Results 161 to 170 of about 16,593 (260)
Structural basis of a novel PD-L1 nanobody for immune checkpoint blockade [PDF]
, 2017 Fei Zhang +10 more
openalex +1 more source
Modulating ion channels with nanobodies
Synthetic and Systems BiotechnologyIon channels play instrumental roles in regulating membrane potential and cross-membrane signal transduction, thus making them attractive targets for understanding various physiological processes and associated diseases. Gaining a deeper understanding of their structural and functional properties has significant implications for developing therapeutic ...
Sher Ali +3 more
openaire +3 more sources
Recent Progress in the Development of Metal‐Based Radiosensitizations for Cancer Therapy: A Review
Rare Metals, EarlyView.ABSTRACT Radiotherapy (RT) remains an indispensable means in cancer treatment; however, its therapeutic efficacy is often limited by tumor radioresistance and side effect of damage to healthy tissue. The advances in nanotechnology have propelled metal radiosensitizers to forefront of precision medicine.
Xiao‐Xia Wu +12 more
wiley +1 more source
Recent Advances in Bioconjugation of Aromatic Amino Acid Residues by a Reactivity‐Guided Approach
The Chemical Record, EarlyView.This review highlights recent advances in the bioconjugation of aromatic amino acids residues, focusing on strategies that leverage their inherent chemical reactivity to enable precise and versatile modifications of biomacromolecules, illustrating relevant applications.
Bruno M. da S. Santos +3 more
wiley +1 more source
A novel bispecific nanobody protects mice against RSV infection via intranasal administration
Journal of VirologyRespiratory syncytial virus (RSV) is the leading cause of respiratory infection-related hospitalizations in children younger than 5 years. Neutralizing nanobody-based interventions represent a promising strategy against RSV.
Min Zhang +6 more
doaj +1 more source
Permeability of the Blood-Brain Barrier and Transport of Nanobodies Across the Blood-Brain Barrier [PDF]
, 2018 I. Širochmanová +5 more
openalex +1 more source
Nanobodies – effektive Immunwaffen gegen Krebs
BIOspektrumAbstract Recently, we attached a nanobody targeting the cancer-relevant protein Survivin to ultrasmall gold nanoparticles. This enabled intracellular uptake, Survivin crosslinking, and interference with cancer cell mitosis. Coupling nanobodies to nanosized scaffolds is universally applicable to improve the function and therapeutic potential ...
Knauer, Shirley, Blüggel, Mike
openaire +1 more source
VIEW, EarlyView.Immunotherapy leverages the immune system to treat cancer and autoimmune diseases but is hindered by cellular heterogeneity in tissues and immune landscapes. Single‐cell technologies, particularly microfluidic‐enabled omics, revolutionize disease understanding by resolving this complexity at unprecedented resolution.
Haopu Wang, Kangfu Chen, Zongjie Wang
wiley +1 more source