Results 61 to 70 of about 19,829 (313)
Nature Communications, 2023 Chemically induced proximity (CIP) is a powerful tool to study cellular functions. However with current CIP inducers it is difficult to directly modulate unligandable and endogenous targets, and therapeutic translational potential is also restricted ...
Xiaofeng Sun +3 more
semanticscholar +1 more source
Penetration of Nanobody-Dextran Polymer Conjugates through Tumor Spheroids
Pharmaceutics, 2023 Here we report the generation of nanobody dextran polymer conjugates (dextraknobs) that are loaded with small molecules, i.e., fluorophores or photosensitizers, for potential applications in cancer diagnostics and therapy.
Peter Bitsch +6 more
doaj +1 more source
Frontiers in Immunology, 2023 Human epithelial growth factor receptor-2 (HER2) plays an oncogenic role in numerous tumors, including breast, gastric, and various other solid tumors. While anti-HER2 therapies are approved for the treatment of HER2-positive tumors, a necessity persists
Xin-long Liu +10 more
semanticscholar +1 more source
Neutralization of Human Interleukin 23 by Multivalent Nanobodies Explained by the Structure of Cytokine–Nanobody Complex [PDF]
Frontiers in Immunology, 2017 The heterodimeric cytokine interleukin (IL) 23 comprises the IL12-shared p40 subunit and an IL23-specific subunit, p19. Together with IL12 and IL27, IL23 sits at the apex of the regulatory mechanisms shaping adaptive immune responses. IL23, together with IL17, plays an important role in the development of chronic inflammation and autoimmune ...
Aline Desmyter +9 more
openalex +9 more sources
Defining molecular glues with a dual-nanobody cannabidiol sensor
Nature Communications, 2022 “Molecular glue” (MG) is a term coined to describe the mechanism of action of the plant hormone auxin and subsequently used to characterize synthetic small molecule protein degraders exemplified by immune-modulatory imide drugs (IMiDs).
Shiyun Cao +5 more
semanticscholar +1 more source
Selecting Nanobodies Specific for the Epidermal Growth Factor from a Synthetic Nanobody Library
Molecules, 2023 The epidermal growth factor (EGF) is one of the most critical ligands of the EGF receptor (EGFR), a well-known oncogene frequently overexpressed in cancerous cells and an important therapeutic target in cancer. The EGF is the target of a therapeutic vaccine aimed at inducing an anti-EGF antibody response to sequester this molecule from serum.
Yunier Serrano-Rivero +6 more
openaire +3 more sources
Nanobody-Based Sandwich Immunoassay for Pathogenic Escherichia coli F17 Strain Detection
Biosensors, 2023 Rapid and specific detection of pathogenic bacteria in fecal samples is of critical importance for the diagnosis of neonatal diarrhea in veterinary clinics.
Asma Dhehibi +7 more
semanticscholar +1 more source
Nanobody-Displaying Flagellar Nanotubes [PDF]
Scientific Reports, 2018 AbstractIn this work we addressed the problem how to fabricate self-assembling tubular nanostructures displaying target recognition functionalities. Bacterial flagellar filaments, composed of thousands of flagellin subunits, were used as scaffolds to display single-domain antibodies (nanobodies) on their surface.
Ferenc Vonderviszt +7 more
openaire +3 more sources
Evolution of nanobodies specific for BCL11A
Proceedings of the National Academy of Sciences, 2023 Transcription factors (TFs) control numerous genes that are directly relevant to many human disorders. However, developing specific reagents targeting TFs within intact cells is challenging due to the presence of highly disordered regions within these proteins.
Maolu Yin +8 more
openaire +2 more sources
Molecular Oncology, 2022 Alteration in glycosylation pattern of MUC1 mucin tandem repeats during carcinomas has been shown to negatively affect adhesive properties of malignant cells and enhance tumor invasiveness and metastasis.
Parnaz Merikhian +12 more
doaj +1 more source