, Sandoghdar, Shelby, Shelby, Smith, Smith, V.V. Klimov, Veselago, Yablonovich   +27 more
core   +1 more source

Advances in targeted degradation of endogenous proteins [PDF]

, 2019
Protein silencing is often employed as a means to aid investigations in protein function and is increasingly desired as a therapeutic approach. Several types of protein silencing methodologies have been developed, including targeting the encoding genes ...
Fulcher, Luke, Roth, Sascha, Sapkota, Gopal   +2 more
core   +2 more sources

Engineered CAR‐NKT Extracellular Vesicles Suppress Tumor Progression and Enhance Antitumor Immunity

Advanced Science, EarlyView.
TM4SF1‐nanobody engineered CAR‐natural killer T–derived extracellular vesicles (CARTM4SF1‐EVs) provide a cell‐free alternative to CAR‐NKT therapy, achieving potent, targeted antitumor activity with reduced toxicity. CARTM4SF1‐EVs induce immunogenic cell death, remodel the tumor microenvironment, and enhance CD8⁺ T‐cell antitumor immunity.
Xiaopei Hao, Chengming Qu, Yanzhao Zhou, Xiaoqian Wang, Xiangjun Qian, Xun Chen, Feng Han, Xiaokai Zhang, Yiyi Ji, Han Li, ChengWei Ju, Peng Xia, Weiwei Tang, Hao Zhuang, Jinxue Zhou   +14 more
wiley   +1 more source

Innovative CDR grafting and computational methods for PD-1 specific nanobody design

Frontiers in Bioinformatics
IntroductionThe development of nanobodies targeting Programmed Cell Death Protein-1 (PD-1) offers a promising approach in cancer immunotherapy. This study aims to design and characterize a PD-1-specific nanobody using an integrated computational and ...
Jagadeeswara Reddy Devasani, Girijasankar Guntuku, Nalini Panatula, Murali Krishna Kumar Muthyala, Mary Sulakshana Palla, Teruna J. Siahaan   +5 more
doaj   +1 more source

Screening and activity identification of an anti-idiotype nanobody for Bt Cry1F toxin from the camelid naive antibody phage display library

Food and Agricultural Immunology, 2020
Anti-idiotypic antibody technology has been widely developed. Here, we prepared the F(ab’)2 fragments of the Cry1F toxin polyclonal antibody as Ab1and screened an anti-idiotype nanobody (VHH) for Bt Cry1F toxin from the camelid naive antibody phage ...
Jia Hao, Yihang Li, Jingxuan Wang, Chongxin Xu, Meijing Gao, Wei Chen, Xiao Zhang, Xiaodan Hu, Yuan Liu, Xianjin Liu   +9 more
doaj   +1 more source

Targeting endogenous proteins for degradation through the affinity-directed protein missile system [PDF]

, 2017
Targeted proteolysis of endogenous proteins is desirable as a research toolkit and in therapeutics. CRISPR/Cas9-mediated gene knockouts are irreversible and often not feasible for many genes.
Fulcher, Luke J., Hutchinson, Luke D., Macartney, Thomas J., Sapkota, Gopal P., Turnbull, Craig   +4 more
core   +2 more sources