In planta expression of nanobody-based designer chicken antibodies targeting Campylobacter [PDF]
, 2018 Campylobacteriosis is a widespread infectious disease, leading to a major health and economic burden. Chickens are considered as the most common infection source for humans. Campylobacter mainly multiplies in the mucus layer of their caeca.
De Greve, Henri +11 more
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Production of a mono-biotinylated EGFR nanobody in the E. coli periplasm using the pET22b vector
BMC Research Notes, 2018 Objective Our aim was to produce a mono-biotinylated single domain antibody (‘nanobody’) specific for the epidermal growth factor receptor (EGFR), which is overexpressed in many cancer cells.
Alfiah Noor +7 more
doaj +1 more source
Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor. [PDF]
, 2018 The intrinsic efficacy of orthosteric ligands acting at G-protein-coupled receptors (GPCRs) reflects their ability to stabilize active receptor states (R*) and is a major determinant of their physiological effects.
Livingston, Kathryn E +4 more
core
A specific nanobody prevents amyloidogenesis of D76N \u3b22-microglobulin in vitro and modifies its tissue distribution in vivo [PDF]
, 2017 Systemic amyloidosis is caused by misfolding and aggregation of globular proteins in vivo for which effective treatments are urgently needed. Inhibition of protein self-aggregation represents an attractive therapeutic strategy.
Ballico, Maurizio +25 more
core +1 more source
Bypassing the Need for Cell Permeabilization: Nanobody CDR3 Peptide Improves Binding on Living Bacteria [PDF]
, 2023 Anke Breine +9 more
openalex +1 more source
Preparation of a Nanobody Specific to Dectin 1 and Its Anti-inflammatory Effects on Fungal Keratitis
International Journal of Nanomedicine, 2022 Xing Liu,1 Jianxin Sui,2 Cui Li,1 Xudong Peng,1 Qian Wang,1 Nan Jiang,1 Qiang Xu,1 Luokai Wang,2 Jing Lin,1 Guiqiu Zhao1 1Department of Ophthalmology, Affiliated Hospital of Qingdao University, Qingdao, People’s Republic of China; 2College of Food ...
Liu X +9 more
doaj
Molecules, 2019 Despite the advantages of the nanobody, the unique structure limits its use in sandwich immunoassay. In this study, a facile protocol of sandwich immunoassay using the nanobody was established.
Li Xu +3 more
doaj +1 more source
Active state structures of G protein-coupled receptors highlight the similarities and differences in the G protein and arrestin coupling interfaces [PDF]
, 2017 G protein-coupled receptors (GPCRs) regulate cellular signalling through heterotrimeric G proteins and arrestins in response to an array of extracellular stimuli.
Carpenter, Byron, Tate, Christopher G.
core +1 more source
Nanobody-based bispecific T-cell engager (Nb-BiTE): a new platform for enhanced T-cell immunotherapy
Signal Transduction and Targeted Therapy, 2023 Xiao-mei Yang +9 more
doaj +1 more source
A method for rapid nanobody screening with no bias of the library diversity
iScienceSummary: Nanobody, referred to the variable domain of heavy-chain-only antibodies, has several advantages such as small size and feasible Escherichia coli expression, making them promising for scientific research and therapies.
Zhiqing Tao +12 more
doaj +1 more source