Results 141 to 150 of about 16,593 (260)

A Nanobody‐on‐Quantum Dot Displacement Assay for Rapid and Sensitive Quantification of the Epidermal Growth Factor Receptor (EGFR) [PDF]

, 2022
Ruifang Su, Yu‐Tang Wu, Sofia Doulkeridou, Xue Qiu, Thomas Just Sørensen, Kimihiro Susumu, Igor L. Medintz, Paul M.P. van Bergen en Henegouwen, Niko Hildebrandt   +8 more
openalex   +1 more source

Light‐Based Molecular Tools to Precisely Monitor and Operate β‐Adrenoceptors

Medicinal Research Reviews, EarlyView.
ABSTRACT β‐Adrenoceptors are important G protein–coupled receptors involved in cardiovascular, metabolic, and neurological regulation. To study their function with high precision, light‐based molecular tools have been developed offering precise spatiotemporal control.
Ignazzitto Maria Tindara, Gómez‐Santacana Xavier, Llebaria Amadeu, Rovira Xavier   +3 more
wiley   +1 more source

Proteasome-targeted nanobodies alleviate pathology and functional decline in an α-synuclein-based Parkinson’s disease model [PDF]

, 2018
Diptaman Chatterjee, Mansi A. Bhatt, David Butler, Erwin De Genst, Christopher M. Dobson, Anne Messer, Jeffrey H. Kordower   +6 more
openalex   +1 more source

Development of Multivalent Nanobodies Blocking SARS CoV 2 Infection by Targeting RBD of Spike Protein [PDF]

, 2020
Qizhong Lu, Zongliang Zhang, Hexian Li, Kunhong Zhong, Qin Zhao, Zeng Wang, Zhiguo Wu, Donghui Yang, Shuang Sun, Nian Yang, Meijun Zheng, Shasha Zhao, Cheng Long, Wenhao Guo, Hui Yang, Chunlai Nie, Aiping Tong   +16 more
openalex   +1 more source

SARS-CoV-2 nanobodies 2.0 [PDF]

Signal Transduction and Targeted Therapy, 2021
Fabien Labroussaa, Joerg Jores
openaire   +4 more sources

Integrative Modeling in the Age of Machine Learning: A Summary of HADDOCK Strategies in CAPRI Rounds 47–55

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The HADDOCK team participated in CAPRI rounds 47–55 as server, manual predictor, and scorers. Throughout these CAPRI rounds, we used a plethora of computational strategies to predict the structure of protein complexes. Of the 10 targets comprising 24 interfaces, we achieved acceptable or better models for 3 targets in the human category and 1 ...
Victor Reys, Marco Giulini, Vlad Cojocaru, Anna Engel, Xiaotong Xu, Jorge Roel‐Touris, Cunliang Geng, Francesco Ambrosetti, Brian Jiménez‐García, Zuzana Jandova, Panagiotis I. Koukos, Charlotte van Noort, João M. C. Teixeira, Siri C. van Keulen, Manon Réau, Rodrigo V. Honorato, Alexandre M. J. J. Bonvin   +16 more
wiley   +1 more source

Nanobodies raised against monomeric alpha-synuclein inhibit fibril formation and destabilize toxic oligomeric species [PDF]

, 2017
BACKGROUND: The aggregation of the protein ɑ-synuclein (ɑS) underlies a range of increasingly common neurodegenerative disorders including Parkinson’s disease.
Bryant, CE, Buell, AK, Choi, ML, De Genst, E, Dobson, CM, Gandhi, S, Guilliams, T, Hong, L, Horrocks, MH, Hughes, CD, Iljina, M, Klenerman, D, Knowles, TPJ, Lee, J-E, Lee, SF, Ludtmann, MH, Ruggeri, FS, Vendruscolo, M   +17 more
core  

An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike

, 2020
Michael Schoof, Bryan Faust, Reuben A. Saunders, Smriti Sangwan, Veronica V. Rezelj, Nick Hoppe, Morgane Boone, Christian B. Billesbølle, Cristina Puchades, Caleigh M. Azumaya, Huong T. Kratochvil, Marcell Zimanyi, Ishan Deshpande, Jiahao Liang, Sasha Dickinson, Henry C. Nguyen, Cynthia M. Chio, Gregory E. Merz, Michael C. Thompson, Devan Diwanji, Kaitlin Schaefer, Aditya Anand, Niv Dobzinski, Beth Shoshana Zha, Camille R. Simoneau, Kristoffer E. Leon, Kris M. White, Un Seng Chio, Meghna Gupta, Mingliang Jin, Fei Li, Yanxin Liu, Kaihua Zhang, David Bulkley, Ming Sun, Amber M. Smith, Alexandrea N. Rizo, Frank R. Moss, Axel F. Brilot, Sergei Pourmal, Raphael Trenker, Thomas H. Pospiech, Sayan Gupta, Benjamin Barsi‐Rhyne, Vladislav Belyy, Andrew W. Barile-Hill, Silke Nock, Yuwei Liu, Nevan J. Krogan, Corie Y. Ralston, Danielle L. Swaney, Adolfo Garcı́a-Sastre, Mélanie Ott, Marco Vignuzzi, Peter Walter, Aashish Manglik, Caleigh M. Azumaya, Cristina Puchades, Ming Sun, Julian R. Braxton, Axel F. Brilot, Meghna Gupta, Fei Li, Kyle E. Lopez, Arthur A. Melo, Gregory E. Merz, Frank R. Moss, Joana Paulino, Thomas H. Pospiech, Sergei Pourmal, Alexandrea N. Rizo, Amber M. Smith, Paul V. Thomas, Feng Wang, Zanlin Yu, Miles Sasha Dickinson, Henry C. Nguyen, Daniel Asarnow, Melody G. Campbell, Cynthia M. Chio, Un Seng Chio, Devan Diwanji, Bryan Faust, Meghna Gupta, Nick Hoppe, Mingliang Jin, Junrui Li, Yanxin Liu, Gregory E. Merz, Smriti Sangwan, Tsz Kin Martin Tsui, Raphael Trenker, Donovan Trinidad, Eric Tse, Kaihua Zhang, Fengbo Zhou, Nadia Herrera, Huong T. Kratochvil, Ursula Schulze‐Gahmen, Michael C. Thompson   +99 more
openalex   +1 more source

Inhalable Nanobody (PiN-21) prevents and treats SARS-CoV-2 infections in Syrian hamsters at ultra-low doses [PDF]

, 2021
Sham Nambulli, Yufei Xiang, Natasha L. Tilston‐Lunel, Linda J. Rennick, Zhe Sang, William B. Klimstra, Douglas S. Reed, Nicholas A. Crossland, Yi Shi, W. Paul Duprex   +9 more
openalex   +1 more source

Selection of Functional Intracellular Nanobodies

SLAS Discovery, 2019
Camelid-derived nanobodies are versatile tools for research, diagnostics, and therapeutics. Certain nanobodies can function as intrabodies and bind antigens within the eukaryotic cytosol. This capability is valuable for the development of intracellular probes and targeted gene therapies.
openaire   +2 more sources