Results 161 to 170 of about 19,829 (313)

Invention, Innovation, and Commercialisation in British Biophysics [PDF]

arXiv
British biophysics has a rich tradition of scientific invention and innovation, on several occasions resulting in new technologies which have transformed biological insight, such as rapid DNA sequencing, high-precision super-resolution and label-free microscopy hardware, new approaches for high-throughput and single-molecule bio-sensing, and the ...
arxiv  

Imaging malaria parasites across scales and time

Journal of Microscopy, EarlyView.
Abstract The idea that disease is caused at the cellular level is so fundamental to us that we might forget the critical role microscopy played in generating and developing this insight. Visually identifying diseased or infected cells lays the foundation for any effort to curb human pathology.
Julien Guizetti
wiley   +1 more source

Sequence-Augmented SE(3)-Flow Matching For Conditional Protein Backbone Generation [PDF]

arXiv
Proteins are essential for almost all biological processes and derive their diverse functions from complex 3D structures, which are in turn determined by their amino acid sequences. In this paper, we exploit the rich biological inductive bias of amino acid sequences and introduce FoldFlow-2, a novel sequence-conditioned SE(3)-equivariant flow matching ...
arxiv  

Direct Stimulation of Gastric Smooth Muscle Cells via Gq Proteins With Light

Neurogastroenterology &Motility, EarlyView.
Optogenetic stimulation enables direct and selective stimulation of smooth muscle cells and thus provides a new opportunity to restore gastric contractility in cases of gastroparesis. Herein, we demonstrate that hOPN5 is a new and effective tool acting via Gq signaling and is thus complementary to light‐induced membrane depolarization with ...
David Zipf, Markus Vogt, Udhayabhaskar Sathyanarayanan, Ahmed Wagdi, Johannes Riebeling, Robert Patejdl, Tobias Bruegmann   +6 more
wiley   +1 more source

Development of nanobodies targeting hepatocellular carcinoma and application of nanobody-based CAR-T technology

Journal of Translational Medicine
Abstract Background Chimeric antigen receptor T (CAR-T) cell therapy, as an emerging anti-tumor treatment, has garnered extensive attention in the study of targeted therapy of multiple tumor-associated antigens in hepatocellular carcinoma (HCC).
Keming Lin, Baijin Xia, Xuemei Wang, Xin He, Mo Zhou, Yingtong Lin, Yidan Qiao, Rong Li, Qier Chen, Yuzhuang Li, Jinzhu Feng, Tao Chen, Cancan Chen, Xinyu Li, Hui Zhang, Lijuan Lu, Bingfeng Liu, Xu Zhang   +17 more
openaire   +3 more sources

Generation and characterization of non-competitive furin-inhibiting nanobodies [PDF]

, 2012
Jingjing Zhu, Jeroen Declercq, Bart Roucourt, Gholamreza Hassanzadeh Ghassabeh, Sandra Meulemans, Jörg Kinne, Guido David, A.J.M. Vermorken, Wim J.M. Van de Ven, Iris Lindberg, Serge Muyldermans, John W.M. Creemers   +11 more
openalex   +1 more source

Ablynx drops lead nanobody [PDF]

, 2012
Gunjan Sinha
openalex   +1 more source

Identification of potential cell surface targets in patient‐derived cultures toward photoimmunotherapy of high‐grade serous ovarian cancer

Photochemistry and Photobiology, EarlyView.
Through mRNA sequencing, proteomics, and flow cytometry, we identified potential cell surface targets toward tumor‐targeted, activatable photoimmunotherapy (taPIT) in advanced high‐grade serous ovarian cancers (HGSOCs) with low EGFR expression. The reliance on EGFR overexpression has been a major limitation of taPIT, which this study seeks to address ...
Sudip Timilsina, Anish Raju Amara, Rafay Abu, Bryan Q. Spring   +3 more
wiley   +1 more source

Neutralizing Nanobodies Targeting Diverse Chemokines Effectively Inhibit Chemokine Function [PDF]

, 2013
Christophe Blanchetot, Dennis Verzijl, Azra Mujić-Delić, Leontien Bosch, Louise Rem, Rob Leurs, C. Theo Verrips, Michael Saunders, Hans de Haard, Martine J. Smit   +9 more
openalex   +1 more source

Recent advances in the structure, function and regulation of the volume‐regulated anion channels and their role in immunity

The Journal of Physiology, EarlyView.
Abstract figure legend The volume‐regulated anion channel (VRAC), composed of leucine‐rich repeat‐containing 8 (LRRC8) proteins, serves both canonical and non‐canonical functions in vertebrate cells. The canonical function of this channel relates to its original description, which is homeostatic regulation of cell volume in response to hypotonic ...
Sergei Yanushkevich, Aleksandra Zieminska, Joshua Gonzalez, Francisca Añazco, Richard Song, Alejandra Arias‐Cavieres, Sara T. Granados, Junyi Zou, Yan Rao, Axel R. Concepcion   +9 more
wiley   +1 more source