Results 111 to 120 of about 19,829 (313)
Label‐Free Photonic Biosensors: Key Technologies for Precision Diagnostics
ChemistryEurope, EarlyView.Photonic biosensors are versatile technologies promising unique advantages to improve current diagnosis workflows. On‐going research is directed to systems integration and automation as well as enhancing assay performance. Advances in bioengineering, material sciences, and photonics engineering will be the key toward their eventual implementation as ...
Maria Soler, Laura M. Lechuga
wiley +1 more source
Nanobodies for the Early Detection of Ovarian Cancer
International Journal of Molecular Sciences, 2022 Ovarian cancer ranks fifth in cancer-related deaths among women. Since ovarian cancer patients are often asymptomatic, most patients are diagnosed only at an advanced stage of disease. This results in a 5-year survival rate below 50%, which is in strong contrast to a survival rate as high as 94% if detected and treated at an early stage.
Lan-Huong Tran +8 more
openaire +5 more sources
Nanosecond Hyperquenching for Electron Cryo‐Microscopy Without Air‐Water Interface Artifacts
Chemistry – A European Journal, EarlyView.A novel method for the ultrafast vitrification of the biological assemblies is assayed by the electron cryotomography. Protein specimens prepared by this method inherently lack the spatial/structural artifacts, which derive from the surface tension at the air‐water interface (AWI).
Utz H. Ermel +2 more
wiley +1 more source
Nanobodies: A Review of Generation, Diagnostics and Therapeutics.
International journal of molecular sciences, 2023 Nanobodies, also referred to as single domain-based VHHs, are antibody fragments derived from heavy-chain only IgG antibodies found in the Camelidae family. Due to their small size, simple structure, high antigen binding affinity, and remarkable stability in extreme conditions, nanobodies possess the potential to overcome several of the limitations of ...
Jin, Bo-Kyung +3 more
openaire +3 more sources
Rapid Delivery of Nanobodies/VHHs into Living Cells via Expressing In Vitro-Transcribed mRNA
Molecular Therapy: Methods & Clinical Development, 2020 Intracellular antigen labeling and manipulation by antibodies have been long-thought goals in the field of cell research and therapy. However, a central limitation for this application is that antibodies are not able to penetrate into the cytosol of ...
Xuechen Zhou +6 more
doaj
Identification and in vivo characterization of a brain-penetrating nanobody
Fluids and Barriers of the CNS, 2020 Background Preclinical models to determine blood to brain transport ability of therapeutics are often ambiguous. In this study a method is developed that relies on CNS target-engagement and is able to rank brain-penetrating capacities. This method led to
Y Wouters +3 more
doaj +1 more source
Methods for the Generation of Single‐Payload Antibody‐Drug Conjugates
ChemMedChem, EarlyView.Antibody‐drug conjugates (ADCs) have emerged as a powerful form of targeted therapeutic. However, despite the myriad methods to generate even‐integer drug‐to‐antibody ratio (DAR) ADCs, strategies to generate DAR 1 are seldom reported despite the property tuning advantages of low drug loading or in enabling access to antibody‐protein constructs.
Thomas Wharton, David R. Spring
wiley +1 more source
Research Advances on Identification and Detection Methods for Aflatoxigenic Fungi
Food Frontiers, EarlyView.The recent advances on identification and determination methods for aflatoxigenic fungi were summarized. The challenges and research trends for rapid and sensitive identification and detection of aflatoxigenic fungi in the future were also well‐discussed.
Qingyu Shang +5 more
wiley +1 more source
Novel Therapy Based on Camelid Nanobodies [PDF]
Therapeutic Delivery, 2013 Nanobodies (Nbs) are small antibody fragments derived from camelid heavy chain antibodies through recombinant gene technology. Their exceptional physicochemical properties, possibility of humanization and unique antigen recognition properties make them excellent candidates for targeted delivery of biologically active components.
Miguel Soriano +5 more
openaire +5 more sources
AGuIX nanoparticle-nanobody bioconjugates to target immune checkpoint receptors [PDF]
Comparison of click chemistry and sortagging grafting strategies for functionalizing AGuIX nanoparticles with nanobodies to develop a tri-functional technology combining MRI imaging, radiotherapy, and immunotherapy by inhibiting immune checkpoints.
arxiv +1 more source