Results 141 to 150 of about 19,829 (313)
Preparation of a Nanobody Specific to Dectin 1 and Its Anti-inflammatory Effects on Fungal Keratitis
International Journal of Nanomedicine, 2022 Xing Liu,1 Jianxin Sui,2 Cui Li,1 Xudong Peng,1 Qian Wang,1 Nan Jiang,1 Qiang Xu,1 Luokai Wang,2 Jing Lin,1 Guiqiu Zhao1 1Department of Ophthalmology, Affiliated Hospital of Qingdao University, Qingdao, People’s Republic of China; 2College of Food ...
Liu X +9 more
doaj
Imaging Ligand‐Receptor Interactions at Single‐Protein Resolution with DNA‐PAINT
Small Methods, EarlyView.A labeling approach for small ligands in DNA‐PAINT super‐resolution microscopy preserving ligand functionality is demonstrated. This method enables the study of ligand‐receptor interactions at single‐protein resolution providing detailed insights into their spatial arrangement and interactions. Here, the interaction of the Epidermal Growth Factor (EGF)
Monique Honsa +8 more
wiley +1 more source
A Novel Anti-CD47 Nanobody Tetramer for Cancer Therapy
AntibodiesCD47 acts as a defense mechanism for tumor cells by sending a “don’t eat me” signal via its bond with SIRPα. With CD47’s overexpression linked to poor cancer outcomes, its pathway has become a target in cancer immunotherapy.
Nataliya M. Ratnikova +5 more
doaj +1 more source
Molecules, 2019 Despite the advantages of the nanobody, the unique structure limits its use in sandwich immunoassay. In this study, a facile protocol of sandwich immunoassay using the nanobody was established.
Li Xu +3 more
doaj +1 more source
Nectin4‐targeted molecular imaging in solid tumors: Current status and future perspectives
VIEW, EarlyView.In this review, we provide a concise overview of the mechanisms by which Nectin4 contributes to the pathogenesis of various malignancies and detail the classes of Nectin4‐targeted molecular probes. We then delve into the significant advancements in Nectin4‐targeted molecular imaging techniques, encompassing both nuclear medicine and optical imaging ...
Yongshun Liu +6 more
wiley +1 more source
Nanobody-based bispecific T-cell engager (Nb-BiTE): a new platform for enhanced T-cell immunotherapy
Signal Transduction and Targeted Therapy, 2023 Xiao-mei Yang +9 more
doaj +1 more source
Head‐To‐Head Comparison of Biologic Efficacy in Asthma: What Have We Learned?
Allergy, EarlyView.ABSTRACT We performed an in‐depth appraisal of indirect head‐to‐head comparisons of biologics approved for asthma, including anti‐IL5/5Rα (mepolizumab, benralizumab), anti‐IL4Rα (dupilumab), anti‐TSLP (tezepelumab) and anti‐IgE (omalizumab), which was neither a systematic review nor a meta‐analysis.
Brian J. Lipworth +4 more
wiley +1 more source
Selection of Functional Intracellular Nanobodies
SLAS Discovery, 2019 Camelid-derived nanobodies are versatile tools for research, diagnostics, and therapeutics. Certain nanobodies can function as intrabodies and bind antigens within the eukaryotic cytosol. This capability is valuable for the development of intracellular probes and targeted gene therapies.
openaire +2 more sources
In Vitro Self-assembly Study of ZEN/DON Anti-idiotype Nanobody Based on SpyCatcher/SpyTag
Shipin gongye ke-jiTo improve the immunoassay performance of mycotoxin anti-idiotype nanobody and to realize mimicry of bispecific detected antigens, in this study, anti-idiotype nanobody against zearalenone (ZEN) and deoxynivalenol (DON) were used, and the SpyCatcher ...
Xiao WU +5 more
doaj +1 more source